scholarly journals Suppression of lncRNA MALAT1 by betulinic acid inhibits hepatocellular carcinoma progression by targeting IAPs via miR‐22‐3p

2020 ◽  
Vol 10 (6) ◽  
Author(s):  
Feiyu Chen ◽  
Zhangfeng Zhong ◽  
Hor Yue Tan ◽  
Wei Guo ◽  
Cheng Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Betulinic Acid ◽  
Lncrna Malat1

scholarly journals LncRNA MALAT1 acts as a miR-125a-3p sponge to regulate FOXM1 expression and promote hepatocellular carcinoma progression

2019 ◽  
Vol 10 (26) ◽  
pp. 6649-6659 ◽  
Author(s):  
Shihai Liu ◽  
Jing Qiu ◽  
Guifang He ◽  
Ye Liang ◽  
Liping Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lncrna Malat1 ◽  
Foxm1 Expression

Synthesis of a new betulinic acid glycoconjugate with N-acetyl-d-galactosamine for the targeted delivery to hepatocellular carcinoma cells

2020 ◽  
Vol 69 (1) ◽  
pp. 158-163
Author(s):  
A. S. Olshanova ◽  
E. Yu. Yamansarov ◽  
E. I. Seleznev ◽  
S. V. Kovalev ◽  
A. V. Lopuhov ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Betulinic Acid ◽  
Targeted Delivery ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shu-Juan Xie ◽  
Li-Ting Diao ◽  
Nan Cai ◽  
Li-Ting Zhang ◽  
Sha Xiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Mammalian Cells ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Migration And Invasion ◽  
Clinical Samples ◽  
Erk Mapk ◽  
Lncrna Malat1 ◽  
Hcc Cells

AbstractMALAT1-associated small cytoplasmic RNA (mascRNA) is a cytoplasmic tRNA-like small RNA derived from nucleus-located long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). While MALAT1 was extensively studied and was found to function in multiple cellular processes, including tumorigenesis and tumor progression, the role of mascRNA was largely unknown. Here we show that mascRNA is upregulated in multiple cancer cell lines and hepatocellular carcinoma (HCC) clinical samples. Using HCC cells as model, we found that mascRNA and its parent lncRNA MALAT1 can both promote cell proliferation, migration, and invasion in vitro. Correspondingly, both of them can enhance the tumor growth in mice subcutaneous tumor model and can promote metastasis by tail intravenous injection of HCC cells. Furthermore, we revealed that mascRNA and MALAT1 can both activate ERK/MAPK signaling pathway, which regulates metastasis-related genes and may contribute to the aggressive phenotype of HCC cells. Our results indicate a coordination in function and mechanism of mascRNA and MALAT1 during development and progress of HCC, and provide a paradigm for deciphering tRNA-like structures and their parent transcripts in mammalian cells.

p53-p66shc/miR-21-Sod2 signaling is critical for the inhibitory effect of betulinic acid on hepatocellular carcinoma

2015 ◽  
Vol 238 (3) ◽  
pp. 1-10 ◽  
Author(s):  
Jingyue Yang ◽  
Bo Qiu ◽  
Xiao Li ◽  
Hongmei Zhang ◽  
Wenchao Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Betulinic Acid ◽  
Inhibitory Effect

scholarly journals miR‐124‐3p availability is antagonized by LncRNA‐MALAT1 for Slug‐induced tumor metastasis in hepatocellular carcinoma

2019 ◽  
Vol 8 (14) ◽  
pp. 6358-6369 ◽  
Author(s):  
Rong‐Jun Cui ◽  
Jia‐Lin Fan ◽  
Yu‐Cui Lin ◽  
Yu‐Jia Pan ◽  
Chi Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Metastasis ◽  
Lncrna Malat1
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