Cytomorphological features of an aggressive variant of polymorphous low-grade adenocarcinoma in adolescence with lymph node metastasis

2011 ◽  
Vol 41 (2) ◽  
pp. 186-188 ◽  
Author(s):  
Sandeep Kumar Arora ◽  
Sreejesh Sreedharanunni ◽  
Pranab Dey
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Low Grade ◽  
Node Metastasis ◽  
Aggressive Variant

scholarly journals Case Report: Rare Pulmonary Sclerosing Pneumocytoma: Large, Multiple, Metastatic, and Fatal

2021 ◽  
Vol 8 ◽  
Author(s):  
Weidong Zhang ◽  
Yuanyuan Liu ◽  
Yamei Chai ◽  
Kefeng Shi ◽  
Jialing Chen ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Malignant Tumor ◽  
Abdominal Cavity ◽  
Low Grade ◽  
Node Metastasis ◽  
Multiple Lesions ◽  
Extra Pulmonary ◽  
First Time

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign or low-grade malignant tumor, but it has the potential to present with multiple lesions, lymph node metastasis, extra-pulmonary metastasis, recurrence and even cause death. Herein, a case of PSP that was huge, presented with multiple lesions and had lymph node as well as extrapulmonary metastases (liver, abdominal cavity, bones) is reported for the first time. This patient was also the first one to die of respiratory and circulatory failure caused by the PSP tumor and its metastases which compressed the mediastinal tissue.

Incidence and Pattern of Spread of Lymph Node Metastasis in Patients With Low-grade Serous Ovarian Cancer

2019 ◽  
Vol 39 (10) ◽  
pp. 5617-5621 ◽  
Author(s):  
MOHAMED WAFA ◽  
ELENA I. BRAICU ◽  
MUSTAFA Z. MUALLEM ◽  
ROLF RICHTER ◽  
ELIANE TAUBE ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Low Grade ◽  
Serous Ovarian Cancer ◽  
Node Metastasis

Application Value of Combined Detection of Serum IGF-I and IGFBP-3 in the Diagnosis of Bladder Cancer

2021 ◽  
Vol 7 (5) ◽  
pp. 3942-3947
Author(s):  
Xu-Dong Li ◽  
Sen Wei ◽  
Lei Wang
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Low Grade ◽  
Node Metastasis ◽  
Igf I ◽  
Group A ◽  
Muscle Invasive ◽  
Group B ◽  
Combined Detection ◽  
Igfbp 3

Objective. To investigate the application value of the combined detection of serum IGF-I and IGFBP-3 in the diagnosis of bladder cancer (BC). Methods.Sixty BC patients in our hospital (January 2019-January 2020) were chosen as group A, while sixty healthy people during the same period were chosen as group B. The serum IGF-I and IGFBP-3 levels of the subjects were detected to explore the relationship between the two levels (serum IGF-I and IGFBP-3) and BC.Results.Compared with group B, the two levelsof group A were lower while IGF-l/IGFBP-3 was higher. Compared with low-grade BC group, non-muscle invasive BC (NMIBC) group and non-lymph node metastasis group, the two levels were lower in high-grade BC group, muscle-invasive BC (MIBC) group and lymph node metastasis group (P<0.05). No notable difference in IGF-l/IGFBP-3 was found among patients with high-grade or low-grade BC, with or without lymph node metastasis, andwith or without muscular invasion (P>0.05). Conclusion. The serum IGF-I and IGFBP-3 levels of BC patients are obviously different compared with healthy people, and vary in patients with different types of BC, indicating the two factors can be applied in clinical diagnosic of BC.

scholarly journals A Rare Distant Metastasis of Papillary Cystadenocarcinoma Arising from Maxillary Gingiva

2020 ◽  
Vol 13 (2) ◽  
pp. 683-688
Author(s):  
Fumihiro Nishimaki ◽  
Takahiko Gibo ◽  
Keita Tsukada ◽  
Takuro Noguchi ◽  
Toshirou Fukushima ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Pulmonary Metastasis ◽  
Distant Metastasis ◽  
Regional Lymph Node ◽  
Metastatic Lesion ◽  
Careful Examination ◽  
Low Grade ◽  
Node Metastasis ◽  
Long Term Follow Up

Papillary cystadenocarcinoma is an uncommon disease with low-grade histological and clinical features. Although the tumor has the potential to produce regional lymph node metastasis, there have been no reports of cases with distant metastasis. We describe a case of papillary cystadenocarcinoma arising from the maxilla that developed pulmonary metastasis 3 years after radical surgery of the primary tumor and regional lymph node. The histological findings were confirmed on resected specimens of the pulmonary nodule and a pathological diagnosis of a metastatic lesion derived from papillary cystadenocarcinoma was made. To our knowledge, this is the first report of the development of pulmonary metastasis in a patient with papillary cystadenocarcinoma. The present case suggests that papillary cystadenocarcinoma has the potential to produce lung metastasis in the clinical course. Based on our experience, we emphasize that long-term follow-up and/or careful examination are necessary in patients with cystadenocarcinoma, especially in patients with lymph node metastasis during the initial surgical therapy.

scholarly journals 463 LVSI and Ki67 in prediction of lymph-node metastasis in primary low-grade ovarian cancer

2020 ◽  
Author(s):  
J Grabowski ◽  
J Glajzer ◽  
R Richter ◽  
H Plett ◽  
MZ Muallem ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Low Grade ◽  
Node Metastasis

scholarly journals The Dominant Somatostatin Receptor in Neuroendocrine Tumors of North Indian Population

2015 ◽  
Vol 7 (3) ◽  
pp. 60-64
Author(s):  
Narendra Krishnani ◽  
Rajneesh K Singh ◽  
Pooja Shukla
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumors ◽  
Negative Correlation ◽  
Indian Population ◽  
Somatostatin Receptor ◽  
Significant Negative Correlation ◽  
Low Grade ◽  
North Indian Population ◽  
Node Metastasis

ABSTRACT Introduction Neuroendocrine tumors (NET) express different types of somatostatin receptors (SSTRs) that bind to synthetic analogs with variable affinity. It is important to know the expression profile of SSTRs to predict biological effect of somatostatin analogues. We studied SSTR2 and SSTR5 expression by immunohistochemistry (IHC) to assess the dominant subtype in NETs and correlate the expression with histological prognostic parameters. Materials and methods Fifty-three consecutive cases of NET from all sites were evaluated for SSTR2 and SSTR5 expression by IHC. The expression was correlated with histological features of NETs. Results Forty-four cases were resected specimens and 9 were small biopsies. Nine of 53 cases (16.9%) were functional tumors. There were 24 NETs from gastrointestinal tract (GIT), 19 from pancreas and 10 from miscellaneous sites. Overall SSTR expression was seen in 43 NETs (79.2%). Somatostatin receptor 2 was expressed in 30 cases (56.6%) and SSTR5 in 39 cases (73.6%). Somatostatin receptor 2 expression showed near significant negative correlation with tumor grade and lymph node metastasis (p = 0.05). Somatostatin receptor 5 expression showed significant negative correlation with lymph node metastasis (p = 0.008) and tumor size (p = 0.02). Anatomic location and tumor necrosis were not significantly different. Somatostatin receptor 5 was dominant subtype expressed in all NETs with intense expression. Conclusion Somatostatin receptor 5 expression was the dominant subtype and expressed in small sized tumors. Somatostatin receptor 2 was expressed more in low grade NETs. Somatostatin analogs can be effective both in functional and nonfunctional NETs and can be useful in both resectable and nonresectable or metastatic tumors. How to cite this article Krishnani N, Kumari N, Singh RK, Shukla P. The Dominant Somatostatin Receptor in Neuroendocrine Tumors of North Indian Population. World J Endoc Surg 2015;7(3):60-64.

scholarly journals Solid-pseudopapillary Neoplasm of the Pancreas: A 63-Case Analysis of Clinicopathologic and Immunohistochemical Features and Risk Factors of Malignancy

2021 ◽  
Author(s):  
Hongchun Chen ◽  
Yuchen Huang ◽  
Ningning Yang ◽  
Ruxue Yang ◽  
Wentian Yan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Clinical Symptoms ◽  
Biological Behavior ◽  
Proliferation Index ◽  
Low Grade ◽  
Imaging Features ◽  
Node Metastasis

Abstract Background:Asolid-pseudopapillary neoplasm (SPN) of the pancreas, a rare tumor, has low malignant potential. However, some patients develop metastasis and recurrence after resection, with aggressive biological behaviors of SPNs. This study aimedtoexplorethefeatures andriskfactors associated withtheaggressivebiological behaviorsofSPNs.Materials and Methods: We retrospectively analyzed the clinicopathological and long-term follow-up data of 63 patients with SPN diagnosed at the First Affiliated Hospital of Bengbu Medical College between January 2007 and February 2019.Results: The 63 patients presented with atypical clinical symptoms. The mean tumor size was 7.2 cm (range, 2.4–17 cm), and imaging features were solid and cystic or solid tumors with uneven density. Frequent and diffuse nuclear LEF1 expression (94.2%) was observed with LEF1 having a higher sensitivity and specificity. Overall survival significantly correlated with tumor size, Ki-67 index, and lymph node metastasis(P<0.05).Conclusions: SPN is a rare low-grade malignancy with a specific pseudopapillary structure. LEF1 is an effective biomarker of SPNs. Although SPNs generally display indolent biological behavior, a large tumor size, high proliferation index and lymph node metastasis may be risk factors for the aggressive behavior and poor prognosis of anSPN.

scholarly journals Plasma exosome-derived fragile-site associated tumor suppressor is a powerful predictor of prognosis in patients with ovarian cancer

2021 ◽  
Author(s):  
Renjing Ju ◽  
Xiaochun Chen ◽  
Shiliang Zhang ◽  
Bin Liu ◽  
Hao Pei ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Suppressor ◽  
Fragile Site ◽  
Predictive Ability ◽  
Ca 125 ◽  
Low Grade ◽  
Node Metastasis ◽  
Close Relationship

Objective: To investigate the levels of plasma exosome-derived fragile-site associated tumor suppressor (FATS) and evaluate its predictive ability in ovarian cancer (OC) patients. Patients and Methods: Exosome-rich fractions were isolated from the plasma of enrolled 90 patients with OC. The levels of plasma exosome-derived FATS were detected with ELISA. Results: The levels of exosome-derived FATS in OC patient were significantly lower than in healthy controls (P < 0.001). The levels of plasma exosome-derived FATS were obviously higher in OC patients with low grade (1/2), FIGO stages I/II than high grade (3/4), stages III/ IV disease (P = 0.003; P < 0.001). The levels of plasma exosome-derived FATS were significantly higher in OC patients with no lymph node metastasis, no ascites than those with lymph node metastasis, ascites (both P < 0.001). The levels of plasma exosome-derived FATS were obviously higher in OC patients with CA-125 less than 35U/ml than more than 35U/ml (P < 0.001). Among all enrolled OC patients, both 5-DFS and 5-OS were shorter in patients who had low plasma exosome-derived FATS levels than that high levels (both P < 0.001). The AUROC of plasma exosome-derived FATS were 0.85(95% CI: 0.76-0.91) for 5-DFS, 0.91(95% CI: 0.83-0.96) for 5-OS prediction in patients with OC, respectively. Conclusions: Plasma exosome-derived FATS levels in OC patient were significantly down-regulated. Low levels of plasma exosome-derived FATS had close relationship with FIGO stages I/II, low grade, ascites, higher levels of CA-125, lymph node metastasis and prognosis of OC patients. Our findings may provide a new strategy in treating OC.

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