Immunohistochemical and Genetic Labeling of Hairy and Glabrous Skin Innervation

2021 ◽  
Vol 1 (5) ◽  
Author(s):  
Matthew B. Pomaville ◽  
Kevin M. Wright
Keyword(s):  
Glabrous Skin ◽  
Skin Innervation ◽  
Genetic Labeling

scholarly journals Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring

2021 ◽  
Vol Volume 14 ◽  
pp. 1573-1585
Author(s):  
Enriqueta Munoz-Islas ◽  
Cecilia Esther Elizondo-Martinez ◽  
Mariela Gutierrez-Lopez ◽  
Rosa Issel Acosta-Gonzalez ◽  
Veronica Zaga-Clavellina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Female Mouse ◽  
Glabrous Skin ◽  
Mechanical Sensitivity ◽  
Male And Female ◽  
Pain Behaviors ◽  
Skin Innervation

scholarly journals Dermoscopy revealing a case of Tinea Nigra*

2013 ◽  
Vol 88 (1) ◽  
pp. 128-129 ◽  
Author(s):  
Paulo Ricardo Criado ◽  
Lívia Delgado ◽  
Gustavo Alonso Pereira
Keyword(s):  
Infectious Diseases ◽  
Diagnostic Tool ◽  
Glabrous Skin ◽  
Daily Routine ◽  
Brown Patch ◽  
The Past ◽  
History Of ◽  
Tinea Nigra ◽  
Skin Conditions

Dermoscopy has being used over the past twenty years as a noninvasive aid in the diagnosis of innumerable skin conditions, including infectious diseases and infestations (Entodermoscopy).Tinea nigra is a superficial phaeohyfomycosis that affects mainly the glabrous skin of palms and soles. We describe a 14 year-old girl with a three-month history of an enlarging brown patch of her hand diagnosed as Tinea Nigra following clinical and dermoscopy examination.These images emphasize the importance of dermoscopy as a diagnostic tool in the daily routine of dermatologists.

Reconstruction of Large Palmar Defects of the Hand Using Free Flaps

1997 ◽  
Vol 22 (5) ◽  
pp. 623-630 ◽  
Author(s):  
M. M. NINKOVÍC ◽  
A. H. SCHWABEGGER ◽  
G. WECHSELBERGER ◽  
H. ANDERL
Keyword(s):  
Soft Tissue ◽  
Free Flap ◽  
Subcutaneous Tissue ◽  
Free Flaps ◽  
Difficult Problem ◽  
Glabrous Skin ◽  
Soft Tissue Reconstruction ◽  
Anatomical Structures ◽  
Tissue Reconstruction ◽  
Restoration Of Sensibility

The reconstruction of large palmar defects of the hand remains a difficult problem due to the specific anatomical structures and highly sophisticated function of the palm. The glabrous skin and subcutaneous tissue in the palm are perfectly adapted to serve the prehensile function. The particular aim must be that repairs to this functional structure are similar in texture and colour and are aesthetically acceptable. Restoration of sensibility is desirable. For smaller defects a great variety of local pedicled or island flaps can be applied. However, for larger defects with exposed tendons, nerves or other essential structures, free flaps remain as a reliable alternative. This paper reviews our approach of soft tissue reconstruction in 16 patients with large palmar defects using various kinds of free flaps. The advantages, disadvantages and current indications for free flap resurfacing of the palm are discussed.

Glabrous skin grafts for plantar defects

2001 ◽  
Vol 6 (4) ◽  
pp. 827-837 ◽  
Author(s):  
J.C Banis
Keyword(s):  
Glabrous Skin ◽  
Skin Grafts

scholarly journals Cocaine causes rapid remodeling of mesoaccumbens dopaminergic axons, synapses, and mitochondria

2021 ◽  
Author(s):  
Gregg Wildenberg ◽  
Anastasia Sorokina ◽  
Jessica Koranda ◽  
Alexis Monical ◽  
Chad Heer ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Large Scale ◽  
Drugs Of Abuse ◽  
Dopamine Neurons ◽  
Addictive Behaviors ◽  
Cell Type Specific ◽  
Genetic Labeling ◽  
Mitochondrial Elongation ◽  
First Time ◽  
Serial Electron Microscopy

Abstract Detailing the ways drugs of abuse physically alter dopaminergic circuits would provide new mechanisms for explaining addictive behaviors, future targets for therapeutic intervention, and insights into the nature of synaptic plasticity. We combine recent advances in genetic labeling with large volume serial electron microscopy to detail how normal dopaminergic (DA) axons interact with putative targets in the Nucleus Accumbens (NAc) and how those interactions change in mice briefly exposed to cocaine. We find that while most DA axonal boutons are devoid of obvious signs of synapses (i.e. synaptic vesicles or synaptic densities), many DA boutons physically interdigitate with dendrites or excitatory and inhibitory axons. A brief exposure to cocaine results in large-scale remodeling: extensive DA axonal branching and frequent occurrences of axonal blind-ended “bulbs”, filled with mitochondria and reminiscent of axonal retraction in the developing and damaged brain. The number of physical interdigitations and vesicle filled boutons in DA axons scales linearly with the length of axon in both controls and cocaine exposed animals and the size or the type of interaction (i.e. axo-axonic or axo-dendritic) do not change. Finally, we find in cocaine exposed animals, mitochondrial lengths are increased ~2.5 times relative to control. Mitochondrial elongation is cell type specific: primarily in DA neurons and downstream spiny dendrites, and localized to DA axons and not DA soma or dendrites. We show for the first time the effects of cocaine on remodeling of dopamine axon morphology and mitochondria and reveal new details on how dopamine neurons physically associate with downstream targets.

scholarly journals Specialized mechanoreceptor systems in rodent glabrous skin

2018 ◽  
Author(s):  
Jan Walcher ◽  
Julia Ojeda-Alonso ◽  
Julia Haseleu ◽  
Maria K. Oosthuizen ◽  
Ashlee H. Rowe ◽  
...  
Keyword(s):  
Small Group ◽  
Rodent Species ◽  
Glabrous Skin ◽  
Skin Area ◽  
Mechanical Stimuli ◽  
Orientation Sensitivity ◽  
Hairy Skin ◽  
Physiological Properties ◽  
Sensory Fibers ◽  
Very High

AbstractRodents use their forepaws to actively interact with their tactile environment. Studies on the physiology and anatomy of glabrous skin that makes up the majority of the forepaw are almost non-existent in the mouse. Here we developed a preparation to record from single sensory fibers of the forepaw and compared anatomical and physiological receptor properties to those of the hind paw glabrous and hairy skin. We found that the mouse forepaw skin is equipped with a very high density of mechanoreceptors; >3 fold more than hind paw glabrous skin. In addition, rapidly adapting mechanoreceptors that innervate Meissner’s corpuscles of the forepaw were several-fold more sensitive to slowly moving mechanical stimuli compared to their counterparts in the hind paw glabrous skin. All other mechanoreceptors types as well as myelinated nociceptors had physiological properties that were invariant regardless of which skin area they occupied. We discovered a novel D-hair receptor innervating a small group of hairs in the middle of the hind paw glabrous skin in mice. Glabrous D-hair receptors were direction sensitive albeit with an orientation sensitivity opposite to that described for hairy skin D-hair receptors. Glabrous D-hair receptors do not occur in all rodents, but are present in North American and African rodent species that diverged more than 65 million years ago. The function of these specialized hairs is unknown, but they are nevertheless evolutionarily very ancient. Our study reveals novel physiological specializations of mechanoreceptors in the glabrous skin that likely evolved to facilitate tactile exploration.

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