Electrophysiology of the gastric musculature

2011 ◽  
Author(s):  
Kenton M. Sanders ◽  
Nelson G. Publicover
Keyword(s):  
Gastric Musculature

scholarly journals Histological, biochemical and pharmacologycal characterization of the gastric muscular layer in Chagas disease

2011 ◽  
Vol 26 (suppl 2) ◽  
pp. 74-78 ◽  
Author(s):  
Wagner Carlucci ◽  
Reginaldo Ceneviva ◽  
Sérgio Henrique Ferreira ◽  
Orlando Castro de Silva
Keyword(s):  
Anterior Part ◽  
Acetylcholinesterase Activity ◽  
Muscle Layer ◽  
Cholinergic Innervation ◽  
Control Group ◽  
Cholinergic Drugs ◽  
Gastric Musculature ◽  
And Control

PURPOSE: To assess in vitro the correlation between the number of neurons and the sensitivity to cholinergic drugs and acetylcholinesterase activity in chagasic patients. METHODS: A 3x1 cm strip of the muscle layer of the anterior part of the stomach, always close to the angular incisure, was removed from 10 chronic chagasic patients (6 men) submitted to megaesophagus or megacolon surgery and from 10 non-chagasic patients (4 men) submitted to other types of surgery (control group), aged on average 52.3 and 50.1 years, respectively, for histological and pharmacological studies. The action of cholinergic drugs was investigated in isolated preparations according to the superfusion method of Ferreira and Costa, and acetylcholinesterase activity was determined by the method of Ellman. For neuron count, the strips were cut into 8 µm sections according to the method standardized by Alcântara. RESULTS: There was a difference in number of neurons between the chagasic (5,6) and control (7,3) groups. Acetylcholinesterase activity, in moles of hydrolyzed substrate per minute per gram tissue, was reduced in chagasic patients (4,32) compared to the controls (7,30). No hypersensitivity of the gastric musculature to cholinergic drugs was detected, with a reduced maximum response to carbachol and betanechol in the chagasic group. CONCLUSIONS: The reduction of neurons in the myenteric plexus of the stomach of chronic chagasic patients can be demonstrated even in the absence of clinical chagasic gastropathy. The hypersensitivity of the gastric musculature to cholinergic drugs probably depends on intense denervation. The reduced acetylcholinesterase activity demonstrates the involvement of the cholinergic innervation in the stomach of chronic chagasic patients. There was no correlation between number of neurons, sensitivity to cholinergic drugs and acetylcholinesterase activity in the gastric musculature of chagasic and non-chagasic patients.

scholarly journals Biomagnetic signatures of uncoupled gastric musculature

2009 ◽  
Vol 21 (7) ◽  
pp. 778-e50 ◽  
Author(s):  
l. a. bradshaw ◽  
a. irimia ◽  
j. a. sims ◽  
w. o. richards
Keyword(s):  
Gastric Musculature

scholarly journals Rupture of the Stomach in the Newborn Due to Congenital Defects in the Gastric Musculature

1956 ◽  
Vol 31 (155) ◽  
pp. 56-58 ◽  
Author(s):  
P. C. MacGillivray ◽  
A. M. Stewart ◽  
A. MacFarlane
Keyword(s):  
Congenital Defects ◽  
Gastric Musculature

scholarly journals Reaction to drugs of strips of the rabbit's gastric musculature

1926 ◽  
Vol 61 (2) ◽  
pp. 261-267 ◽  
Author(s):  
G. L. Brown ◽  
B. A. McSwiney
Keyword(s):  
Gastric Musculature

Gastric dysmotility in Duchenne muscular dystrophy: Distribution of dystrophin and utrophin in gastric musculature

2016 ◽  
Vol 26 ◽  
pp. S120-S121
Author(s):  
C. Fuller ◽  
B. Wong ◽  
K. Shellenbarger ◽  
J. Reuss ◽  
C. Hackett ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Gastric Musculature

On the shortening of the lesser curvature of the stomachs with chronic peptic ulcer—from the viewpoint of anatomy of the gastric musculature

1968 ◽  
Vol 3 (4) ◽  
pp. 267-268
Author(s):  
K. Yoshida ◽  
K. Yoshikawa ◽  
N. Fujimaki ◽  
Y. Aoki ◽  
M. Uchida
Keyword(s):  
Peptic Ulcer ◽  
Gastric Musculature ◽  
Lesser Curvature

Vagotomy confined to the acid-secreting mucosa of the stomach

1987 ◽  
Vol 73 (1) ◽  
pp. 25-30
Author(s):  
E. P. Dewar ◽  
N. S. Williams ◽  
M. F. Dixon ◽  
D. Johnston
Keyword(s):  
Gastric Secretion ◽  
Myenteric Plexus ◽  
Acid Output ◽  
Gastric Wall ◽  
Neural Tissue ◽  
Gastric Fistula ◽  
Gastric Acid Output ◽  
Before And After ◽  
Acid Secreting ◽  
Gastric Musculature

AbstractChemoneurolysis, using varying concentrations of ethyl alcohol, was performed in dogs with a total gastric fistula in an attempt to denervate selectively only the acid-secreting mucosa, leaving the muscle innervated. Tests of gastric secretion and histological examination of gastric wall biopsies were performed both before and after chemoneurolysis. Chemoneurolysis resulted in a significant reduction in the number of parasympathetic fibres in the submucosa (p<0.01) and a decrease in insulin and pentagastrin stimulated acid secretion. The appearances of the myenteric plexus and gastric musculature were unchanged. The destruction of the submucosal neural tissue was, however, insufficient to produce a th erapeutically significant decrease in gastric acid output.

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