scholarly journals An Experimental Liver Metastasis Mouse Model Suitable for Short and Long‐Term Intravital Imaging

2021 ◽  
Vol 1 (5) ◽  
Author(s):  
Dieuwke L. Marvin ◽  
Peter ten Dijke ◽  
Laila Ritsma
Keyword(s):  
Liver Metastasis ◽  
Mouse Model ◽  
Intravital Imaging ◽  
Short And Long Term ◽  
Experimental Liver

scholarly journals Current Role of Surgery in Pancreatic Cancer With Synchronous Liver Metastasis

2020 ◽  
Vol 27 (1) ◽  
pp. 107327482097659
Author(s):  
Wentao Zhou ◽  
Dansong Wang ◽  
Wenhui Lou
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Synchronous Liver Metastasis ◽  
Long Term Outcomes ◽  
Short And Long Term ◽  
Current Guidelines

Pancreatic cancer with synchronous liver metastasis has an extremely poor prognosis, and surgery is not recommended for such patients by the current guidelines. However, an increasing body of studies have shown that concurrent resection of pancreatic cancer and liver metastasis is not only technically feasible but also beneficial to the survival in the selected patients. In this review, we aim to summarize the short- and long-term outcomes following synchronous liver metastasectomy for pancreatic cancer patients, and discuss the potential criteria in selecting appropriate surgical candidates, which might be helpful in clinical decision-making.

scholarly journals Radiofrequency ablation versus traditional liver resection and chemotherapy for liver metastases from gastric cancer

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052094050
Author(s):  
Kezhong Tang ◽  
Bo Zhang ◽  
Linping Dong ◽  
Lantian Wang ◽  
Zhe Tang
Keyword(s):  
Gastric Cancer ◽  
Radiofrequency Ablation ◽  
Liver Resection ◽  
Liver Metastasis ◽  
Liver Metastases ◽  
Statistical Significance ◽  
Local Treatment ◽  
Long Term Outcomes ◽  
Short And Long Term

Objective To compare the short- and long-term outcomes of radiofrequency ablation (RFA) versus liver resection and chemotherapy for liver metastases from gastric cancer. Methods We retrospectively evaluated 50 patients who underwent curative gastrectomy and local treatments for liver metastases (RFA, n = 20; liver resection, n = 20; and chemotherapy, n = 10) from 2008 to 2018. Results The short- and long-term outcomes of each local treatment were evaluated. The median overall survival (OS) after RFA was similar to that after liver resection (20 vs. 20 months, respectively) and longer than that after chemotherapy (20 vs. 10 months, respectively). The 3-year OS and progression-free survival (PFS) rates after RFA were 20% and 10%, respectively, while those in the liver resection group were 23.5% and 23.5%, respectively. The 3-year OS rate after chemotherapy was 10%. The size and number of metastases were prognostic factors for patients with gastric cancer with liver metastasis without statistical significance. Conclusions Among patients with liver metastasis from gastric cancer, OS and PFS were satisfactory and comparable between RFA and liver resection but better than those of chemotherapy. RFA is an appropriate option for patients with gastric cancer who have a solitary liver metastasis measuring ≤3.0 cm.

Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome

Neuroscience ◽  
2016 ◽  
Vol 333 ◽  
pp. 277-301 ◽  
Author(s):  
Fiorenza Stagni ◽  
Andrea Giacomini ◽  
Marco Emili ◽  
Stefania Trazzi ◽  
Sandra Guidi ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Long Term Effects ◽  
Ts65dn Mouse ◽  
Short And Long Term ◽  
Hippocampal Development

scholarly journals Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis

2021 ◽  
Author(s):  
Julia Sehl‐Ewert ◽  
Theresa Schwaiger ◽  
Alexander Schäfer ◽  
Julia E. Hölper ◽  
Barbara G. Klupp ◽  
...  
Keyword(s):  
Mouse Model ◽  
Herpes Virus ◽  
Human Herpes ◽  
Virus Encephalitis ◽  
Human Herpes Virus ◽  
Short And Long Term ◽  
Herpès Virus

Short- and Long-term Histological Changes in Liver Parenchyma After Different Resection Methods and Their Potential Role in Treatment of Colorectal Liver Metastasis

2020 ◽  
Vol 40 (3) ◽  
pp. 1359-1365
Author(s):  
ANDRÁS PALKOVICS ◽  
ANDRÁS VERECZKEI ◽  
ANDRÁS FINCSUR ◽  
ISTVÁN KISS ◽  
BALÁZS NÉMETH ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Potential Role ◽  
Liver Parenchyma ◽  
Histological Changes ◽  
Short And Long Term

Simultaneous Laparoscopic Resection of Colorectal Cancer and Synchronous Metastatic Liver Tumor

2011 ◽  
Vol 96 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Michihiro Hayashi ◽  
Koji Komeda ◽  
Yoshihiro Inoue ◽  
Tetsunosuke Shimizu ◽  
Mitsuhiro Asakuma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Laparoscopic Resection ◽  
Surgical Margin ◽  
Skin Incision ◽  
Long Term Results ◽  
Synchronous Liver Metastasis ◽  
Short And Long Term ◽  
Operation Duration

Abstract Laparoscopic colorectal resection has been applied to advanced colorectal cancer. Synchronous liver metastasis of colorectal cancer would be treated safely and effectively by simultaneous laparoscopic colorectal and hepatic resection. Seven patients with colorectal cancer and synchronous liver metastasis treated by simultaneous laparoscopic resection were analyzed retrospectively. Three patients received a hybrid operation using a small skin incision, 2 patients underwent hand-assisted laparoscopic surgery using a small incision produced for colonic anastomosis, and 2 patients were treated with pure laparoscopic resection. The mean total operation duration was 407 minutes, and mean blood loss was 207 mL. Negative surgical margins were achieved in all cases. Mean postoperative hospital stay was 16.4 days. No recurrence at the surgical margin was observed in the liver. For selected patients with synchronous liver metastasis of colorectal cancer, simultaneous laparoscopic resection is useful for minimizing operative invasiveness while maintaining safety and curability, with satisfying short- and long-term results.

scholarly journals Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

2016 ◽  
Vol 130 ◽  
pp. 118-128 ◽  
Author(s):  
Jessica H. Hall ◽  
Frances K. Wiseman ◽  
Elizabeth M.C. Fisher ◽  
Victor L.J. Tybulewicz ◽  
John L. Harwood ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Mouse Model ◽  
Trisomy 21 ◽  
Short And Long Term
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