Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions

2017 ◽  
Vol 103 (5) ◽  
pp. 758-760 ◽  
Author(s):  
Maciej J. Zamek-Gliszczynski ◽  
Kathleen M. Giacomini ◽  
Lei Zhang
Keyword(s):  
Drug Interactions ◽  
Organic Cation ◽  
Clinical Importance ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 1 ◽  
Drug Pharmacokinetics

scholarly journals Drug-Drug Interactions at Organic Cation Transporter 1

2021 ◽  
Vol 12 ◽  
Author(s):  
Shiwei Zhou ◽  
Sujuan Zeng ◽  
Yan Shu
Keyword(s):  
Drug Interactions ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Vital Role ◽  
Organic Cations ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Organic Cation Transporter 1 ◽  
Solute Carrier ◽  
Endogenous Substances ◽  
Interaction Between Drugs

The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays a vital role in the membrane transport of organic cations including endogenous substances and xenobiotics. This article mainly discusses the drug-drug interactions (DDIs) mediated by OCT1 and their clinical significance.

scholarly journals Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions

2016 ◽  
Vol 7 ◽  
Author(s):  
Cristina Arimany-Nardi ◽  
Gerard Minuesa ◽  
Thorsten Keller ◽  
Itziar Erkizia ◽  
Hermann Koepsell ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 1

L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides

2016 ◽  
Vol 68 (9) ◽  
pp. 1160-1169 ◽  
Author(s):  
Azusa Futatsugi ◽  
Yusuke Masuo ◽  
Shiori Kawabata ◽  
Noritaka Nakamichi ◽  
Yukio Kato
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 1

scholarly journals The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC-1 coactivator

2016 ◽  
Vol 173 (10) ◽  
pp. 1703-1715 ◽  
Author(s):  
Lucie Hyrsova ◽  
Tomas Smutny ◽  
Alejandro Carazo ◽  
Stefan Moravcik ◽  
Jana Mandikova ◽  
...  
Keyword(s):  
Organic Cation ◽  
Pregnane X Receptor ◽  
Organic Cation Transporter ◽  
Human Hepatocytes ◽  
Organic Cation Transporter 1

PIII-66Development of an immobilized human organic cation transporter 1 column for use in on-line screening

2006 ◽  
Vol 79 (2) ◽  
pp. P76-P76
Author(s):  
F BIGHI ◽  
R YAMAGUCHI ◽  
S PATEL ◽  
P HO ◽  
I WAINER ◽  
...  
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
On Line ◽  
Organic Cation Transporter 1

scholarly journals Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1

2021 ◽  
Vol 11 ◽  
Author(s):  
Giuliano Ciarimboli
Keyword(s):  
Organic Cation ◽  
Basolateral Membrane ◽  
Organic Cation Transporter ◽  
Organic Cations ◽  
Regulatory Processes ◽  
Organic Cation Transporter 1 ◽  
Exogenous Origin ◽  
And Function

The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane. In humans, OCT1 is mainly expressed in the sinusoidal membrane of hepatocytes, while in rodents, OCT1 is strongly represented also in the basolateral membrane of renal proximal tubule cells. Considering that organic cations of endogenous origin are important neurotransmitters and that those of exogenous origin are important drugs, these transporters have significant physiological and pharmacological implications. Because of the high expression of OCTs in excretory organs, their activity has the potential to significantly impact not only local but also systemic concentration of their substrates. Even though many aspects governing OCT function, interaction with substrates, and pharmacological role have been extensively investigated, less is known about regulation of OCTs. Possible mechanisms of regulation include genetic and epigenetic modifications, rapid regulation processes induced by kinases, regulation caused by protein–protein interaction, and long-term regulation induced by specific metabolic and pathological situations. In this mini-review, the known regulatory processes of OCT1 expression and function obtained from in vitro and in vivo studies are summarized. Further research should be addressed to integrate this knowledge to known aspects of OCT1 physiology and pharmacology.

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