scholarly journals OMIP 077: Definition of all principal human leukocyte populations using a broadly applicable 14‐color panel

2021 ◽  
Author(s):  
Maximilian Boesch ◽  
Martina Sykora ◽  
Silvia Gasteiger ◽  
Florent Baty ◽  
Martin H. Brutsche ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Definition Of ◽  
Leukocyte Populations

Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: Cellular distribution in human leukocyte populations and evidence of diurnal modulation

2011 ◽  
Vol 411 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Alain Veilleux ◽  
W. Cameron Black ◽  
Jacques Yves Gauthier ◽  
Christophe Mellon ◽  
M. David Percival ◽  
...  
Keyword(s):  
Whole Blood ◽  
Human Leukocyte ◽  
Cathepsin S ◽  
Cellular Distribution ◽  
Leukocyte Populations

Differential expression of Raf-1 protooncogene in resting and activated human leukocyte populations

1991 ◽  
Vol 194 (2) ◽  
pp. 284-288 ◽  
Author(s):  
Francesco Colotta ◽  
Nadia Polentarutti ◽  
Alberto Mantovani
Keyword(s):  
Differential Expression ◽  
Human Leukocyte ◽  
Leukocyte Populations

scholarly journals Epitope-Level Matching—A Review of the Novel Concept of Eplets in Transplant Histocompatibility

2021 ◽  
Vol 2 (3) ◽  
pp. 336-347
Author(s):  
André Renaldo ◽  
Adriel Roa-Bautista ◽  
Elena González-López ◽  
Marcos López-Hoyos ◽  
David San Segundo
Keyword(s):  
De Novo ◽  
Graft Loss ◽  
Solid Organ Transplantation ◽  
Human Leukocyte ◽  
Future Research ◽  
Solid Organ ◽  
Leukocyte Antigen ◽  
Definition Of ◽  
Novel Concept ◽  
Hla Compatibility

The development of de novo donor-specific antibodies is related to the poor matching of the human leukocyte antigen (HLA) between donor and recipient, which leads to dismal clinical outcomes and graft loss. However, new approaches that stratify the risks of long-term graft failure in solid organ transplantation have emerged, changing the paradigm of HLA compatibility. In addition, advances in software development have given rise to a new structurally based algorithm known as HLA Matchmaker, which determines compatibility at the epitope rather than the antigen level. Although this technique still has limitations, plenty of research maintains that this assessment represents a more complete and detailed definition of HLA compatibility. This review summarizes recent aspects of eplet mismatches, highlighting the most recent advances and future research directions.

scholarly journals Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses

Blood ◽  
1977 ◽  
Vol 49 (6) ◽  
pp. 855-864 ◽  
Author(s):  
CJ Gregory ◽  
AC Eaves
Keyword(s):  
Pluripotent Stem Cells ◽  
Methyl Cellulose ◽  
Human Leukocyte ◽  
Primitive Cell ◽  
Cell Type ◽  
Close Relationship ◽  
Definition Of ◽  
Nonadherent Cells ◽  
Marrow Cells

Abstract A systematic study has been undertaken to analyze the spectrum of erythropoietic colonies obtained in cultures of human marrow cells plated in methyl cellulose. Colonies were identified as erythropoietic on the basis of the appearance in them of hemoglobin-containing erythroblasts. As found previously in mouse marrow cultures, three sequentially appearing types of colonies which differed in their ultimate cluster content could be readily distinguished. Small erythroid colonies containing 1–2 clusters reached a peak after 7–8 days; small bursts containing 3–8 clusters reached a peak after 10–12 days; and large bursts containing greater than 16 clusters reached a peak after 17–20 days. The previously reported enhancing effect of human leukocyte conditioned medium on burst formation seen in cultures of human nonadherent cells was found to be due largely to an effect on the formation of the largest, late appearing type of burst. By analogy with the mouse, the progenitors of such bursts would represent a primitive cell type which has a close relationship with pluripotent stem cells, as well as a second and independent close relationship to the progenitors of granulopoietic colonies.

scholarly journals Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule.

1981 ◽  
Vol 153 (4) ◽  
pp. 753-765 ◽  
Author(s):  
R Dalchau ◽  
J W Fabre
Keyword(s):  
Monoclonal Antibody ◽  
B Lymphocyte ◽  
Human Leukocyte ◽  
Affinity Column ◽  
Discrete Population ◽  
And Function ◽  
Leukocyte Populations ◽  
Inhibition Studies ◽  
Cross Inhibition ◽  
Functional Consideration

Initial studies with the monoclonal antibody F8-11-13 described in this paper showed that it reacted strongly with B lymphocytes, did not react at all with granulocytes, and reacted only weakly with a small subpopulation of thymocytes and peripheral T lymphocytes. This picture was entirely different from that seen with monoclonal antibodies to the leukocyte common (LC) antigen, where 100% of all the above-mentioned leukocyte populations were positive. Biochemical studies using detergent solubilized membranes labeled with 3H at the sialic acid residues showed that the molecule bearing the F8-11-13 determinant was a glycoprotein of 215,000 mol wt, and that the peak depleted by F8-11-13 monoclonal antibody affinity columns corresponded to the high molecular weight region of a broad peak previously shown to be completely depleted by monoclonal antibody (F10-89-4) affinity columns directed at the LC antigen. Proof that the F8-11-13 determinant was expressed on some LC molecules was established by cross-inhibition studies with affinity-column-purified and depleted material. This finding of a serologically identifiable conformational or other structural change selectively expressed on the LC molecule of a functionally discrete population of lymphocytes has interesting implications for the structure and function of the LC molecule, and might be relevant to functional consideration of other membrane molecules.

scholarly journals Selective Cytotoxicity of Staphylococcal α-Hemolysin (α-Toxin) against Human Leukocyte Populations

2019 ◽  
Vol 42 (6) ◽  
pp. 982-988 ◽  
Author(s):  
Makoto Tsuiji ◽  
Kazuyuki Shiohara ◽  
Yoshinori Takei ◽  
Yoshinori Shinohara ◽  
Shigeyoshi Nemoto ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Selective Cytotoxicity ◽  
Leukocyte Populations
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