scholarly journals Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein‐Mediated Drug‐Drug Interactions in Healthy Volunteers

2020 ◽  
Author(s):  
Takeshi Miyake ◽  
Emi Kimoto ◽  
Lina Luo ◽  
Sumathy Mathialagan ◽  
Lauren M. Horlbogen ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Drug Interactions ◽  
Healthy Volunteers ◽  
Toxin Extrusion

scholarly journals Arsenic-Related Health Risk Assessment of Realgar-Containing NiuHuangJieDu Tablets in Healthy Volunteers Po Administration

2022 ◽  
Vol 12 ◽  
Author(s):  
Xiao Wu ◽  
Ruoning Yan ◽  
Rong Guan ◽  
Yi Du ◽  
Yuexin Liu ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Healthy Volunteers ◽  
Arsenic Speciation ◽  
Arsenic Exposure ◽  
Hydride Generation ◽  
Atomic Fluorescence Spectrometry ◽  
Total Arsenic ◽  
Atomic Fluorescence

Realgar, an arsenic-containing traditional Chinese medicine of As2S2, has significant therapeutic effects for hundreds of years. NiuHuangJieDu tablets (NHJDT) is one of the most commonly prescribed realgar-containing preparations for the treatment of sore throat, swelling, and aching of gums. However, realgar-containing TCMs raise great safety concerns due to the adverse effects reported by arsenic poisoning. In this study, the arsenic-related health risk assessment of NHJDT was conducted in healthy volunteers after single and multiple doses oral administration. Blood, plasma, and urine samples were collected after dosing at predetermined time points or periods. Simple, rapid, and sensitive methods were established for the quantification of total arsenic and arsenic speciation in biological samples. The total arsenic and arsenic speciation were determined by hydride generation-atomic fluorescence spectrometry (HG-AFS) and high-performance liquid chromatography–hydride generation–atomic fluorescence spectrometry (HPLC-HG-AFS), respectively. No significant fluctuation of total arsenic was observed in human blood, and no traces of arsenic speciation were found in human plasma. Dimethylarsenic acid was detected as the predominated arsenic species in human urine after dosing. Therapeutic dose administration of NHJDT was relatively safe in single dose for the limited blood arsenic exposure, but long-term medication may still pose health risks due to the accumulation of arsenics in blood and its extremely slow excretion rate. Therefore, arsenic exposure should be carefully monitored during realgar-containing TCM medication, especially for long-term regimen. The results obtained in this study will provide scientific references for the clinical application of realgar and its-containing TCMs.

Drug-Drug Interactions Between Raltegravir and Pravastatin in Healthy Volunteers

2010 ◽  
Vol 55 (1) ◽  
pp. 82-86 ◽  
Author(s):  
Matthijs van Luin ◽  
Angela Colbers ◽  
Eleonora W J van Ewijk-Beneken Kolmer ◽  
Corrien P W G M Verweij-van Wissen ◽  
Bas Schouwenberg ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Healthy Volunteers

Drug interactions evaluation: An integrated part of risk assessment of therapeutics

2010 ◽  
Vol 243 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Lei Zhang ◽  
Kellie S. Reynolds ◽  
Ping Zhao ◽  
Shiew-Mei Huang
Keyword(s):  
Risk Assessment ◽  
Drug Interactions

scholarly journals 45 Drug-drug interactions between ivacaftor and midazolam or rosiglitazone in healthy volunteers

2012 ◽  
Vol 11 ◽  
pp. S67
Author(s):  
Y. Chen ◽  
J. Huang ◽  
C.L. Ordonez ◽  
J. Zhang ◽  
L. Mahnke ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Healthy Volunteers

scholarly journals Evaluation of Pharmacokinetic Drug Interactions Between Gemigliptin (Dipeptidylpeptidase-4 Inhibitor) and Glimepiride (Sulfonylurea) in Healthy Volunteers

Drugs in R&D ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. 165-176 ◽  
Author(s):  
Hee Youn Choi ◽  
Yo Han Kim ◽  
Mi Jo Kim ◽  
Shi Hyang Lee ◽  
Keunsu Bang ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Healthy Volunteers ◽  
Dipeptidylpeptidase 4 ◽  
Pharmacokinetic Drug

Evaluating the safety, tolerability, pharmacokinetics, and drug interactions of elsulfavirine in healthy volunteers and patients with liver disorders

2020 ◽  
Vol 18 (2) ◽  
pp. 40-46
Author(s):  
A.V. Kravchenko ◽  
◽  
R.Yu. Arsienko ◽  
V.N. Azarova ◽  
A.V. Pokrovskaya ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Drug Interactions ◽  
Healthy Volunteers ◽  
Key Words ◽  
Liver Disorders ◽  
Class A

Key words: elsulfavirine, pharmacokinetics, class A and B liver cirrhosis, rifampicin, rifabutin

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