scholarly journals Epigenetics of Aberrant Cardiac Wound Healing

2018 ◽  
pp. 451-491 ◽  
Author(s):  
Adam Russell-Hallinan ◽  
Chris J. Watson ◽  
John A. Baugh
Keyword(s):  
Wound Healing ◽  
Cardiac Wound Healing

Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice

2001 ◽  
Vol 173 (1) ◽  
pp. 75-82 ◽  
Author(s):  
W. M. Blankesteijn ◽  
E. Creemers ◽  
E. Lutgens ◽  
J. P. M. Cleutjens ◽  
M. J. A. P. Daemen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
Cardiac Wound Healing

scholarly journals Cortical Bone Derived Stem Cells for Cardiac Wound Healing

2019 ◽  
Vol 49 (4) ◽  
pp. 314 ◽  
Author(s):  
Sadia Mohsin ◽  
Steven R. Houser
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Cortical Bone ◽  
Cardiac Wound Healing

PET Imaging of Cardiac Wound Healing Using a Novel [68Ga]-Labeled NGR Probe in Rat Myocardial Infarction

2014 ◽  
Vol 17 (1) ◽  
pp. 76-86 ◽  
Author(s):  
Jochen Tillmanns ◽  
Magdalena Schneider ◽  
Daniela Fraccarollo ◽  
Jan-Dieter Schmitto ◽  
Florian Länger ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
Pet Imaging ◽  
Cardiac Wound Healing

scholarly journals Periodontal-induced chronic inflammation triggers macrophage secretion of Ccl12 to inhibit fibroblast-mediated cardiac wound healing

JCI Insight ◽  
2017 ◽  
Vol 2 (18) ◽  
Author(s):  
Kristine Y. DeLeon-Pennell ◽  
Rugmani Padmanabhan Iyer ◽  
Osasere K. Ero ◽  
Courtney A. Cates ◽  
Elizabeth R. Flynn ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Inflammation ◽  
Cardiac Wound Healing

scholarly journals CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming

Circulation ◽  
2017 ◽  
Vol 136 (3) ◽  
pp. 297-313 ◽  
Author(s):  
Nadine Borg ◽  
Christina Alter ◽  
Nicole Görldt ◽  
Christoph Jacoby ◽  
Zhaoping Ding ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
T Cells ◽  
Metabolic Reprogramming ◽  
Cardiac Wound Healing

scholarly journals Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction

2018 ◽  
Vol 314 (2) ◽  
pp. H224-H235 ◽  
Author(s):  
Cesar A. Meschiari ◽  
Mira Jung ◽  
Rugmani Padmanabhan Iyer ◽  
Andriy Yabluchanskiy ◽  
Hiroe Toba ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
Growth Factor ◽  
Matrix Metalloproteinase ◽  
Transforming Growth Factor ◽  
Left Ventricular ◽  
Matrix Metalloproteinase 9 ◽  
Sequencing Analysis ◽  
Metalloproteinase 9 ◽  
Cardiac Wound Healing

Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after myocardial infarction (MI). Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages show better outcomes post-MI, whereas aged TG mice show a worse aging phenotype, we wanted to evaluate the effect of aging superimposed on MI to see if the detrimental effect of aging counteracted the benefits of macrophage MMP-9 overexpression. We used 17- to 28-mo-old male and female C57BL/6J wild-type (WT) and TG mice ( n = 10–21 mice/group) to evaluate the effects of aging superimposed on MI. Despite similar infarct areas and mortality rates at day 7 post-MI, aging TG mice showed improved diastolic properties and remodeling index compared with WT mice (both P < 0.05). Macrophage numbers were higher in TG than WT mice at days 0 and 7 post-MI, and the post-MI increase was due to elevated cluster of differentiation 18 protein levels (all P < 0.05). RNA sequencing analysis of cardiac macrophages isolated from day 7 post-MI infarcts identified 1,276 statistically different (all P < 0.05) genes (994 increased and 282 decreased in TG mice). Reduced expression of vascular endothelial growth factor A, platelet-derived growth factor subunit A, and transforming growth factor-β3, along with elevated expression of tissue inhibitor of MMP-4, in macrophages revealed mechanisms of indirect downstream effects on fibroblasts and neovascularization. While collagen accumulation was enhanced in TG mice compared with WT mice at days 0 and 7 post-MI ( P < 0.05 for both), the post-MI collagen cross-linking ratio was higher in WT mice ( P < 0.05), consistent with increased diastolic volumes. Vessel numbers [by Griffonia ( Bandeiraea) simplicifolia lectin I staining] were decreased in TG mice compared with WT mice at days 0 and 7 post-MI ( P < 0.05 for both). In conclusion, macrophage-derived MMP-9 improved post-MI cardiac wound healing through direct and indirect mechanisms to improve diastolic physiology and remodeling.NEW & NOTEWORTHY Aging mice with macrophage overexpression of matrix metalloproteinase-9 have increased macrophage numbers 7 days after myocardial infarction, resulting in improved diastolic physiology and left ventricular remodeling through effects on cardiac wound healing.

scholarly journals Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Mark A. Evans ◽  
Nicola Smart ◽  
Karina N. Dubé ◽  
Sveva Bollini ◽  
James E. Clark ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Cell ◽  
Inflammatory Cell Infiltration ◽  
Cell Infiltration ◽  
Thymosin Β4 ◽  
Cardiac Wound Healing
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