NEURAL CORRELATES OF RISKY DECISION MAKING IN ANXIOUS YOUTH AND HEALTHY CONTROLS

2014 ◽  
Vol 31 (7) ◽  
pp. 591-598 ◽  
Author(s):  
Adriana Galván ◽  
Tara S. Peris
2011 ◽  
Vol 17 (2) ◽  
pp. 465-478 ◽  
Author(s):  
Jodi M. Gilman ◽  
Ashley R. Smith ◽  
Vijay A. Ramchandani ◽  
Reza Momenan ◽  
Daniel W. Hommer

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0166995 ◽  
Author(s):  
Annemarie C. Visser-Keizer ◽  
Herma J. Westerhof-Evers ◽  
Marleen J. J. Gerritsen ◽  
Joukje van der Naalt ◽  
Jacoba M. Spikman

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Li-Lin Rao ◽  
John C. Dunn ◽  
Yuan Zhou ◽  
Shu Li

2012 ◽  
Vol 37 (2) ◽  
pp. 176-183 ◽  
Author(s):  
C.-Y. Peter Chiu ◽  
Sarah J. Tlustos ◽  
Nicolay Chertkoff Walz ◽  
Scott K. Holland ◽  
James C. Eliassen ◽  
...  

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S252-S253
Author(s):  
Mary Chung Man Ng ◽  
Joe Kwun Nam Chan ◽  
Martha Luk ◽  
Cheuk Fei Wong ◽  
Sui Fung Wo ◽  
...  

Abstract Background Previous research suggests that bipolar disorder may be associated with increased risk-taking / impulsivity. Risky decision-making paradigm is an objective, performance-based measure which has been increasingly applied in bipolar disorder research examining. Nonetheless, literature focused only on chronically ill samples, with illness chronicity, clinical heterogeneity and prolonged medication exposure being potential confounding factors of study results. The current study aimed to explore whether patients with early-stage psychotic bipolar disorder (BDP) exhibit impaired risky decision-making relative to healthy controls, using a well-validated, widely-applied experimental paradigm of Balloon Analogue Risk Task (BART). Methods Thirty-nine patients with early-stage BDP (defined by having received psychiatric treatment for first-episode BDP within 3 years since service entry) and 36 demographically matched healthy controls were recruited. BART was administered to examine risky decision-making performance. Deliberative risky behavior was operationalized as the willingness to inflate balloons as each pump was accompanied by an extra point gained in the temporary repository or balloon explosion. Three performance-based indices (adjusted score, explosion rate and cumulative score) were derived and analyzed. Results There were no significant differences between patients and controls in age, gender and educational levels. Independent samples t-tests illustrated that patients had significantly lower adjusted score (t = -3.45, p = .001, d = .791), explosion rate (t = -2.75, p = .007, d = .631) and cumulative score (t = -3.07, p = .003, d = .714) in BART compared to controls. Similar findings were obtained when comparison analyses were restricted to patients who were treated with antipsychotic medications at the time of study assessment (n = 30). No significant correlations between BART performance-based indices and measures of clinical and treatment variables were found in patient sample. Discussion Our results demonstrated that early-stage BDP patients displayed suboptimal risky decision-making compared with controls. Abnormal risky decision-making observed in the euthymic state of patients in early stage of bipolar disorder suggests that such impairment might represent a trait factor in the disorder. Further prospective research is warranted to clarify the longitudinal course of risky decision-making impairment in bipolar disorder.


2010 ◽  
Vol 23 (3) ◽  
pp. 131-143 ◽  
Author(s):  
Kirsten Labudda ◽  
Matthias Brand ◽  
Markus Mertens ◽  
Isabelle Ollech ◽  
Hans J. Markowitsch ◽  
...  

We aimed to study whether previously described impairment in decision making under risky conditions in patients with Parkinson's disease (PD) is affected by deficits in using information about potential incentives or by processing feedback (in terms of fictitious gains and losses following each decision). Additionally, we studied whether the neural correlates of using explicit information in decision making under risk differ between PD patients and healthy subjects. We investigated ten cognitively intact PD patients and twelve healthy subjects with the Game of Dice Task (GDT) to assess risky decision making, and with an fMRI paradigm to analyse the neural correlates of information integration in the deliberative decision phase. Behaviourally, PD patients showed selective impairment in the GDT but not on the fMRI task that did not include a feedback component. Healthy subjects exhibited lateral prefrontal, anterior cingulate and parietal activations when integrating decision-relevant information. Despite similar behavioural patterns on the fMRI task, patients exhibited reduced parietal activation. Behavioural results suggest that PD patients’ deficits in risky decision making are dominated by impaired feedback utilization not compensable by intact cognitive functions. Our fMRI results suggest similarities but also differences in neural correlates when using explicit information for the decision process, potentially indicating different strategy application even if the interfering feedback component is excluded.


2011 ◽  
Author(s):  
Jared Hotaling ◽  
Jerry Busemeyer ◽  
Richard Shiffrin

Sign in / Sign up

Export Citation Format

Share Document