scholarly journals Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Thina H Kailaivasan ◽  
Victoria L Timbrell ◽  
Graham Solley ◽  
William B Smith ◽  
Andrew McLean‐Tooke ◽  
...  
1998 ◽  
Vol 101 (2) ◽  
pp. 258-264 ◽  
Author(s):  
Verena Niederberger ◽  
Sylvia Laffer ◽  
Renate Fröschl ◽  
Dietrich Kraft ◽  
Helmut Rumpold ◽  
...  

2009 ◽  
Vol 124 (5) ◽  
pp. 1005-1011.e1 ◽  
Author(s):  
Carmen Rondón ◽  
Javier Fernández ◽  
Soledad López ◽  
Paloma Campo ◽  
Inmaculada Doña ◽  
...  

2007 ◽  
Vol 119 (1) ◽  
pp. S78
Author(s):  
J.M. de la Borbolla ◽  
R. Escudero ◽  
J. Antón ◽  
M.J. Goikoetxea ◽  
M.L. Sanz ◽  
...  

2015 ◽  
Vol 450 ◽  
pp. 46-50 ◽  
Author(s):  
Erna Van Hoeyveld ◽  
Silvie Nickmans ◽  
Jan L. Ceuppens ◽  
Xavier Bossuyt

2016 ◽  
Vol 78 ◽  
pp. 105-112 ◽  
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Wenting Luo ◽  
Huimin Huang ◽  
Peiyan Zheng ◽  
Nili Wei ◽  
Jiaying Luo ◽  
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2020 ◽  
Vol 41 (5) ◽  
pp. 357-362
Author(s):  
Laura Schiavi ◽  
Giulia Brindisi ◽  
Giovanna De Castro ◽  
Valentina De Vittori ◽  
Lorenzo Loffredo ◽  
...  

Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home administration, which improves patient comfort and compliance. Objective: The primary outcome of this study was to assess the change in nasal reactivity after grass-pollen AIT treatment. Methods: This was a monocentric, prospective, observational study conducted in Rome from September 2016 to June 2018, in the Pediatric Department of Policlinico Umberto I. We enrolled children, ages between 6 and 12 years, with persistent allergic rhinitis (AR), sensitized to grass pollen. At the first visit (V0, September 2016), one group received the first dose of oral immunotherapy for grass-pollen spray buccal and the other group continued only standard therapy. All the patients had nasal specific immunoglobulin I (IgE) assay (Phl p1, Phl p5), active anterior rhinomanometry with a nasal provocation test (NPT), and spirometry. The patients attended two follow-up visits, in May 2017 (V1) and May 2018 (V2), with the same examinations as at V0. Results: During the treatment, we observed, in the treated group, a significant increase in the mean nasal flow compared with untreated children (p < 0.001). In the AIT group, we found an improvement of nasal function and only 21.05% of all the children in the active group with a positive NPT result at V2. In the control group, we found, at V2, a worsening of nasal function, with 89.47% of the children with a positive NPT result. Furthermore, we found a significant reduction of nasal specific IgE levels at the end of the observation period in the treated group. Conclusion: Analysis of our data provided evidence for a clinical effect of SLIT in inducing clinical changes and allergen tolerance in children with AR.


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