scholarly journals A reduction in the vascular smooth muscle cell focal adhesion component syndecan‐4 is associated with abdominal aortic aneurysm formation

2021 ◽  
Vol 11 (12) ◽  
Author(s):  
Jiaxin Hu ◽  
Yuyu Li ◽  
Zhonghai Wei ◽  
Haiting Chen ◽  
Xuan Sun ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Focal Adhesion ◽  
Abdominal Aortic ◽  
Adhesion Component

scholarly journals Variants of Focal Adhesion Scaffold Genes Cause Thoracic Aortic Aneurysm

2021 ◽  
Vol 128 (1) ◽  
pp. 8-23
Author(s):  
Yang Li ◽  
Shijuan Gao ◽  
Yingchun Han ◽  
Li Song ◽  
Yu Kong ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Aortic Aneurysm ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Candidate Genes ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Focal Adhesion ◽  
Thoracic Aortic Aneurysm ◽  
Functional Variants

Rationale: Thoracic aortic aneurysm (TAA) leads to substantial mortality worldwide. Familial and syndromic TAAs are highly correlated with genetics. However, the incidence of sporadic isolated TAA (iTAA) is much higher, and the genetic contribution is not yet clear. Objective: Here, we examined the genetic characteristics of sporadic iTAA. Methods and Results: We performed a genetic screen of 551 sporadic iTAA cases and 1071 controls via whole-exome sequencing. The prevalence of pathogenic mutations in known causal genes was 5.08% in the iTAA cohort. We selected 100 novel candidate genes using a strict strategy, and the suspected functional variants of these genes were significantly enriched in cases compared with controls and carried by 60.43% of patients. We found more severe phenotypes and a lower proportion of hypertension in cases with pathogenic mutations or suspected functional variants. Among the candidate genes, Testin ( TES ), which encodes a focal adhesion scaffold protein, was identified as a potential TAA causal gene, accounting for 4 patients with 2 missense variants in the LIM1 domain (c.751T>C encoding p.Y251H; c.838T>C encoding p.Y280H) and highly expressed in the aorta. The 2 variants led to a decrease in TES expression. The thoracic aorta was spontaneously dilated in the Tes Y249H knock-in and Tes −/− mice. Mechanistically, the p.Y249H variant or knockdown of TES led to the repression of vascular smooth muscle cell contraction genes and disturbed the vascular smooth muscle cell contractile phenotype. Interestingly, suspected functional variants of other focal adhesion scaffold genes, including TLN1 (Talin-1) and ZYX (zyxin), were also significantly enriched in patients with iTAA; moreover, their knockdown resulted in decreased contractility of vascular smooth muscle cells. Conclusions: For the first time, this study revealed the genetic landscape across iTAA and showed that the focal adhesion scaffold genes are critical in the pathogenesis of iTAA.

Vascular smooth muscle cell remodelling in elastase-induced aortic aneurysm

2010 ◽  
Vol 65 (5) ◽  
pp. 499-506 ◽  
Author(s):  
Lei Jiao ◽  
Zheng Xu ◽  
Feng Xu ◽  
Shiming Zhang ◽  
Kaiyun Wu
Keyword(s):  
Smooth Muscle ◽  
Aortic Aneurysm ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell

scholarly journals Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease

2017 ◽  
Vol 55 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Kirsten Riches ◽  
Emily Clark ◽  
Rebecca J. Helliwell ◽  
Timothy G. Angelini ◽  
Karen E. Hemmings ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Phenotype ◽  
Progressive Development ◽  
Abdominal Aortic ◽  
Smooth Muscle Cell Phenotype

scholarly journals Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0178538 ◽  
Author(s):  
Jaspreet Sachdeva ◽  
Advitiya Mahajan ◽  
Jeeyun Cheng ◽  
Jeremy T. Baeten ◽  
Brenda Lilly ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Abdominal Aortic
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