Relationship between the hippocampal shape abnormality and serum cortisol levels in first-episode and drug-naïve major depressive disorder patients

2017 ◽  
Vol 34 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Rieko Watanabe ◽  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Xiaodan Liu ◽  
Asuka Katsuki ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serum Cortisol ◽  
First Episode ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels

scholarly journals Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
LeHoa Nguyen ◽  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Asuka Katsuki ◽  
Koichiro Sugimoto ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serum Cortisol ◽  
Brain Morphology ◽  
Morphometric Study ◽  
First Episode ◽  
Major Depressive ◽  
Neuropsychiatric Diseases ◽  
Drug Naïve ◽  
Cortisol Levels

AbstractHigher cortisol levels due to a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). Increased cortisol levels change both the brain morphology and function in MDD patients. The multivariate source-based morphometry (SBM) technique has been applied to investigate neuroanatomical changes in some neuropsychiatric diseases, but not MDD. We aimed to examine the alterations in gray matter (GM) networks and their relationship with serum cortisol levels in first-episode, drug-naïve MDD patients using SBM. Forty-two patients with MDD and 39 controls were recruited via interviews. Morning serum cortisol levels were measured, and high-resolution T1-weighted imaging followed by SBM analysis was performed in all participants. The patients had significantly higher serum cortisol levels than the controls. We found two GM sources, which were significantly different between patients with MDD and controls (prefrontal network, p < .01; insula-temporal network, p < .01). Serum cortisol levels showed a statistically significant negative correlation with the loading coefficients of the prefrontal network (r = − 0.354, p = 0.02). In conclusion, increased serum cortisol levels were associated with reductions in the prefrontal network in the early stage of MDD, and SBM may be a useful approach for analyzing structural MRI data.

scholarly journals Relationship between white matter integrity and serum cortisol levels in drug-naive patients with major depressive disorder: Diffusion tensor imaging study using tract-based spatial statistics

2016 ◽  
Vol 208 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Xiaodan Liu ◽  
Keita Watanabe ◽  
Shingo Kakeda ◽  
Reiji Yoshimura ◽  
Osamu Abe ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Diffusion Tensor ◽  
Serum Cortisol ◽  
White Matter Integrity ◽  
Uncinate Fasciculus ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels ◽  
Anterior Thalamic Radiation

BackgroundHigher daytime cortisol levels because of a hyperactive hypothalamic–pituitary–adrenal axis have been reported in patients with major depressive disorder (MDD). The elevated glucocorticoids inhibit the proliferation of the oligodendrocytes that are responsible for myelinating the axons of white matter fibre tracts.AimsTo evaluate the relationship between white matter integrity and serum cortisol levels during a first depressive episode in drug-naive patients with MDD (MDD group) using a tract-based spatial statistics (TBSS) method.MethodThe MDD group (n = 29) and a healthy control group (n = 47) underwent diffusion tensor imaging (DTI) scans and an analysis was conducted using TBSS. Morning blood samples were obtained from both groups for cortisol measurement.ResultsCompared with the controls, the MDD group had significantly reduced fractional anisotropy values (P<0.05, family-wise error (FWE)-corrected) in the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation. The fractional anisotropy values of the inferior fronto-occipital fasciculus, uncinate fasciculus and anterior thalamic radiation had significantly negative correlations with the serum cortisol levels in the MDD group (P<0.05, FWE-corrected).ConclusionsOur findings indicate that the elevated cortisol levels in the MDD group may injure the white matter integrity in the frontal–subcortical and frontal–limbic circuits.

Psychotic symptoms in first‐episode and drug naïve patients with major depressive disorder: Prevalence and related clinical factors

2020 ◽  
Vol 37 (8) ◽  
pp. 793-800
Author(s):  
Yanmei Shen ◽  
Ying Wei ◽  
Xu‐Na Yang ◽  
Guangya Zhang ◽  
Xiangdong Du ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Clinical Factors ◽  
Major Depressive ◽  
Drug Naïve
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