Clinical correlates of recurrent major depression in obsessive-compulsive disorder

2004 ◽  
Vol 20 (2) ◽  
pp. 86-91 ◽  
Author(s):  
Jin Pyo Hong ◽  
Jack Samuels ◽  
O. Joseph Bienvenu ◽  
Paul Cannistraro ◽  
Marco Grados ◽  
...  
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates

Komorbidität von Zwangsstörungen und Major Depression: Rolle der HPA-Achse

2019 ◽  
Vol 87 (12) ◽  
pp. 677-678
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Symptome einer schweren Depression (Major Depression, MD) treten häufig begleitend zu anderen psychiatrischen Erkrankungen wie Zwangsstörungen (Obsessive Compulsive Disorder, OCD) auf. Die hohe Komorbidität zwischen MD und OCD weist auf überlappende Krankheitsmechanismen hin. Für beide Erkrankungen sind Veränderungen in der Hypothalamus-Hypophysen-Nebennierenrinden (HPA)-Achse beschrieben worden.

scholarly journals Symmetry Dimension in Obsessive–Compulsive Disorder: Prevalence, Severity and Clinical Correlates

2021 ◽  
Vol 10 (2) ◽  
pp. 274
Author(s):  
Aline P. Vellozo ◽  
Leonardo F. Fontenelle ◽  
Ricardo C. Torresan ◽  
Roseli G. Shavitt ◽  
Ygor A. Ferrão ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Obsessive Compulsive Disorder ◽  
Clinical Sample ◽  
Cross Sectional Study ◽  
Obsessive Compulsive ◽  
Chi Square ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Axis I

Background: Obsessive–compulsive disorder (OCD) is a very heterogeneous condition that frequently includes symptoms of the “symmetry dimension” (i.e., obsessions and/or compulsions of symmetry, ordering, repetition, and counting), along with aggressive, sexual/religious, contamination/cleaning, and hoarding dimensions. Methods: This cross-sectional study aimed to investigate the prevalence, severity, and demographic and clinical correlates of the symmetry dimension among 1001 outpatients from the Brazilian Research Consortium on Obsessive–Compulsive Spectrum Disorders. The main assessment instruments used were the Dimensional Yale–Brown Obsessive–Compulsive Scale, the Yale–Brown Obsessive–Compulsive Scale, the USP-Sensory Phenomena Scale, the Beck Depression and Anxiety Inventories, the Brown Assessment of Beliefs Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Chi-square tests, Fisher’s exact tests, Student’s t-tests, and Mann–Whitney tests were used in the bivariate analyses to compare patients with and without symptoms of the symmetry dimension. Odds ratios (ORs) with confidence intervals and Cohen’s D were also calculated as effect size measures. Finally, a logistic regression was performed to control for confounders. Results: The symmetry dimension was highly prevalent (86.8%) in this large clinical sample and, in the logistic regression, it remained associated with earlier onset of obsessive–compulsive symptoms, insidious onset of compulsions, more severe depressive symptoms, and presence of sensory phenomena. Conclusions: A deeper knowledge about specific OCD dimensions is essential for a better understanding and management of this complex and multifaceted disorder.

Clinical correlates of caudate volume in drug-naïve adult patients with obsessive–compulsive disorder

2013 ◽  
Vol 212 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Janardhanan C. Narayanaswamy ◽  
Dania A. Jose ◽  
Sunil V. Kalmady ◽  
Ganesan Venkatasubramanian ◽  
Y.C. Janardhana Reddy
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Adult Patients ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Drug Naïve

Increased serum drug concentrations in concomitant treatment with citalopram, clomipramine and alprazolam

1994 ◽  
Vol 9 (6) ◽  
pp. 312-314
Author(s):  
U Lepola ◽  
E Leinonen ◽  
H Koponen
Keyword(s):  
Cytochrome P450 ◽  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Oxidative Metabolism ◽  
Competitive Inhibition ◽  
High Serum ◽  
Concomitant Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Drug Concentrations

SummaryWe report the case of a patient with major depression and obsessive-compulsive disorder who had simultaneously high serum citalopram, clomipramine, and alprazolam concentrations probably due to the reciprocal competitive inhibition of the cytochrome P450-catalyzed oxidative metabolism.

Unilateral right anterior capsulotomy for refractory major depression with comorbid obsessive–compulsive disorder

Neurocase ◽  
2011 ◽  
Vol 17 (6) ◽  
pp. 491-500 ◽  
Author(s):  
Alonso R. Riestra ◽  
Jaime Aguilar ◽  
Gerardo Zambito ◽  
Gabriela Galindo y Villa ◽  
Fernando Barrios ◽  
...  
Keyword(s):  
Major Depression ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Anterior Capsulotomy
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