Hypofrontality in panic disorder and major depressive disorder assessed by multi-channel near-infrared spectroscopy

2008 ◽  
Vol 25 (12) ◽  
pp. 1053-1059 ◽  
Author(s):  
Haruhisa Ohta ◽  
Bun Yamagata ◽  
Hiroi Tomioka ◽  
Taro Takahashi ◽  
Madoka Yano ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Infrared Spectroscopy ◽  
Panic Disorder ◽  
Depressive Disorder ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Major Depressive

Functional near-infrared spectroscopy during a decision-making task in patients with major depressive disorder

2020 ◽  
pp. 000486742097685
Author(s):  
Syeda F Husain ◽  
Samantha K Ong ◽  
Liu Cuizhen ◽  
Bach Tran ◽  
Roger C Ho ◽  
...  
Keyword(s):  
Decision Making ◽  
Major Depressive Disorder ◽  
Infrared Spectroscopy ◽  
Depressive Disorder ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Iowa Gambling Task ◽  
Major Depressive ◽  
Functional Near Infrared Spectroscopy ◽  
Decision Making Processes

Objective: Patients with major depressive disorder tend to exhibit poorer decision-making capacity than the general population, but neurobiological evidence is lacking. Functional near-infrared spectroscopy monitors changes in oxy-haemoglobin concentration in the cerebral cortex. It may provide an objective assessment of neurophysiological responses during decision-making processes. Thus, this study investigated the effect of major depressive disorder diagnosis and severity on prefrontal cortex activity during the Iowa gambling task. Methods: Right-handed healthy controls ( n = 25) and patients with major depressive disorder ( n = 25) were matched for age, gender, ethnicity and years of education in this cross-sectional study. Functional near-infrared spectroscopy signals and the responses made during a computerised Iowa gambling task were recorded. In addition, demographics, clinical history and symptom severity were noted. Results: Compared to healthy controls, patients with major depressive disorder had reduced haemodynamic response in several cortical regions of the frontal lobe (Hedge’s g range from 0.71 to 1.52; p values range from ⩽0.001 to 0.041). Among patients, mean oxy-haemoglobin declined with major depressive disorder severity in the right orbitofrontal cortex (Pearson’s r = −0.423; p = 0.024). Conclusion: Haemodynamic dysfunction of the prefrontal cortex during decision-making processes is associated with major depressive disorder diagnosis and severity. These neurophysiological alterations may have a role in the decision-making capacity of patients with major depressive disorder.

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