Cantharidin‐Induced Skin Blister as an In Vivo Model of Inflammation

Janet Dawson; Melanie Vogelsanger

doi:10.1002/cpz1.49

Panel Discussion II: Usefulness of in vitro and in vivo Model Systems for Predicting the Adverse Public Health Outcome for Antimicrobial Drug Residues in Food

Microbial Ecology in Health and Disease ◽

10.1080/08910600050216174 ◽

2000 ◽

Vol 12 (3) ◽

pp. 45-53

Author(s):

Andrew Beaulieu ◽

Jacques Boisseau ◽

Carl Cerniglia ◽

Denis Corpet ◽

A. Haydée Fernández ◽

...

Keyword(s):

Public Health ◽

Health Outcome ◽

Panel Discussion ◽

Antimicrobial Drug ◽

Model Systems ◽

In Vivo Model ◽

Drug Residues ◽

Public Health Outcome

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P1735 Arginine supplementation and oxidative processes: in vivo model

European Heart Journal ◽

10.1016/s0195-668x(03)94873-1 ◽

2003 ◽

Vol 24 (5) ◽

pp. 330

Author(s):

A KOPFF

Keyword(s):

In Vivo Model ◽

Oxidative Processes ◽

Arginine Supplementation

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Establishment of an in vivo model for KCNJ5 dependent hyperaldosteronism

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0035-1547718 ◽

2015 ◽

Vol 122 (03) ◽

Cited By ~ 2

Author(s):

U Lichtenauer ◽

PL Schmid ◽

A Oßwald ◽

I Renner-Müller ◽

M Reincke ◽

...

Keyword(s):

In Vivo Model

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An in vivo Model for the Assessment of Acute Fibrinolytic Capacity of the Endothelium

Thrombosis and Haemostasis ◽

10.1055/s-0038-1657722 ◽

1997 ◽

Vol 78 (04) ◽

pp. 1242-1248 ◽

Cited By ~ 68

Author(s):

David E Newby ◽

Robert A Wright ◽

Christopher A Ludlam ◽

Keith A A Fox ◽

Nicholas A Boon ◽

...

Keyword(s):

Blood Flow ◽

Substance P ◽

Sodium Nitroprusside ◽

Plasma Concentrations ◽

In Vivo Model ◽

Forearm Circulation ◽

Von Willebrand ◽

Local Release ◽

Willebrand Factor

SummaryThe effects on blood flow and plasma fibrinolytic and coagulation parameters of intraarterial substance P, an endothelium dependent vasodilator, and sodium nitroprusside, a control endothelium independent vasodilator, were studied in the human forearm circulation. At subsystemic locally active doses, both substance P (2-8 pmol/min) and sodium nitroprusside (2-8 μg/min) caused dose-dependent vasodilatation (p <0.001 for both) without affecting plasma concentrations of PAI-1, von Willebrand factor antigen or factor VIII:C activity. Substance P caused local increases in t-PA antigen and activity (p <0.001) in the infused arm while sodium nitroprusside did not. At higher doses, substance P increased blood flow and t-PA concentrations in the noninfused arm. We conclude that brief, locally active and subsystemic infusions of intraarterial substance P cause a rapid and substantial local release of t-PA which appear to act via a flow and nitric oxide independent mechanism. This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely.

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