scholarly journals INSULA AND ANTERIOR CINGULATE GABA LEVELS IN POSTTRAUMATIC STRESS DISORDER: PRELIMINARY FINDINGS USING MAGNETIC RESONANCE SPECTROSCOPY

2013 ◽  
Vol 31 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Isabelle M. Rosso ◽  
Melissa R. Weiner ◽  
David J. Crowley ◽  
Marisa M. Silveri ◽  
Scott L. Rauch ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy

scholarly journals Evidence for Acquired Pregenual Anterior Cingulate Gray Matter Loss from a Twin Study of Combat-Related Posttraumatic Stress Disorder

2008 ◽  
Vol 63 (6) ◽  
pp. 550-556 ◽  
Author(s):  
Kiyoto Kasai ◽  
Hidenori Yamasue ◽  
Mark W. Gilbertson ◽  
Martha E. Shenton ◽  
Scott L. Rauch ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Gray Matter ◽  
Twin Study ◽  
Stress Disorder ◽  
Anterior Cingulate ◽  
Gray Matter Loss

scholarly journals Impaired cognitive self-awareness mediates the association between alexithymia and excitation/inhibition balance in the pgACC

2019 ◽  
Vol 50 (10) ◽  
pp. 1727-1735
Author(s):  
A. Kühnel ◽  
A. Widmann ◽  
L. Colic ◽  
L. Herrmann ◽  
L. R. Demenescu ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Negative Feedback ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Self Awareness ◽  
Cortical Areas ◽  
Cognitive Awareness ◽  
Healthy Participants

AbstractBackgroundPrevious research showed that automatic emotion regulation is associated with activation of subcortical areas and subsequent feedforward processes to cortical areas. In contrast, cognitive awareness of emotions is mediated by negative feedback from cortical to subcortical areas. Pregenual anterior cingulate cortex (pgACC) is essential in the modulation of both affect and alexithymia. We considered the interplay between these two mechanisms in the pgACC and their relationship with alexithymia.MethodIn 68 healthy participants (30 women, age = 26.15 ± 4.22) we tested associations of emotion processing and alexithymia with excitation/inhibition (E/I) balance represented as glutamate (Glu)/GABA in the pgACC measured via magnetic resonance spectroscopy in 7 T.ResultsAlexithymia was positively correlated with the Glu/GABA ratio (N = 41, p = 0.0393). Further, cognitive self-awareness showed an association with Glu/GABA (N = 52, p = 0.003), which was driven by a correlation with GABA. In contrast, emotion regulation was only correlated with glutamate levels in the pgACC (N = 49, p = 0.008).ConclusionOur results corroborate the importance of the pgACC as a mediating region of alexithymia, reflected in an altered E/I balance. Furthermore, we could specify that this altered balance is linked to a GABA-related modulation of cognitive self-awareness of emotions.

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