scholarly journals Primary nonfunction following liver transplantation: Learning of graft metabolites and building a predictive model

2021 ◽  
Vol 11 (7) ◽  
Author(s):  
Xueyou Zhang ◽  
Cheng Zhang ◽  
Haitao Huang ◽  
Ruihan Chen ◽  
Yimou Lin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Predictive Model ◽  
Primary Nonfunction

A predictive model for acute allograft rejection of liver transplantation

2018 ◽  
Vol 94 ◽  
pp. 228-236 ◽  
Author(s):  
Chien-Liang Liu ◽  
Ruey-Shyang Soong ◽  
Wei-Chen Lee ◽  
De-Hsuan Chen ◽  
Shang-Hwa Hsu
Keyword(s):  
Liver Transplantation ◽  
Predictive Model ◽  
Allograft Rejection ◽  
Acute Allograft Rejection

Predictive model for microvascular invasion of hepatocellular carcinoma among candidates for either hepatectomy or liver transplantation.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 4079-4079
Author(s):  
Hidetoshi Nitta ◽  
Marc Antoine Allard ◽  
Mylene Sebagh ◽  
Gabriella Pittau ◽  
Oriana Ciacio ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Predictive Model ◽  
Validation Cohort ◽  
Microvascular Invasion ◽  
Roc Curve Analysis ◽  
Training Cohort ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct

4079 Background: Microvascular invasion (MVI) is the strongest prognostic factor following surgery of hepatocellular carcinoma (HCC). However, it is usually not available on the preoperative setting. A predictive model of MVI in patients scheduled for hepatic resection (HR) or liver transplantation (LT) would thus help guiding treatment strategy. The aim of this study was to develop a predictive model for MVI of HCC before either HR or LT. Methods: HCC patients who consecutively performed HR or LT from January 1994 to June 2016 at a single institution were subdivided into a training and validation cohort. Risk factors for MVI in the training cohort were used to develop a predictive model for MVI, to be validated in the validation cohort. The outcomes of the HR and LT patients with high or low MVI probability based on the model, were compared using propensity score matching (PSM). Cut-off values for continuous factors were determined based on ROC curve analysis. Results: A total of 910 patients (425 HR, 485 LT) were included in the training (n = 637) and validation (n = 273) cohorts. In the training cohort, multivariate analysis demonstrated that alpha-fetoprotein ≥100ng/ml ( p < 0.0001), largest tumor size ≥40mm ( p = 0.0002), non-boundary HCC type on contrast-enhanced CT ( p = 0.001), neutrophils-to-lymphocytes ratio ≥3.2 ( p = 0.002), aspartate aminotransferase ≥62U/l ( p = 0.02) were independently associated with MVI. Combinations of these 5 factors varied the MVI probability from 15.5% to 91.1%. This predictive model achieved a good c-index of 0.76 in the validation cohort. In PSM (109 HR, 109 LT), there was no difference in survival between HR and LT patients among the high MVI probability (≥50%) patients, (5y-OS; 46.3% vs 42.2%, p = 0.77, 5y-RFS; 54.0% vs 28.8%, p = 0.21). Among the low probability ( < 50%), survival was significantly decreased following HR compared with LT (5y-OS; 54.1% vs 78.8%, p = 0.007, 5y-RFS; 17.3% vs 86.1%, p< 0.0001). Conclusions: This model developed from preoperative data allows reliable prediction of MVI, and may thus help with preoperative decisions about the suitability of HR or LT in patients with HCC.

scholarly journals Development of a Predictive Model for Hyperglycemia in Nondiabetic Recipients After Liver Transplantation

2018 ◽  
Vol 4 (10) ◽  
pp. e393
Author(s):  
Henry Zelada ◽  
Lisa B. VanWagner ◽  
Teresa Pollack ◽  
Devan Higginbotham ◽  
Lihui Zhao ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Predictive Model

Development of a Predictive Model for Blood Transfusions and Bleeding During Liver Transplantation: An Observational Cohort Study

2018 ◽  
Vol 32 (4) ◽  
pp. 1722-1730 ◽  
Author(s):  
Luc Massicotte ◽  
François Martin Carrier ◽  
André Y. Denault ◽  
Pierre Karakiewicz ◽  
Zoltan Hevesi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Cohort Study ◽  
Predictive Model ◽  
Observational Cohort Study ◽  
Blood Transfusions ◽  
Observational Cohort

O104 : Predictive model for the need for liver transplantation in symptomatic polycystic liver disease

2015 ◽  
Vol 62 ◽  
pp. S245-S246
Author(s):  
F. Temmerman ◽  
M. Oliverius ◽  
J. Lerut ◽  
J.P. Drenth ◽  
H. Metselaar ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Predictive Model ◽  
Polycystic Liver Disease ◽  
Polycystic Liver

scholarly journals Predictive model for microvascular invasion of hepatocellular carcinoma among candidates for either hepatic resection or liver transplantation

Surgery ◽  
2019 ◽  
Vol 165 (6) ◽  
pp. 1168-1175 ◽  
Author(s):  
Hidetoshi Nitta ◽  
Marc-Antoine Allard ◽  
Mylène Sebagh ◽  
Vincent Karam ◽  
Oriana Ciacio ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Hepatic Resection ◽  
Predictive Model ◽  
Microvascular Invasion

Donor infection and primary nonfunction in liver transplantation

1997 ◽  
Vol 29 (1-2) ◽  
pp. 481-483 ◽  
Author(s):  
J.R. Nery ◽  
D. Weppler ◽  
L. Olson ◽  
G.P. Fragulidis ◽  
M.F. Khan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Primary Nonfunction

scholarly journals Early diagnosis of primary nonfunction and indication for reoperation after liver transplantation

2010 ◽  
Vol 16 (2) ◽  
pp. 172-180 ◽  
Author(s):  
Johan Friso Lock ◽  
Eugen Schwabauer ◽  
Peter Martus ◽  
Nikolay Videv ◽  
Johann Pratschke ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Early Diagnosis ◽  
Primary Nonfunction
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