AUGMENTATION STRATEGIES FOR TREATMENT-RESISTANT ANXIETY DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS

2016 ◽  
Vol 33 (8) ◽  
pp. 728-736 ◽  
Author(s):  
Beth Patterson ◽  
Michael Van Ameringen
Keyword(s):  
Systematic Review ◽  
Anxiety Disorders ◽  
Meta Analysis ◽  
Treatment Resistant ◽  
Augmentation Strategies

scholarly journals Systematic review and meta-analysis of randomized controlled trials of ketamine in the treatment of refractory anxiety spectrum disorders

2021 ◽  
Vol 11 ◽  
pp. 204512532110567
Author(s):  
Elizabeth Whittaker ◽  
Alisher R. Dadabayev ◽  
Sonalee A. Joshi ◽  
Paul Glue
Keyword(s):  
Systematic Review ◽  
Anxiety Disorders ◽  
Maintenance Therapy ◽  
Dose Response ◽  
Maintenance Treatment ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Treatment Resistant ◽  
Randomized Controlled ◽  
Spectrum Disorders

Background: Anxiety disorders are common, associated with significant burden of disease, and have high levels of treatment resistance. Low-dose ketamine has been extensively studied in treatment-resistant depression, with fewer reports in treatment-resistant anxiety disorders. Aims: This systematic review and meta-analysis collected efficacy, safety, and tolerability data for ketamine as a treatment for anxiety spectrum disorders. Methods: We conducted a systematic search for randomized controlled trials (RCTs) of acute ketamine treatment for patients with anxiety disorders. Open-label trials of ketamine maintenance therapy were also considered. Qualitative and, where possible, quantitative syntheses of findings were performed using Review Manager software (RevMan). Acute dose-response and maintenance treatment data were also collected. Results: There were six eligible acute RCTs – two in social anxiety disorder (SAD), three in post-traumatic stress disorder (PTSD), and one in obsessive-compulsive disorder (OCD). Four of the six showed significant improvement in anxiety rating scores in ketamine compared with control groups. Pooled analysis showed ketamine was associated with an increased likelihood of treatment response for SAD (odds ratio (OR): 28.94; 95% confidence interval [CI]: 3.45–242.57; p = 0.002) but not for PTSD (OR: 2.03; 95% CI: 0.67–6.15; p = 0.21). A dose-response profile was observed for ketamine and changes in SAD symptoms, with doses ⩾0.5 mg/kg associated with greater reduction in anxiety rating scores than lower doses. Ketamine maintenance therapy was associated with sustained anxiolytic effects and improved social and/or work functioning. Conclusion: These preliminary analyses suggest that acute ketamine may be broadly effective across treatment-resistant anxiety spectrum disorders. These effects can be prolonged with maintenance treatment. Future studies will be needed to provide critical knowledge gaps around off-label use, side effects, and potential risks for abuse in clinical settings.

scholarly journals Hatha yoga for acute, chronic and/or treatment-resistant mood and anxiety disorders: A systematic review and meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0204925 ◽  
Author(s):  
Nina K. Vollbehr ◽  
Agna A. Bartels-Velthuis ◽  
Maaike H. Nauta ◽  
Stynke Castelein ◽  
Laura A. Steenhuis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Anxiety Disorders ◽  
Meta Analysis ◽  
Hatha Yoga ◽  
Treatment Resistant ◽  
Mood And Anxiety Disorders

Augmentation Strategies For Treatment Resistant Major Depression: A Systematic Review And Network Meta-Analysis

2022 ◽  
Author(s):  
Nicolas A Nuñez ◽  
Boney Joseph ◽  
Mehak Pahwa ◽  
Rakesh Kumar ◽  
Manuel Gardea Resendez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Major Depression ◽  
Meta Analysis ◽  
Treatment Resistant ◽  
Augmentation Strategies

scholarly journals Effectiveness of Catheter-Based Renal Denervation for Treatment Resistant Hypertension – Results of a Systematic Review and Meta-Analysis

2014 ◽  
Vol 17 (7) ◽  
pp. A757-A758 ◽  
Author(s):  
M. McBride ◽  
H. Krum ◽  
M. Schlaich ◽  
R. Whitbourn ◽  
T. Walton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Resistant Hypertension ◽  
Renal Denervation ◽  
Meta Analysis ◽  
Treatment Resistant

scholarly journals Augmentation therapies for treatment-resistant depression: systematic review and meta-analysis – CORRIGENDUM

2018 ◽  
Vol 214 (5) ◽  
pp. 308-308
Author(s):  
Rebecca Strawbridge ◽  
Ben Carter ◽  
Lindsey Marwood ◽  
Borwin Bandelow ◽  
Dimosthenis Tsapekos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Resistant Depression
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