scholarly journals Rapid loss of group 1 innate lymphoid cells during blood stagePlasmodiuminfection

2018 ◽  
Vol 7 (1) ◽  
pp. e1003 ◽  
Author(s):  
Susanna S Ng ◽  
Fernando Souza-Fonseca-Guimaraes ◽  
Fabian de Labastida Rivera ◽  
Fiona H Amante ◽  
Rajiv Kumar ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Rapid Loss ◽  
Group 1

scholarly journals CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

2016 ◽  
Vol 196 (5) ◽  
pp. 2051-2062 ◽  
Author(s):  
Florence Roan ◽  
Thomas A. Stoklasek ◽  
Elizabeth Whalen ◽  
Jerry A. Molitor ◽  
Jeffrey A. Bluestone ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 1

scholarly journals Molecular definition of group 1 innate lymphoid cells in the mouse uterus

2018 ◽  
Author(s):  
Iva Filipovic ◽  
Laura Chiossone ◽  
Paola Vacca ◽  
Russell S Hamilton ◽  
Tiziano Ingegnere ◽  
...  
Keyword(s):  
Nk Cells ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Memory Cells ◽  
Mouse Uterus ◽  
Protein Ubiquitination ◽  
Reproductive Life ◽  
Definition Of ◽  
Molecular Patterns ◽  
Group 1

ABSTRACTDetermining the function of uterine lymphocytes is challenging because of the rapidly changing nature of the organ in response to sex hormones and, during pregnancy, to the invading fetal trophoblast cells. Here we provide the first genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (g1 ILCs) at mid-gestation. The composition of g1 ILCs fluctuates throughout reproductive life, with Eomes-veCD49a+ ILC1s dominating before puberty and specifically expanding in second pregnancies, when the expression of CXCR6, a marker of memory cells, is upregulated. Tissue-resident Eomes+CD49a+ NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and showcase gene signatures of responsiveness to TGF-β, connections with trophoblast, epithelial, endothelial and smooth muscle cells, leucocytes, as well as extracellular matrix. Unexpectedly, trNK cells express genes involved in anaerobic glycolysis, lipid metabolism, iron transport, protein ubiquitination, and recognition of microbial molecular patterns. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-γ. These results identify trNK cells as the cellular hub of uterine g1 ILCs at mid-gestation and mark CXCR6+ ILC1s as potential memory cells of pregnancy.

scholarly journals Enteric bacteria induce IFNγ and Granzyme B from human colonic Group 1 Innate Lymphoid Cells

Gut Microbes ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 1667723 ◽  
Author(s):  
Moriah J. Castleman ◽  
Stephanie M. Dillon ◽  
Christine Purba ◽  
Andrew C. Cogswell ◽  
Martin McCarter ◽  
...  
Keyword(s):  
Granzyme B ◽  
Enteric Bacteria ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 1

scholarly journals Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

2016 ◽  
Vol 196 (9) ◽  
pp. 3966-3966 ◽  
Author(s):  
Florence Roan ◽  
Thomas A. Stoklasek ◽  
Elizabeth Whalen ◽  
Jerry A. Molitor ◽  
Jeffrey A. Bluestone ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Group 1

scholarly journals Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway

2018 ◽  
Vol 14 (1) ◽  
pp. e1006819 ◽  
Author(s):  
Juanjuan Zhao ◽  
Liang Cheng ◽  
Hongbo Wang ◽  
Haisheng Yu ◽  
Bo Tu ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Type I ◽  
Interferon Pathway ◽  
Hiv 1 ◽  
Group 1
Sign in / Sign up

Export Citation Format

Share Document