Gram‐Scale Preparation of C‐Terminal‐Modified Enkephalin Analogues by Typical Liquid‐Phase Peptide Synthesis

2019 ◽  
Vol 98 (1) ◽  
Author(s):  
Yeon Sun Lee
Keyword(s):  
Liquid Phase ◽  
Peptide Synthesis ◽  
Enkephalin Analogues ◽  
Scale Preparation

Synthetic hydroxymethyl-porphyrins for protection of carboxy group

2007 ◽  
Vol 11 (06) ◽  
pp. 434-441 ◽  
Author(s):  
Hitoshi Tamiaki ◽  
Kouji Kumon ◽  
Reiko Shibata
Keyword(s):  
Liquid Phase ◽  
Carboxylic Acid ◽  
Thin Layer ◽  
Peptide Synthesis ◽  
Phenyl Group ◽  
Coupling Reagents ◽  
Protective Groups ◽  
Simple Filtration ◽  
Meso Position ◽  
Layer Chromatography

Hydroxymethyl-porphyrins were prepared by modifying tetraarylporphyrin possessing a p-(methoxycarbonyl)phenyl group at the meso-position and octaethylporphyrin. The synthetic alcohols reacted with carboxylic acids by the use of coupling reagents, to give the corresponding esters quantitatively. Due to the porphyrin dye moiety, the esterification was easily monitored on thin layer chromatography, and the resulting esters were highly soluble in most organic solvents and easily handled. The esters were readily cleaved by the action of an acid to give the original carboxylic acid and hydroxymethyl-porphyrin. Separation of the two species was performed by simple filtration: the carboxylic acid was soluble (filtrate) and the porphyrins were precipitates in methanol. These protective groups for carboxy groups were useful for peptide synthesis in the liquid phase.

New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis

1980 ◽  
Vol 45 (26) ◽  
pp. 5364-5370 ◽  
Author(s):  
V. N. Rajasekharan Pillai ◽  
Manfred Mutter ◽  
Ernst Bayer ◽  
Ian Gatfield
Keyword(s):  
Liquid Phase ◽  
Ethylene Glycol ◽  
Peptide Synthesis ◽  
Phase Method ◽  
Poly Ethylene Glycol ◽  
Liquid Phase Method ◽  
Poly Ethylene

scholarly journals Front Cover: Photo-Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag-Assisted Liquid-Phase Peptide Synthesis (Asian J. Org. Chem. 11/2017)

2017 ◽  
Vol 6 (11) ◽  
pp. 1505-1505
Author(s):  
Hiroki Wakamatsu ◽  
Yohei Okada ◽  
Masae Sugai ◽  
Syed R. Hussaini ◽  
Kazuhiro Chiba
Keyword(s):  
Liquid Phase ◽  
Benzyl Alcohol ◽  
Peptide Synthesis ◽  
Front Cover

Photo-Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag-Assisted Liquid-Phase Peptide Synthesis

2017 ◽  
Vol 6 (11) ◽  
pp. 1584-1588 ◽  
Author(s):  
Hiroki Wakamatsu ◽  
Yohei Okada ◽  
Masae Sugai ◽  
Syed R. Hussaini ◽  
Kazuhiro Chiba
Keyword(s):  
Liquid Phase ◽  
Benzyl Alcohol ◽  
Peptide Synthesis

scholarly journals Front Cover: Hydrophobic Magnetic Nanoparticle Assisted One-Pot Liquid-Phase Peptide Synthesis (Eur. J. Org. Chem. 40/2017)

2017 ◽  
Vol 2017 (40) ◽  
pp. 5942-5942
Author(s):  
Yohei Okada ◽  
Hitomi Asama ◽  
Hiroki Wakamatsu ◽  
Kazuhiro Chiba ◽  
Hidehiro Kamiya
Keyword(s):  
Liquid Phase ◽  
Peptide Synthesis ◽  
Magnetic Nanoparticle ◽  
One Pot ◽  
Front Cover
Sign in / Sign up

Export Citation Format

Share Document