Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

HM Jones; Y Chen; C Gibson; T Heimbach; N Parrott; SA Peters; J Snoeys; VV Upreti; M Zheng; SD Hall

doi:10.1002/cpt.37

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.37 ◽

2015 ◽

Vol 97 (3) ◽

pp. 247-262 ◽

Cited By ~ 235

Author(s):

HM Jones ◽

Y Chen ◽

C Gibson ◽

T Heimbach ◽

N Parrott ◽

...

Keyword(s):

Drug Discovery ◽

Pharmaceutical Industry ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Drug Discovery And Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development

CPT Pharmacometrics & Systems Pharmacology ◽

10.1038/psp.2013.41 ◽

2013 ◽

Vol 2 (8) ◽

pp. 63 ◽

Cited By ~ 182

Author(s):

HM Jones ◽

K Rowland-Yeo

Keyword(s):

Drug Discovery ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Drug Discovery And Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Basic Concepts

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Development and Application of Physiologically Based Pharmacokinetic-Modeling Tools to Support Drug Discovery

Chemistry & Biodiversity ◽

10.1002/cbdv.200590119 ◽

2005 ◽

Vol 2 (11) ◽

pp. 1462-1486 ◽

Cited By ~ 32

Author(s):

Christian Lüpfert ◽

Andreas Reichel

Keyword(s):

Drug Discovery ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Tools ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Predicting Human Pharmacokinetics: Physiologically Based Pharmacokinetic Modeling and In Silico ADME Prediction in Early Drug Discovery

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-018-0503-9 ◽

2018 ◽

Vol 44 (1) ◽

pp. 135-137 ◽

Cited By ~ 2

Author(s):

Jian Shi ◽

Weibin Zha

Keyword(s):

Drug Discovery ◽

In Silico ◽

Pharmacokinetic Modeling ◽

Human Pharmacokinetics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Adme Prediction ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Silico Adme Prediction ◽

Early Drug

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Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2125 ◽

2020 ◽

Author(s):

Tycho Heimbach ◽

Yuan Chen ◽

Jun Chen ◽

Vaishali Dixit ◽

Neil Parrott ◽

...

Keyword(s):

Pharmaceutical Industry ◽

Hepatic Impairment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Exposure During Pregnancy

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Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of fluoxetine and norfluoxetine pharmacokinetic profiles using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1927 ◽

2021 ◽

Author(s):

Hyeon‐Cheol Jeong ◽

Yoon‐Jee Chae ◽

Sooyeun Lee ◽

Wonku Kang ◽

Hwi‐yeol Yun ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Pharmacokinetic Profiles ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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