Morphometric alterations of anterior superior temporal cortex in obsessive–compulsive disorder

2006 ◽  
Vol 23 (5) ◽  
pp. 290-296 ◽  
Author(s):  
Jung-Seok Choi ◽  
Hye-Soo Kim ◽  
So Young Yoo ◽  
Tae-Hyun Ha ◽  
Joon-Hwan Chang ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Temporal Cortex ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Superior Temporal Cortex

Default network connectivity as a vulnerability marker for obsessive compulsive disorder

2013 ◽  
Vol 44 (7) ◽  
pp. 1475-1484 ◽  
Author(s):  
Z. W. Peng ◽  
T. Xu ◽  
Q. H. He ◽  
C. Z. Shi ◽  
Z. Wei ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Genetic Risk ◽  
Temporal Cortex ◽  
Network Connectivity ◽  
Default Network ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Potential Marker

BackgroundAberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown.MethodHere, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population.ResultsCompared with healthy controls, OCD patients exhibited reduced strength of default network functional connectivity with the posterior cingulate cortex (PCC), and increased functional connectivity in the right inferior frontal lobe, insula, superior parietal cortex and superior temporal cortex, while their unaffected first-degree siblings only showed reduced local connectivity in the PCC.ConclusionsThese findings suggest that the disruptions of default network functional connectivity might be associated with family history of OCD. The decreased default network connectivity in both OCD patients and their unaffected siblings may serve as a potential marker of OCD.

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