scholarly journals RNA N 6 ‐methyladenosine modification in the lethal teamwork of cancer stem cells and the tumor immune microenvironment: Current landscape and therapeutic potential

2021 ◽  
Vol 11 (9) ◽  
Author(s):  
Zhihui Zhang ◽  
Chaoqi Zhang ◽  
Yuejun Luo ◽  
Guochao Zhang ◽  
Peng Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Potential ◽  
Immune Microenvironment ◽  
Tumor Immune Microenvironment

Natural products targeting cancer stem cells: a revisit

2021 ◽  
Vol 28 ◽  
Author(s):  
Jiahua Cui ◽  
Jiajun Qian ◽  
Larry Ming-Cheung Chow ◽  
Jinping Jia
Keyword(s):  
Stem Cells ◽  
Drug Resistance ◽  
Natural Products ◽  
Cancer Stem Cells ◽  
Therapeutic Potential ◽  
Tumor Development ◽  
Biologically Active ◽  
Cellular Targets ◽  
Drug Candidates ◽  
Enhanced Expression

Background: The proposed central role of cancer stem cells (CSCs) in tumor development has been extended to explain the diverse oncologic phenomena such as multidrug resistance, metastasis and tumor recurrence in clinics. Due to the enhanced expression of ATP-binding cassette transporters and anti-apoptotic factors, stagnation on G0 phase and the strong ability of self-renewal, the CSCs were highly resistant to clinical anticancer drugs. Therefore, the discovery of new drug candidates that could effectively eradicate cancer stem cells afforded promising outcomes in cancer therapy. Introduction: Natural products and their synthetic analogues are a rich source of biologically active compounds and several of them have already been recognized as potent CSCs killers. We aim to provide a collection of recently identified natural products that suppressed the survival of the small invasive CSC populations and combated the drug resistance of these cells in chemotherapy. Results and Conclusion: These anti-CSCs natural products included flavonoids, stilbenes, quinones, terpenoids, polyketide antibiotics, steroids and alkaloids. In the present review, we highlighted the therapeutic potential of natural products and their derivatives against the proliferation and drug resistance of CSCs, their working mechanisms and related structure-activity relationships. Meanwhile, in this survey, several natural products with diverse cellular targets such as the naphthoquinone shikonin and the stilbene resveratrol were characterized as promising lead compounds for future development.

scholarly journals Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

Biomedicines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 7 ◽  
Author(s):  
Lingfeng Fu ◽  
Luke Bu ◽  
Tadahito Yasuda ◽  
Mayu Koiwa ◽  
Takahiko Akiyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Chemotherapy Resistance ◽  
Immune Microenvironment ◽  
Self Renewal ◽  
Current Review ◽  
Gastric Cancer Stem Cells ◽  
Novel Therapeutic Strategies ◽  
The Relationship

Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs.

scholarly journals Long Non-Coding RNAs in the Tumor Immune Microenvironment: Biological Properties and Therapeutic Potential

2021 ◽  
Vol 12 ◽  
Author(s):  
Ya-Nan Pi ◽  
Wen-Cai Qi ◽  
Bai-Rong Xia ◽  
Ge Lou ◽  
Wei-Lin Jin
Keyword(s):  
Therapeutic Potential ◽  
Immune Surveillance ◽  
Biological Properties ◽  
Immune Microenvironment ◽  
Protein Coding ◽  
Innate And Adaptive Immunity ◽  
Non Coding Rna ◽  
Tumor Immune Microenvironment ◽  
Immunosuppressive Microenvironment ◽  
Long Non Coding Rna

Cancer immunotherapy (CIT) is considered a revolutionary advance in the fight against cancer. The complexity of the immune microenvironment determines the success or failure of CIT. Long non-coding RNA (lncRNA) is an extremely versatile molecule that can interact with RNA, DNA, or proteins to promote or inhibit the expression of protein-coding genes. LncRNAs are expressed in many different types of immune cells and regulate both innate and adaptive immunity. Recent studies have shown that the discovery of lncRNAs provides a novel perspective for studying the regulation of the tumor immune microenvironment (TIME). Tumor cells and the associated microenvironment can change to escape recognition and elimination by the immune system. LncRNA induces the formation of an immunosuppressive microenvironment through related pathways, thereby controlling the escape of tumors from immune surveillance and promoting the development of metastasis and drug resistance. Using lncRNA as a therapeutic target provides a strategy for studying and improving the efficacy of immunotherapy.

Therapeutic Potential, Challenges and Future Perspective of Cancer Stem Cells in Translational Oncology: A Critical Review

2017 ◽  
Vol 12 (3) ◽  
pp. 207-224 ◽  
Author(s):  
Gaurav Shukla ◽  
Harvinder Khera ◽  
Amit Srivastava ◽  
Piush Khare ◽  
Rahul Patidar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Critical Review ◽  
Therapeutic Potential ◽  
Future Perspective ◽  
Translational Oncology

Therapeutic potential of cancer stem cells

2015 ◽  
Vol 32 (6) ◽  
Author(s):  
Chunguang Yang ◽  
Kunlin Jin ◽  
Yangping Tong ◽  
William Chi Cho
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Potential
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