The metabolism of isolated fat cells

2011 ◽  
Author(s):  
Martin Rodbell
Keyword(s):  
Fat Cells ◽  
Isolated Fat Cells

scholarly journals Insulin-Receptor Interaction in Isolated Fat Cells

1969 ◽  
Vol 244 (19) ◽  
pp. 5181-5188
Author(s):  
T. Minemura ◽  
Oscar B. Crofford
Keyword(s):  
Insulin Receptor ◽  
Receptor Interaction ◽  
Fat Cells ◽  
Isolated Fat Cells

A procedure for measurement of distribution spaces in isolated fat cells

1972 ◽  
Vol 286 (1) ◽  
pp. 1-9 ◽  
Author(s):  
J. Gliemann ◽  
K. Østerlind ◽  
J. Vinten ◽  
S. Gammeltoft
Keyword(s):  
Fat Cells ◽  
Isolated Fat Cells ◽  
Distribution Spaces

scholarly journals Factors affecting the permeability of isolated fat-cells from the rat to [42K]potassium and [36Cl]chloride ions

1970 ◽  
Vol 117 (3) ◽  
pp. 615-621 ◽  
Author(s):  
M. C. Perry ◽  
C. N. Hales
Keyword(s):  
Initial Phase ◽  
Chloride Ions ◽  
Fat Cells ◽  
Adrenocorticotrophic Hormone ◽  
Isolated Fat Cells ◽  
Free Medium ◽  
Fat Cell ◽  
Factors Affecting ◽  
Exchange Diffusion ◽  
High K

1. The effluxes of 42K+ and 36Cl− from isolated fat-cells from the rat were studied under a variety of conditions known to affect the metabolism of the cells. 2. 42K+ efflux from isolated fat cells was increased in a Na+-free–high-K+ medium and decreased in a K+-free medium. The existence of K+ exchange diffusion across the fat-cell membrane is suggested. 3. 36Cl− efflux from isolated fat-cells was decreased when the Cl− component of the wash medium was replaced by acetate. The basal 36Cl− efflux is suggested to be partly by Cl− exchange diffusion and partly in company with a univalent cation. 4. A variety of lipolytic stimuli, adrenaline, adrenocorticotrophic hormone, N-6,O-2′-dibutyryladenosine cyclic 3′:5′-monophosphate and theophylline, increased 42K+ efflux from isolated fat-cells. The adrenaline stimulation was biphasic; an initial, rapid and transient increase in 42K+ loss from the fat-cells was followed by a slower, more prolonged, increase in 42K+ efflux. The initial phase was inhibited by phentolamine but not by propranolol. 5. Insulin increased 42K+ efflux only after preincubation with the cells.

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