scholarly journals Marching toward “heart work”: Connecting in new ways to thrive amidst COVID‐19 crisis

2021 ◽  
Author(s):  
Debarun Chakraborty ◽  
Wendrila Biswas ◽  
Ganesh Dash
Keyword(s):  
Heart Work

Living Well to Keep Your Pressure Down

EDIS ◽  
2017 ◽  
Vol 2017 (6) ◽  
Author(s):  
Linda B. Bobroff
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Health Problems ◽  
Fact Sheet ◽  
Living Well ◽  
Heart Work ◽  
Major Revision ◽  
Reduce Risk

High blood pressure, or hypertension, can cause serious health problems. It makes your heart work harder and can damage your blood vessels even if you feel okay. Everyone should have their blood pressure checked regularly. If you have certain risk factors, you are more likely to have high blood pressure. This 6-page fact sheet is a major revision that discusses risk factors and ways to reduce risk.

Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation

1999 ◽  
Vol 277 (4) ◽  
pp. E772-E777 ◽  
Author(s):  
Gary W. Goodwin ◽  
Heinrich Taegtmeyer
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Acetyl Coa Carboxylase ◽  
Physiological Conditions ◽  
Heart Work ◽  
Rat Hearts ◽  
Malonyl Coa ◽  
Work Transition ◽  
Endogenous Lipids

We tested the hypothesis that the level of malonyl-CoA, as well as the corresponding rate of total fatty acid oxidation of the heart, is regulated by the opposing actions of acetyl-CoA carboxylase (ACC) and malonyl-CoA decarboxylase (MCD). We used isolated working rat hearts perfused under physiological conditions. MCD in heart homogenates was measured specifically by14CO2production from [3-14C]malonyl-CoA, and ACC was measured specifically based on the portion of total carboxylase that is citrate sensitive. Increased heart work (1 μM epinephrine + 40% increase in afterload) elicited a 40% increase in total β-oxidation of exogenous plus endogenous lipids, accompanied by a 33% decrease in malonyl-CoA. The basal activity and citrate sensitivity of ACC (reflecting its phosphorylation state) and citrate content were unchanged. AMP levels were also unchanged. MCD activity, when measured at a subsaturating concentration of malonyl-CoA (50 μM), was increased by 55%. We conclude that physiological increments in AMP during the work transition are insufficient to promote ACC phosphorylation by AMP-stimulated protein kinase. Rather, increased fatty acid oxidation results from increased malonyl-CoA degradation by MCD.

Left heart work and temperature responses to cold exposure in man

1970 ◽  
Vol 26 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Donald F. Leon ◽  
Morteza Amidi ◽  
James J. Leonard
Keyword(s):  
Cold Exposure ◽  
Left Heart ◽  
Heart Work ◽  
Temperature Responses

Heart-Work: George Herbert and the Protestant Ethic (review)

1999 ◽  
Vol 23 (1-2) ◽  
pp. 108-111
Author(s):  
Michael Schoenfeldt
Keyword(s):  
Protestant Ethic ◽  
George Herbert ◽  
Heart Work

Myocardial anaerobic metabolism in intact dogs

1963 ◽  
Vol 204 (3) ◽  
pp. 427-432 ◽  
Author(s):  
William A. Neill ◽  
Norman Krasnow ◽  
Herbert J. Levine ◽  
Richard Gorlin
Keyword(s):  
Energy Source ◽  
Oxygen Consumption ◽  
Oxidative Metabolism ◽  
Anaerobic Metabolism ◽  
Muscle Metabolism ◽  
Mechanical Work ◽  
Work Output ◽  
Heart Work ◽  
Anaerobic Energy ◽  
The Difference

Energy liberated from substrates of heart muscle metabolism appears as mechanical work and heat. External mechanical work and heat production of the left ventricle were compared with its oxygen consumption in intact dogs. Under control conditions, within the range of accuracy possible, the sum of work and heat was equal to energy from oxidative metabolism. Intravascular administration of cyanide increased heart work but reduced its rate of aerobic metabolism. During the cyanide effect, work plus heat exceeded the energy available from oxidative metabolism. The difference represents myocardial anaerobic metabolism. Since the energy of mechanical work output alone was greater than the myocardial aerobic energy source, a portion of the anaerobic energy liberated must have been converted to mechanical work.

Sign in / Sign up

Export Citation Format

Share Document