Doxorubicin‐Conjugated Iron Oxide Nanoparticles: Surface Engineering and Biomedical Investigation

ChemPlusChem ◽  
2020 ◽  
Vol 85 (6) ◽  
pp. 1156-1163
Author(s):  
Viktoriia Oleksa ◽  
Hana Macková ◽  
Vitalii Patsula ◽  
Aneta Dydowiczová ◽  
Olga Janoušková ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Oxide Nanoparticles ◽  
Biomedical Investigation

The effect of superparamagnetic iron oxide nanoparticles surface engineering on relaxivity of magnetoliposome

2016 ◽  
Vol 11 (5) ◽  
pp. 340-349 ◽  
Author(s):  
Sepideh Khaleghi ◽  
Fatemeh Rahbarizadeh ◽  
Davoud Ahmadvand ◽  
Mahrooz Malek ◽  
Hamid Reza Madaah Hosseini
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Surface engineering of magnetic iron oxide nanoparticles by polymer grafting: synthesis progress and biomedical applications

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14957-14975 ◽  
Author(s):  
Zaiyan Hou ◽  
Yijing Liu ◽  
Jiangping Xu ◽  
Jintao Zhu
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Surface Grafting ◽  
Oxide Nanoparticles ◽  
Polymer Grafting ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

Current strategies for surface grafting polymers on magnetic iron oxide nanoparticles and their biomedical applications are summarized in this review.

scholarly journals Toxicity Assessment of Silica Coated Iron Oxide Nanoparticles and Biocompatibility Improvement by Surface Engineering

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85835 ◽  
Author(s):  
Maria Ada Malvindi ◽  
Valeria De Matteis ◽  
Antonio Galeone ◽  
Virgilio Brunetti ◽  
George C. Anyfantis ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Toxicity Assessment ◽  
Oxide Nanoparticles

scholarly journals Surface engineering of iron oxide nanoparticles for cancer therapy

2017 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
KC Barick ◽  
PA Hassan ◽  
SantoshL Gawali ◽  
Bijaideep Dutta
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Oxide Nanoparticles

scholarly journals Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

2021 ◽  
Vol 12 ◽  
pp. 270-281
Author(s):  
Barbora Svitkova ◽  
Vlasta Zavisova ◽  
Veronika Nemethova ◽  
Martina Koneracka ◽  
Miroslava Kretova ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Surface Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Surface Engineering ◽  
Imaging Techniques ◽  
A549 Cells ◽  
Mechanistic Study ◽  
Target Cells ◽  
Oxide Nanoparticles ◽  
The Impact

The efficient entry of nanotechnology-based pharmaceuticals into target cells is highly desired to reach high therapeutic efficiency while minimizing the side effects. Despite intensive research, the impact of the surface coating on the mechanism of nanoparticle uptake is not sufficiently understood yet. Herein, we present a mechanistic study of cellular internalization pathways of two magnetic iron oxide nanoparticles (MNPs) differing in surface chemistry into A549 cells. The MNP uptake was investigated in the presence of different inhibitors of endocytosis and monitored by spectroscopic and imaging techniques. The results revealed that the route of MNP entry into cells strongly depends on the surface chemistry of the MNPs. While serum bovine albumin-coated MNPs entered the cells via clathrin-mediated endocytosis (CME), caveolin-mediated endocytosis (CavME) or lipid rafts were preferentially involved in the internalization of polyethylene glycol-coated MNPs. Our data indicate that surface engineering can contribute to an enhanced delivery efficiency of nanoparticles.

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