scholarly journals Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation

2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Anet Laanesoo ◽  
Egon Urgard ◽  
Kapilraj Periyasamy ◽  
Martti Laan ◽  
Yury A. Bochkov ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
Asthma Exacerbation ◽  
Dual Role

Dual role of IL-17 in allergic asthma

2009 ◽  
pp. 95-104
Author(s):  
Bruno Schnyder ◽  
Silvia Schnyder-Candrian
Keyword(s):  
Allergic Asthma ◽  
Dual Role

Dual Role of IL-22 in Allergic Airway Inflammation and its Cross-talk with IL-17A

2011 ◽  
Vol 183 (9) ◽  
pp. 1153-1163 ◽  
Author(s):  
Anne-Gaelle Besnard ◽  
Robert Sabat ◽  
Laure Dumoutier ◽  
Jean-Christophe Renauld ◽  
Monique Willart ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Cross Talk ◽  
Allergic Airway Inflammation ◽  
Dual Role

IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice

2012 ◽  
Vol 302 (4) ◽  
pp. L429-L440 ◽  
Author(s):  
Kyung-Ah Cho ◽  
Jee Won Suh ◽  
Jung Ho Sohn ◽  
Jung Won Park ◽  
Hyejin Lee ◽  
...  
Keyword(s):  
Mast Cells ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Th2 Cytokine ◽  
Cytokine Levels ◽  
Th17 Differentiation ◽  
Deficient Mice ◽  
Important Cytokine

Allergic asthma is characterized by infiltration of eosinophils, elevated Th2 cytokine levels, airway hyperresponsiveness, and IgE. In addition to eosinophils, mast cells, and basophils, a variety of cytokines are also involved in the development of allergic asthma. The pivotal role of eosinophils in the progression of the disease has been a subject of controversy. To determine the role of eosinophils in the progression of airway inflammation, we sensitized and challenged BALB/c wild-type (WT) mice and eosinophil-deficient ΔdblGATA mice with ovalbumin (OVA) and analyzed different aspects of inflammation. We observed increased eosinophil levels and a Th2-dominant response in OVA-challenged WT mice. In contrast, eosinophil-deficient ΔdblGATA mice displayed an increased proportion of mast cells and a Th17-biased response following OVA inhalation. Notably, the levels of IL-33, an important cytokine responsible for Th2 immune deviation, were not different between WT and eosinophil-deficient mice. We also demonstrated that mast cells induced Th17-differentiation via IL-33/ST2 stimulation in vitro. These results indicate that eosinophils are not essential for the development of allergic asthma and that mast cells can skew the immune reaction predominantly toward Th17 responses via IL-33 stimulation.

Role Of Interleukine-33 In Rhinovirus-Induced Allergic Asthma Exacerbation

2014 ◽  
Vol 133 (2) ◽  
pp. AB52
Author(s):  
Marie Toussaint ◽  
Aran Singanayagam ◽  
Sebastian L. Johnston ◽  
Nathan Bartlett
Keyword(s):  
Allergic Asthma ◽  
Asthma Exacerbation

scholarly journals Irg1/itaconate metabolic pathway is a crucial determinant of dendritic cells immune-priming function and contributes to resolute allergen-induced airway inflammation

2021 ◽  
Author(s):  
Anil Kumar Jaiswal ◽  
Jyoti Yadav ◽  
Sangeet Makhija ◽  
Suman Mazumder ◽  
Amit Kumar Mitra ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Allergic Asthma ◽  
Allergic Sensitization ◽  
Mucous Cell ◽  
Th2 Immune Response ◽  
Pulsed Dc

AbstractItaconate is produced from the mitochondrial TCA cycle enzyme aconitase decarboxylase (encoded by immune responsive gene1; Irg1) that exerts immunomodulatory function in myeloid cells. However, the role of the Irg1/itaconate pathway in dendritic cells (DC)-mediated airway inflammation and adaptive immunity to inhaled allergens, which are the primary antigen-presenting cells in allergic asthma, remains largely unknown. House dust mite (HDM)-challenged Irg1−/− mice displayed increases in eosinophilic airway inflammation, mucous cell metaplasia, and Th2 cytokine production with a mechanism involving impaired mite antigen presentations by DC. Adoptive transfer of HDM-pulsed DC from Irg1-deficient mice into naïve WT mice induced a similar phenotype of elevated type 2 airway inflammation and allergic sensitization. Untargeted metabolite analysis of HDM-pulsed DC revealed itaconate as one of the most abundant polar metabolites that potentially suppress mitochondrial oxidative damage. Furthermore, the immunomodulatory effect of itaconate was translated in vivo, where intranasal administration of 4-octyl itaconate 4-OI following antigen priming attenuated the manifestations of HDM-induced airway disease and Th2 immune response. Taken together, these data demonstrated for the first time a direct regulatory role of the Irg1/itaconate pathway in DC for the development of type 2 airway inflammation and suggest a possible therapeutic target in modulating allergic asthma.

A dual role of C5a for initial CD11b+ dendritic cell accumulation and activation in experimental allergic asthma

Immunobiology ◽  
2016 ◽  
Vol 221 (10) ◽  
pp. 1192
Author(s):  
Fanny Ender ◽  
Anna V. Wiese ◽  
Tillman Vollbrandt ◽  
Jörg Köhl ◽  
Yves Laumonnier
Keyword(s):  
Dendritic Cell ◽  
Allergic Asthma ◽  
Dual Role ◽  
Cell Accumulation ◽  
Experimental Allergic Asthma ◽  
Experimental Allergic
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