Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder

2005 ◽  
Vol 21 (3) ◽  
pp. 135-139 ◽  
Author(s):  
Heon-Jeong Lee ◽  
Min-Soo Lee ◽  
Rhee-Hun Kang ◽  
Hyun Kim ◽  
Soon-Duck Kim ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Gene Polymorphism ◽  
Posttraumatic Stress ◽  
Serotonin Transporter ◽  
Stress Disorder ◽  
Promoter Gene

scholarly journals Reduced Amygdala Serotonin Transporter Binding in Posttraumatic Stress Disorder

2011 ◽  
Vol 70 (11) ◽  
pp. 1033-1038 ◽  
Author(s):  
James W. Murrough ◽  
Yiyun Huang ◽  
Jian Hu ◽  
Shannan Henry ◽  
Wendol Williams ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Serotonin Transporter ◽  
Stress Disorder

scholarly journals Association of BDNF gene polymorphism with endophenotypes in posttraumatic stress disorder

2020 ◽  
Vol 66 (5) ◽  
pp. 615-622
Author(s):  
Jun-Cheng Guo ◽  
Xiang Li ◽  
Min Guo ◽  
Yun-Suo Gao ◽  
Lin-Qiu Fu ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Gene Polymorphism ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Polyacrylamide Gel Electrophoresis ◽  
Bdnf Gene ◽  
Chain Reaction ◽  
Significant Difference ◽  
Polymerase Chain ◽  
Ptsd Group

SUMMARY OBJECTIVE To explore the association of brain-derived neurotrophic factor gene (BDNF) polymorphism with the latent cognitive endophenotype of posttraumatic stress disorder (PTSD) after major natural disasters in Hainan Province, China. METHODS A total of 300 patients with PTSD and 150 healthy controls (HC) were surveyed by psychoanalysis scale to assess their cognitive functions. Polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE) were used to detect the BDNF gene polymorphism. RESULTS In terms of the cognitive function, the scores in the PTSD group were worse than those of the HC group (P < 0.05 or P < 0.01). There was a significant difference in the distribution of BDNF genotype and allele frequency between the two groups (P < 0.05). PTSD endophenotypes were significantly different among the BDNF genotypes in the PTSD group (P ≤ 0.01). CONCLUSION There is a statistically significant difference in the polymorphism of BDNF gene between PTSD and HC groups, and the alleles are associated with the incidence of PTSD. Thus, it may be a risk factor for PTSD.

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