Privileged biorenewable secologanin‐based diversity‐oriented synthesis for pseudo‐natural alkaloids: uncovering novel neuroprotective and antimalarial frameworks

ChemSusChem ◽  
2021 ◽  
Author(s):  
Huajian Zhu ◽  
Yunrui Cai ◽  
Shijia Ma ◽  
Yushi Futamura ◽  
Jinbiao Li ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis

Diversity-oriented synthesis of polymer membranes with ion solvation cages

Nature ◽  
2021 ◽  
Vol 592 (7853) ◽  
pp. 225-231
Author(s):  
Miranda J. Baran ◽  
Mark E. Carrington ◽  
Swagat Sahu ◽  
Artem Baskin ◽  
Junhua Song ◽  
...  
Keyword(s):  
Polymer Membranes ◽  
Ion Solvation ◽  
Diversity Oriented Synthesis

scholarly journals Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Akshaykumar Nayak ◽  
Himani Saxena ◽  
Chandramohan Bathula ◽  
Tarkeshwar Kumar ◽  
Souvik Bhattacharjee ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Small Molecules ◽  
New Drugs ◽  
Developmental Cycle ◽  
Oxygen Species ◽  
Compound Library ◽  
Diversity Oriented Synthesis ◽  
Resistant Strains ◽  
Acid Catalyzed

Abstract Background Despite numerous efforts to eradicate the disease, malaria continues to remain one of the most dangerous infectious diseases plaguing the world. In the absence of any effective vaccines and with emerging drug resistance in the parasite against the majority of anti-malarial drugs, the search for new drugs is urgently needed for effective malaria treatment. Methods The goal of the present study was to examine the compound library, based on indoles generated through diversity-oriented synthesis belonging to four different architecture, i.e., 1-aryltetrahydro/dihydro-β-carbolines and piperidine/pyrrolidine-fused indole derivatives, for their in vitro anti-plasmodial activity. Trifluoroacetic acid catalyzed transformation involving tryptamine and various aldehydes/ketones provided the library. Results Among all the compounds screened, 1-aryltetrahydro-β-carbolines 2 and 3 displayed significant anti-plasmodial activity against both the artemisinin-sensitive and artemisinin-resistant strain of Plasmodium falciparum. It was observed that these compounds inhibited the overall parasite growth in intra-erythrocytic developmental cycle (IDC) via reactive oxygen species-mediated parasitic death and thus could be potential anti-malarial compounds. Conclusion Overall the compounds 2 and 3 identified in this study shows promising anti-plasmodial activity that can kill both artemisinin-sensitive and artemisinin-resistant strains of P. falciparum.

Diversity-Oriented Synthesis of Tamoxifen-type Tetrasubstituted Olefins

2003 ◽  
Vol 125 (48) ◽  
pp. 14670-14671 ◽  
Author(s):  
Kenichiro Itami ◽  
Toshiyuki Kamei ◽  
Jun-ichi Yoshida
Keyword(s):  
Diversity Oriented Synthesis ◽  
Tetrasubstituted Olefins

scholarly journals Diversity-Oriented Synthesis of 3-Iodochromones and Heteroatom Analogues via ICl-Induced Cyclization.

ChemInform ◽  
2006 ◽  
Vol 37 (27) ◽  
Author(s):  
Chengxiang Zhou ◽  
Anton V. Dubrovsky ◽  
Richard C. Larock
Keyword(s):  
Diversity Oriented Synthesis

scholarly journals A Modular Reaction Pairing Approach to the Diversity-Oriented Synthesis of Fused- and Bridged-Polycyclic Sultams

2011 ◽  
Vol 13 (19) ◽  
pp. 5148-5151 ◽  
Author(s):  
Thiwanka B. Samarakoon ◽  
Joanna K. Loh ◽  
Alan Rolfe ◽  
Lisa S. Le ◽  
Sun Young Yoon ◽  
...  
Keyword(s):  
Diversity Oriented Synthesis

ChemInform Abstract: Diversity-Oriented Synthesis of Hydrazine-Derived Compounds from Amino Isocyanates Generated in situ.

ChemInform ◽  
2014 ◽  
Vol 45 (18) ◽  
pp. no-no
Author(s):  
Christian Clavette ◽  
Jean-Francois Vincent Rocan ◽  
Andre M. Beauchemin
Keyword(s):  
Diversity Oriented Synthesis
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