Clinical relevance of benign endometrial cells in postmenopausal women

2001 ◽  
Vol 25 (4) ◽  
pp. 235-238 ◽  
Author(s):  
Raheela Ashfaq ◽  
Suash Sharma ◽  
Tara Dulley ◽  
M. Hossein Saboorian ◽  
Momin T. Siddiqui ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Clinical Relevance ◽  
Endometrial Cells

Significance of Cytologically Normal Endometrial Cells in Cervical Smears from Postmenopausal Women

2001 ◽  
Vol 45 (2) ◽  
pp. 153-156 ◽  
Author(s):  
Venetia R. Sarode ◽  
Anne E. Rader ◽  
Peter G. Rose ◽  
Michael Rodriguez ◽  
Fadi W. Abdul-Karim
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Cells ◽  
Cervical Smears

Cytologically Benign Endometrial Cells in the Papanicolaou Smears of Postmenopausal Women

2001 ◽  
Vol 80 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Andrea Chang ◽  
Lynn Sandweiss ◽  
Shikha Bose
Keyword(s):  
Postmenopausal Women ◽  
Endometrial Cells ◽  
Papanicolaou Smears

Normal appearing endometrial cells in cervical smears of asymptomatic postmenopausal women have predictive value for significant endometrial pathology

2006 ◽  
Vol 16 (3) ◽  
pp. 1069-1074 ◽  
Author(s):  
A. G. Siebers ◽  
A. L.M. Verbeek ◽  
L. F. Massuger ◽  
J. M.M. Grefte ◽  
J. Bulten
Keyword(s):  
Postmenopausal Women ◽  
Uterine Disease ◽  
Abnormal Finding ◽  
Endometrial Cells ◽  
Gynecological Examination ◽  
Hormone Use ◽  
Maturation Index ◽  
Asymptomatic Women ◽  
Endometrial Pathology

The objective of this study was to determine whether postmenopausal asymptomatic women with normal endometrial cells in their smear are at higher risk for endometrial pathology compared with women without these cells. Histologic follow-up outcome and otherwise cytologic follow-up of 29,144 asymptomatic postmenopausal women was determined. Presence of normal endometrial cells, age, use of hormones, and reported elevated maturation index were assessed. The effect of each variable on outcome as well as the combined effect were evaluated. Prevalence rate of (pre)malignant uterine disease was significantly higher when normal endometrial cells were found in the cervical smear (6.5%) as compared to smears without these cells (0.2%), resulting in a relative risk of 40.2 (95% CI 9.4–172.2). Neither age nor hormone use or elevated maturation index showed significant impact on the outcome. Asymptomatic postmenopausal women with normal endometrial cells in their smear are at significant higher risk for (pre)cancerous endometrial lesion than women without these cells. These cases should be reported to the physician with an explicit comment that normal endometrial cells in a smear of a postmenopausal woman is an abnormal finding, possibly associated with significant endometrial pathology. It raises the question whether further gynecological examination would be more appropriate.

Normal endometrial cells in cervical cytology: systematic review of prevalence and relation to significant endometrial pathology

2008 ◽  
Vol 15 (4) ◽  
pp. 188-198 ◽  
Author(s):  
Karen Canfell ◽  
Yoon Jung Kang ◽  
Mark Clements ◽  
Aye Myat Moa ◽  
Valerie Beral
Keyword(s):  
Systematic Review ◽  
Postmenopausal Women ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Abnormal Uterine Bleeding ◽  
Summary Estimate ◽  
Endometrial Cells ◽  
Endocervical Canal ◽  
Changes Over Time ◽  
Endometrial Pathology

Objectives To estimate the prevalence of normal endometrial cells (NECs) and the proportion of NECs associated with significant endometrial pathology in conventional and liquid-based cytology (LBC) cervical smears; and to assess the association between NECs and clinical symptoms in women with endometrial hyperplasia or carcinoma. Methods Systematic review of the literature and meta-analysis of prevalence and proportion data. The review was confined to studies reporting on NECs in smears from postmenopausal women or women aged 40+. Results A total of 22 relevant primary studies were identified from 1970 to 2007. The overall summary estimate for the prevalence of NECs in smears from postmenopausal women or women aged 40+ in all screening smears was 0.4% (95% CI 0.2–0.7%); this was 0.3% (95% CI 0.1–0.5%) and 0.9% (95% CI 0.5–1.4%) for conventional and LBC smears, respectively; P = 0.003 for difference. The overall estimate for the proportion of NECs associated with significant endometrial pathology was 7% (95% CI 4–10%); this was 11% (95% CI 8–14%) and 2% (95% CI 1–2%) for conventional and LBC smears, respectively; P < 0.001 for difference. In women with significant endometrial pathology, the presence of NECs in followed-up women was associated with abnormal uterine bleeding in 79% (95% CI 68–87%) of cases. Conclusion Compared with conventional cytology, LBC may be associated with a higher prevalence of NECs but these are less likely to be associated with endometrial pathology. This finding might be explained by more consistent use of sampling instruments for LBC with better access to the endocervical canal or alternatively by changes over time, broadly coincident with the introduction of LBC, in the population in which NECs are reported. In followed-up women with NECs, most endometrial pathology is accompanied by symptoms, implying that a relatively smaller number of additional cases are identified through follow-up of asymptomatic women.

Frequency of Adequate Endometrial Biopsy in Evaluation of Postmenopausal Women With Benign Endometrial Cells on Pap Test

2017 ◽  
Vol 21 (4) ◽  
pp. 258-260 ◽  
Author(s):  
Jeffrey W. Hastings ◽  
Meredith J. Alston ◽  
Sara E. Mazzoni ◽  
Elaine Stickrath
Keyword(s):  
Postmenopausal Women ◽  
Pap Test ◽  
Endometrial Biopsy ◽  
Endometrial Cells
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