The cell with a thousand faces: Detection of myoepithelial cells and their contributions in the cytological diagnosis of salivary gland tumors

2010 ◽  
Vol 40 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Arzu Avcı ◽  
Ömer Günhan ◽  
Fulya Çakalaǧaoǧglu ◽  
Armagan Günal ◽  
Bülent Celasun
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Cytological Diagnosis

scholarly journals Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

2007 ◽  
Vol 18 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Roberta Barroso Cavalcante ◽  
Fernanda Ferreira Lopes ◽  
Andréa Soares Ferreira ◽  
Roseana de Almeida Freitas ◽  
Lélia Batista de Souza
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Low Grade ◽  
Tubular Structures ◽  
Immunohistochemical Markers ◽  
Adenoid Cystic ◽  
Peripheral Cells ◽  
Diffuse Distribution ◽  
Labeling Pattern

Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.

scholarly journals Role of myoepithelial cells in the development of salivary gland tumors

Cancer ◽  
1971 ◽  
Vol 27 (5) ◽  
pp. 1255-1261 ◽  
Author(s):  
G. Hübner ◽  
H. J. Klein ◽  
O. Kleinsasser ◽  
H. G. Schiefer
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors

Myoepithelioma

1985 ◽  
Vol 94 (5) ◽  
pp. 523-524 ◽  
Author(s):  
John G. Batsakis
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Lesion ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Mixed Tumor ◽  
Rare Form

Myoepithelial cells are integral components of normal salivary glands. Their active or passive participation in the histogenesis of several salivary gland tumors is a debated issue. This debate notwithstanding, a rare form of salivary tumor composed entirely of myoepithelial cells exists and probably represents a monomorphic form of mixed tumor. This tumor, the myoepithelioma occurs in most major and minor salivary tissues and is generally a biologically benign lesion.

Comparison of p63/p40 Expression With Myoepithelial Markers in Minor Salivary Gland Tumors

2018 ◽  
Vol 27 (4) ◽  
pp. 360-371 ◽  
Author(s):  
Lucas Novaes Teixeira ◽  
Évelin Caroline Janner ◽  
Thaís Teixeira ◽  
Fabrício Passador-Santos ◽  
Elizabeth Ferreira Martinez ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Smooth Muscle Actin ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Formalin Fixed Paraffin ◽  
Minor Salivary Gland Tumors ◽  
Formalin Fixed Paraffin Embedded ◽  
Epithelial Myoepithelial Carcinoma

The present study aimed to compare the expression of p63/p40 with smooth muscle actin (SMA) and vimentin (VIM) by myoepithelial cells in minor salivary gland tumors. Fifty-two formalin-fixed paraffin-embedded samples of minor salivary gland tumors derived from intercalated duct (pleomorphic adenoma [PA], adenoid cystic carcinoma [ACC], epithelial-myoepithelial carcinoma [EMC], polymorphous adenocarcinoma [PAC], and secretory carcinoma [SC]) and 3 samples of minor salivary gland tumors derived from excretory duct (mucoepidermoid carcinoma [MEC]) were evaluated by means of immunohistochemistry. The data were analyzed qualitatively. The results indicated that p63 and p40 expression were detected in myoepithelial cells present in PA, ACC, and EMC. However, both proteins were also observed in squamous areas of PA and all cases of MEC. SMA were noticed in some myoepithelial cells of PA, ACC, and EMC. Expression of SMA was negative in the other salivary gland tumors evaluated. VIM was constantly expressed by myoepithelial cells in PA, ACC, and EMC. VIM was also observed in cells of PAC and SC, but not in squamous areas of PA and MEC. In conclusion, p63 expression is almost comparable with VIM in detecting myoepithelial cells, an immunolabeling pattern not followed by p40, and consequently, caution has to be taken during the interpretation of salivary gland tumor exhibiting an p63/p40 phenotype in order to avoid a misdiagnosis.

scholarly journals p63 Is Expressed in Basal and Myoepithelial Cells of Human Normal and Tumor Salivary Gland Tissues

2003 ◽  
Vol 51 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Hadi Bilal ◽  
Adriana Handra-Luca ◽  
Jacques-Charles Bertrand ◽  
Pierre J. Fouret
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors ◽  
Basal Cells ◽  
Squamous Cells ◽  
Human Salivary Gland ◽  
Duct Cells ◽  
Normal Human ◽  
Luminal Cells ◽  
Tumor Types

p63 is essential for epithelial cell survival and may function as an oncogene. We examined by immunohistochemistry p63 expression in human normal and tumor salivary gland tissues. In normal salivary glands, p63 was expressed in the nuclei of myoepithelial and basal duct cells. Among 68 representative salivary gland tumors, 63 displayed p63 reactivity. In all tumor types differentiated towards luminal and myoepithelial lineages (pleomorphic adenomas, basal cell adenomas, adenoid cystic carcinomas, and epithelial-myoepithelial carcinomas), p63 was expressed in myoepithelial cells, whereas luminal cells were always negative. Similarly, in mucoepidermoid carcinomas, basal, intermediate, and squamous cells expressed p63, in contrast to luminal mucous cells. p63 reactivity was also restricted to basal cells in Warthin tumors and oncocytomas. Myoepitheliomas and myoepithelial carcinomas all expressed p63. The only five negative tumors were three of four acinar cell carcinomas and two of three adenocarcinomas. In conclusion, p63 is expressed in the nuclei of normal human salivary gland myoepithelial and basal duct cells. p63 expression is retained in the modified myoepithelial and basal cells of human salivary gland tumors, which suggests a role for p63 in oncogenesis of these complex tumors.

Actin versus vimentin in myoepithelial cells of salivary gland tumors

1994 ◽  
Vol 77 (4) ◽  
pp. 387-391 ◽  
Author(s):  
Vera Cavalcanti de Araujo ◽  
Yasmin Rodarte Carvalho ◽  
Ney Soares de Araujo
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors

Myoepithelial cells: Current perspectives in salivary gland tumors

2013 ◽  
Vol 2 (2) ◽  
pp. 101 ◽  
Author(s):  
VSuresh Kandagal ◽  
Nupura Vibhute ◽  
SharanJ Shetty ◽  
Sameer Ahamad ◽  
PramodS Ingaleshwar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Myoepithelial Cells ◽  
Salivary Gland Tumors

MULTI-MODALITY IMAGING OF SALIVARY GLAND TUMORS

2021 ◽  
pp. 39-41
Author(s):  
Yashvant Singh ◽  
Namrita Sachdev ◽  
Akhila Prasad ◽  
Rushil Jain ◽  
Dinesh Sethi
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Cell Cancer ◽  
Myoepithelial Cells ◽  
The Body ◽  
Salivary Gland Tumors ◽  
Upper Aerodigestive Tract ◽  
Cross Sectional ◽  
Cross Sectional Imaging

Background: Imaging of salivary gland tumors is a challenge for the radiologist due to varied histological features and overlapping clinical presentation.The salivary glands have a glandular structure with tubules, secretory acini and myoepithelial cells to produce and secrete saliva. They are divided into two types: major and minor. Parotid, submandibular, and sublingual glands are the major paired salivary glands of the body. Multiple small minor salivary glands are distributed in the upper aerodigestive tract including PNS & parapharyngeal spaces. Objective: This study evaluates the role of different modalities used to assess salivary gland tumors. Results: 50 patients presenting with suspected salivary gland masses were evaluated. 22 males and 28 females were assessed with age ranging from 15 to 66 years (mean age of 52 years). 27 cases were of pleomorphic adenoma, 10 warthin tumors, 2 intraductal papilloma,1 lipoma, 1 oncocytoma,1 intra parotid paraganglioma, 2 hemangioma, 3 muco-epidermoid carcinoma, 2 adeno cystic cancer and 1 acinic cell cancer of salivary gland. 90% of patients (45 out of 50) presented with swelling / lump. 26% of patients had pain /discomfort and 4% of patients (2 out of 50) had facial nerve palsy. Conclusion: The conventional radiological evaluation was carried out using Xray and ultrasound with USG as rst line of investigation.. Cross sectional imaging with CT and MRI is useful in assessing for local extension , invasion of neighbouring structures as well as lymph nodal and systemic metastasis.MRI is superior to CT in assesing for extent and perineural spread.

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