Acinic-cell carcinoma, papillary-cystic variant: A diagnostic dilemma in salivary gland aspiration

2002 ◽  
Vol 27 (4) ◽  
pp. 244-250 ◽  
Author(s):  
Syed Z. Ali
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Diagnostic Dilemma ◽  
Acinic Cell

scholarly journals ACINIC CELL CARCINOMA OF PAROTID GLAND – A CASE REPORT

2020 ◽  
pp. 66-67
Author(s):  
J. Priyadharisini ◽  
Partho Protim Barman ◽  
U. Bharathi
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Diagnostic Dilemma ◽  
Gold Standard Method ◽  
Acinic Cell

Acinic cell carcinoma (ACC) is a rare type of tumor which accounts for only 1–3% of the salivary gland tumors. Majority of which occurs in the parotid gland. ACC can be misinterpreted as benign because of its low grade histology. Radiological imaging techniques have low sensitivity in detecting malignancy of parotid glands. Guided FNAC can prove to be reliable diagnostic modality that can help in differential diagnosis of salivary gland neoplasms. Aspirates from these tumors can be diagnostically challenging. The lesions that have to be considered in the differential diagnosis include a wide variety of nonneoplastic as well as neoplastic conditions and pose a serious diagnostic dilemma cytologically. Hence histopathological examination is the gold standard method of choice for diagnosing these tumors. Here we report a case of Acinic cell carcinoma of parotid gland which had cytological diagnostic dilemma and confirmed diagnosis following histopathology examination.

scholarly journals A Case Report and Genetic Characterization of a Massive Acinic Cell Carcinoma of the Parotid with Delayed Distant Metastases

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Anthony C. Nichols ◽  
Michelle Chan-Seng-Yue ◽  
John Yoo ◽  
Sumit K. Agrawal ◽  
Maud H. W. Starmans ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Large Scale ◽  
Cellular Proliferation ◽  
Genetic Characterization ◽  
Distant Metastases ◽  
Acinic Cell Carcinoma ◽  
Nonsynonymous Mutation ◽  
Acinic Cell

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure.

scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland

2020 ◽  
Author(s):  
Yuichiro Hamamoto ◽  
Hiroshi Harada ◽  
Masaharu Kohara ◽  
Keiichiro Honma ◽  
Shin-ichi Nakatsuka ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Secretory Carcinoma ◽  
Acinic Cell
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