Effect of nicotine and vasopressin on the terminal vascular bed of the heart

1968 ◽  
Vol 9 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Karel Rakusan ◽  
Wolfgang du Mesnil de Rochemont ◽  
Jon Hanlon ◽  
Wolfgang Braasch ◽  
Hans Tschopp ◽  
...  
Keyword(s):  
Vascular Bed ◽  
Terminal Vascular Bed

scholarly journals Pressure measurements in the terminal vascular bed of the epimyocardium of rats and cats.

1981 ◽  
Vol 49 (5) ◽  
pp. 1202-1211 ◽  
Author(s):  
H Tillmanns ◽  
M Steinhausen ◽  
H Leinberger ◽  
H Thederan ◽  
W Kübler
Keyword(s):  
Pressure Measurements ◽  
Vascular Bed ◽  
Terminal Vascular Bed

The fine structure of gingival terminal vascular bed

1973 ◽  
Vol 6 (2) ◽  
pp. 137-152 ◽  
Author(s):  
A.H. Mohamed ◽  
J.P. Waterhouse ◽  
H.H.R. Friederici
Keyword(s):  
Fine Structure ◽  
Vascular Bed ◽  
Terminal Vascular Bed

The influence of smoking on the functional state of microcirculation according to laser doppler flowmetry and clinical anamnestic data of patients with arterial hypertension

2021 ◽  
Vol 24 (4) ◽  
pp. 24-31
Author(s):  
N. N. Streltsova ◽  
A. P. Vasiliev
Keyword(s):  
Blood Flow ◽  
Arterial Hypertension ◽  
Functional State ◽  
Laser Doppler Flowmetry ◽  
Tobacco Smoke ◽  
Tobacco Smoking ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Vascular Bed ◽  
Terminal Vascular Bed

Background. Detailed study of the functional state of microcirculation in combination of arterial hypertension and tobacco smoking, as the most common and prognostically important risk factors for atherogenesis, will not only clarify pathogenetic effect of tobacco smoke on the terminal vascular bed, but also outline directions of active counteraction to it.Purpose. To study the effect of TS on the functional state of SM using laser Doppler flowmetry in patients with AH.Methods. 185 patients with stage 1,2 AH involved in the study were divided into 2 equivalent groups according to main clinical and laboratory data: group 1 – non-smokers (n = 134, mean age was 57.0 [50.0; 60.0]), group 2 – patients who smoke 1–1.5 packs of cigarettes per day (n = 51, mean age was 54.0 [48.0; 58.0]). Patients were prescribed short-acting antihypertensives drugs, which were used whenever required 5 days before the study. SM was investigated by laser Doppler flowmetry using occlusion test and amplitude-frequency spectrum analysis of hemoperfusion fluctuations.Results. Obtained data showed negative acute effect of ingredients of tobacco smoke on almost all structural elements of microhemocirculation. Revealed deviations are characterized by constriction of precapillary segment of microvascular bed with increase in myogenic tone and equal 3.1 units [2.6; 4.1] versus 2.3 units [1.7; 3.4] in the alternative group (p = 0.007), decrease in capillary blood flow from 4.5 units [3.5; 5.8] compared with the group of non-smokers – 5.2 units [4.0; 7.3] (p = 0.041), statistically significant intensification of arteriolar-venular blood flow with formation of venous congestion, limitation of dilated reserve of microcirculation.Conclusion. Tobacco smoking leads to significant microcirculation disorders that are projected onto changes in terminal vascular bed, inherent with AH, which significantly reduces the functional state of microcirculation, limits its reserve potential and promotes the development of tissue ischemia.

Effect of Nicotine and Vasopressin on Capillary Blood Flow and Capacity of the Terminal Vascular Bed

Pharmacology ◽  
1967 ◽  
Vol 17 (2) ◽  
pp. 119-128
Author(s):  
K. Rakusan ◽  
W. Du Mesnil De Rochemont ◽  
J. Hanlon ◽  
W. Braasch ◽  
H. Tschopp ◽  
...  
Keyword(s):  
Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Vascular Bed ◽  
Terminal Vascular Bed

Pharmacologic properties of antihistamines in relation to vascular reactivity

1965 ◽  
Vol 209 (3) ◽  
pp. 550-556 ◽  
Author(s):  
Burton M. Altura ◽  
Benjamin W. Zweifach
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Local Anesthetic ◽  
Vascular Reactivity ◽  
Blocking Agent ◽  
Vascular Bed ◽  
Adrenergic Blockers ◽  
Insight Into ◽  
Anesthetic Mechanisms ◽  
Terminal Vascular Bed

Experiments were designed to gain further insight into the vasoconstrictor action of antihistamines and to assess further the validity of using antihistamine constrictor action to implicate the presence of "intrinsic" histamine in the terminal vascular bed of normal animals. Experiments with adrenergic blockers eliminate endogenous epinephrine as the sole mechanism responsible for the observed vasoconstriction with antihistamines. Furthermore, experiments with antiserotonin compounds indicate that the constriction cannot be attributed to endogenous 5-HT. In addition, experiments with a cholinergic blocking agent as well as with a local anesthetic eliminate cholinergic or local anesthetic mechanisms as being responsible for the observed antihistamine constriction. The local action of antihistamines likewise clearly rules out a central nervous system pathway which might operate in animals given antihistamines systemically. Experiments with bilateral adrenalectomized animals reveal heightened antihistamine constrictor action which is greatly exacerbated when these animals are given Dibenzyline. These findings are discussed in relation to recent work with antihistamines on ion transport. The present study questions the use of antihistamine constrictor action, to validate the presence and contribution of intrinsic histamine in microcirculatory regulation of normal animals.

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