scholarly journals Opportunities for Quantitative Translational Modeling in Oncology

2020 ◽  
Vol 108 (3) ◽  
pp. 447-457 ◽  
Author(s):  
James W.T. Yates ◽  
Helen Byrne ◽  
Sonya C. Chapman ◽  
Tao Chen ◽  
Lourdes Cucurull‐Sanchez ◽  
...  
Keyword(s):  
Translational Modeling

scholarly journals Translational modeling of non-traumatic raised intracranial pressure in rodents; the impact of diet-induced obesity on cephalic hypersensitivity and retinal degeneration

2021 ◽  
Author(s):  
Connar Stanley James Westgate ◽  
Snorre Malm Hagen ◽  
Ida Marchen Egerod Israelsen ◽  
Steffen Ellitsgaard Hamann ◽  
Rigmor Jensen ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Control Diet ◽  
Disease Model ◽  
Fiber Layer ◽  
Diet Induced Obesity ◽  
The Impact ◽  
First Time ◽  
Novel Model ◽  
Icp Recording ◽  
Translational Modeling

Elevated intracranial pressure (ICP) is a feature of critical cerebral disorders. Obesity has been linked to raised ICP, and especially to disorders such as idiopathic intracranial pressure (IIH). We aimed to explore the impact of diet-induced obesity (DIO) on ICP, cephalic sensitivity and structural retinal changes with the dual goal of developing a disease model for non-traumatic raised ICP and IIH. Rats were fed high-fat diet or matched control diet. To assess pain sensitivity, Von Frey and light/dark box testing were performed. Dual energy x-ray absorptiometry scanning was used to measure body composition. Optic nerve head and retinal structures were evaluated using optical coherence tomography. Intraocular pressure was assessed. Rats were then implanted with telemetric device for continuous ICP recording. At the end, eye histology and molecular analysis on choroid plexus (CP) and trigeminal ganglion (TG) were performed. The DIO rats had double the abdominal fat mass. ICP was 55% higher in obese rats (p=0.003). Altered pain thresholds were found in DIO rats as denoted by a lower periorbital threshold (p=0.0002). Expression of Calca and Trpv1 was elevated in TG. Furthermore, a peripapillary retinal nerve fiber layer swelling (p=0.0026) with subsequent neuroretinal degeneration p=0.02) was detected in DIO rats. There was a trend to increased expression of AQP1 and NKCC1 at CP. This study demonstrates for the first time that DIO leads to raised ICP, with clinically relevant sequalae. Our novel model for non-traumatic raised ICP could expand the knowledge regarding disorders with elevated ICP and IIH.

scholarly journals New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response

2017 ◽  
Vol 10 (5) ◽  
pp. 366-379 ◽  
Author(s):  
IH Bartelink ◽  
N Zhang ◽  
RJ Keizer ◽  
N Strydom ◽  
PJ Converse ◽  
...  
Keyword(s):  
Treatment Response ◽  
Tuberculosis Treatment ◽  
New Paradigm ◽  
Translational Modeling

scholarly journals Vocalization development in common marmosets for neurodegenerative translational modeling

2018 ◽  
Vol 40 (4) ◽  
pp. 303-311 ◽  
Author(s):  
Corinne A. Jones ◽  
Mary K. Duffy ◽  
Sarah A. Hoffman ◽  
Nancy J. Schultz-Darken ◽  
Katarina M. Braun ◽  
...  
Keyword(s):  
Common Marmosets ◽  
Translational Modeling

scholarly journals In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5583
Author(s):  
Guilherme Ribeiro Romualdo ◽  
Kaat Leroy ◽  
Cícero Júlio Silva Costa ◽  
Gabriel Bacil Prata ◽  
Bart Vanderborght ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
In Vitro Models ◽  
Virus Infections ◽  
Alcoholic Fatty Liver ◽  
Contaminated Food ◽  
Patient Prognosis ◽  
Key Events ◽  
Translational Modeling

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin-contaminated food, and non-alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti-HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of-the-art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.

Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

2020 ◽  
Vol 37 (6) ◽  
Author(s):  
Sandra Suarez-Sharp ◽  
Anders Lindahl ◽  
Tycho Heimbach ◽  
Amin Rostami-Hodjegan ◽  
Michael B. Bolger ◽  
...  
Keyword(s):  
Drug Products ◽  
Translational Modeling
Sign in / Sign up

Export Citation Format

Share Document