scholarly journals Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial

2017 ◽  
Vol 34 (6) ◽  
pp. 508-517 ◽  
Author(s):  
Joaquin A. Anguera ◽  
Faith M. Gunning ◽  
Patricia A. Areán
Keyword(s):  
Cognitive Control ◽  
Randomized Trial ◽  
Video Game ◽  
Late Life ◽  
Proof Of Concept ◽  
Late Life Depression ◽  
Video Game Technology

scholarly journals Cognitive Control in Late-Life Depression: Response Inhibition Deficits and Dysfunction of the Anterior Cingulate Cortex

2010 ◽  
Vol 18 (11) ◽  
pp. 1017-1025 ◽  
Author(s):  
Richard Katz ◽  
Pierfilippo De Sanctis ◽  
Jeannette R. Mahoney ◽  
Pejman Sehatpour ◽  
Christopher F. Murphy ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Anterior Cingulate Cortex ◽  
Response Inhibition ◽  
Late Life ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Late Life Depression

scholarly journals Functional connectivity in the cognitive control network and the default mode network in late-life depression

2012 ◽  
Vol 139 (1) ◽  
pp. 56-65 ◽  
Author(s):  
George S. Alexopoulos ◽  
Matthew J. Hoptman ◽  
Dora Kanellopoulos ◽  
Christopher F. Murphy ◽  
Kelvin O. Lim ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Cognitive Control ◽  
Default Mode Network ◽  
Late Life ◽  
Control Network ◽  
Late Life Depression ◽  
Default Mode ◽  
Cognitive Control Network

scholarly journals Cognitive control, reward-related decision making and outcomes of late-life depression treated with an antidepressant

2015 ◽  
Vol 45 (14) ◽  
pp. 3111-3120 ◽  
Author(s):  
G. S. Alexopoulos ◽  
K. Manning ◽  
D. Kanellopoulos ◽  
A. McGovern ◽  
J. K. Seirup ◽  
...  
Keyword(s):  
Decision Making ◽  
Cognitive Control ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Rating Scale ◽  
Late Life ◽  
Hierarchical Cluster ◽  
Late Life Depression ◽  
Patients At Risk ◽  
Poor Outcomes ◽  
Abnormal Performance

Background.Executive processes consist of at least two sets of functions: one concerned with cognitive control and the other with reward-related decision making. Abnormal performance in both sets occurs in late-life depression. This study tested the hypothesis that only abnormal performance in cognitive control tasks predicts poor outcomes of late-life depression treated with escitalopram.Method.We studied older subjects with major depression (N = 53) and non-depressed subjects (N = 30). Executive functions were tested with the Iowa Gambling Test (IGT), Stroop Color-Word Test, Tower of London (ToL), and Dementia Rating Scale – Initiation/Perseveration domain (DRS-IP). After a 2-week placebo washout, depressed subjects received escitalopram (target daily dose: 20 mg) for 12 weeks.Results.There were no significant differences between depressed and non-depressed subjects on executive function tests. Hierarchical cluster analysis of depressed subjects identified a Cognitive Control cluster (abnormal Stroop, ToL, DRS-IP), a Reward-Related cluster (IGT), and an Executively Unimpaired cluster. Decline in depression was greater in the Executively Unimpaired (t = −2.09, df = 331, p = 0.0375) and the Reward-Related (t = −2.33, df = 331, p = 0.0202) clusters than the Cognitive Control cluster. The Executively Unimpaired cluster (t = 2.17, df = 331, p = 0.03) and the Reward-Related cluster (t = 2.03, df = 331, p = 0.0433) had a higher probability of remission than the Cognitive Control cluster.Conclusions.Dysfunction of cognitive control functions, but not reward-related decision making, may influence the decline of symptoms and the probability of remission of late-life depression treated with escitalopram. If replicated, simple to administer cognitive control tests may be used to select depressed older patients at risk for poor outcomes to selective serotonin reuptake inhibitors who may require structured psychotherapy.

scholarly journals Characterizing cognitive control abilities in children with 16p11.2 deletion using adaptive ‘video game’ technology: a pilot study

2016 ◽  
Vol 6 (9) ◽  
pp. e893-e893 ◽  
Author(s):  
J A Anguera ◽  
A N Brandes-Aitken ◽  
C E Rolle ◽  
S N Skinner ◽  
S S Desai ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cognitive Control ◽  
Video Game ◽  
Adaptive Video ◽  
Video Game Technology

scholarly journals Cognitive Control Network Homogeneity and Executive Functions in Late-Life Depression

2020 ◽  
Vol 5 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Matteo Respino ◽  
Matthew J. Hoptman ◽  
Lindsay W. Victoria ◽  
George S. Alexopoulos ◽  
Nili Solomonov ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Executive Functions ◽  
Late Life ◽  
Control Network ◽  
Late Life Depression ◽  
Cognitive Control Network

Refining Evidence-Based Treatments for Late-Life Depression

GeroPsych ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 67-76
Author(s):  
Grace C. Niu ◽  
Patricia A. Arean
Keyword(s):  
Older Adults ◽  
Mental Illness ◽  
Brain Plasticity ◽  
Late Life ◽  
Aging Population ◽  
The United States ◽  
Future Research ◽  
Evidence Based ◽  
Late Life Depression ◽  
Evidence Based Treatments

The recent increase in the aging population, specifically in the United States, has raised concerns regarding treatment for mental illness among older adults. Late-life depression (LLD) is a complex condition that has become widespread among the aging population. Despite the availability of behavioral interventions and psychotherapies, few depressed older adults actually receive treatment. In this paper we review the research on refining treatments for LLD. We first identify evidence-based treatments (EBTs) for LLD and the problems associated with efficacy and dissemination, then review approaches to conceptualizing mental illness, specifically concepts related to brain plasticity and the Research Domain Criteria (RDoc). Finally, we introduce ENGAGE as a streamlined treatment for LLD and discuss implications for future research.

Sign in / Sign up

Export Citation Format

Share Document