Regulation of Cerebral Blood Flow: Response to Cytochrome P450 Lipid Metabolites

2018 ◽  
pp. 801-821 ◽  
Author(s):  
David R. Harder ◽  
Kevin R. Rarick ◽  
Debebe Gebremedhin ◽  
Susan S. Cohen
Keyword(s):  
Blood Flow ◽  
Cytochrome P450 ◽  
Cerebral Blood Flow ◽  
Blood Flow Response ◽  
Flow Response ◽  
Lipid Metabolites

Effect of caffeine on theophyliine on cerebral blood flow response to brain activation: In vitro and in vivo studies

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S198-S198
Author(s):  
Joseph R Meno ◽  
Thien-son K Nguyen ◽  
Elise M Jensen ◽  
G Alexander West ◽  
Leonid Groysman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Activation ◽  
In Vivo Studies ◽  
Blood Flow Response ◽  
Flow Response

scholarly journals Hypoxia and Hypotension Transform the Blood Flow Response to Cortical Spreading Depression from Hyperemia into Hypoperfusion in the Rat

2008 ◽  
Vol 28 (7) ◽  
pp. 1369-1376 ◽  
Author(s):  
Inna Sukhotinsky ◽  
Ergin Dilekoz ◽  
Michael A Moskowitz ◽  
Cenk Ayata
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cortical Spreading Depression ◽  
Spreading Depression ◽  
Ischemic Penumbra ◽  
Doppler Flowmetry ◽  
Blood Flow Response ◽  
Flow Response ◽  
Normal Rat ◽  
Cortex Cérébral

Cortical spreading depression (CSD) evokes a large cerebral blood flow (CBF) increase in normal rat brain. In contrast, in focal ischemic penumbra, CSD-like periinfarct depolarizations (PID) are mainly associated with hypoperfusion. Because PIDs electrophysiologically closely resemble CSD, we tested whether conditions present in ischemic penumbra, such as tissue hypoxia or reduced perfusion pressure, transform the CSD-induced CBF response in nonischemic rat cortex. Cerebral blood flow changes were recorded using laser Doppler flowmetry in rats subjected to hypoxia, hypotension, or both. Under normoxic normotensive conditions, CSD caused a characteristic transient CBF increase (74 ± 7%) occasionally preceded by a small hypoperfusion (−4 ± 2%). Both hypoxia ( pO2 45 ± 3 mm Hg) and hypotension (blood pressure 42 ± 2 mm Hg) independently augmented this initial hypoperfusion (−14 ± 2% normoxic hypotension; −16 ± 6% hypoxic normotension; −21 ± 5% hypoxic hypotension) and diminished the magnitude of hyperemia (44 ± 10% normoxic hypotension; 43 ± 9% hypoxic normotension; 27 ± 6% hypoxic hypotension). Hypotension and, to a much lesser extent, hypoxia increased the duration of hypoperfusion and the DC shift, whereas CSD amplitude remained unchanged. These results suggest that hypoxia and/or hypotension unmask a vasoconstrictive response during CSD in the rat such that, under nonphysiologic conditions (i.e., mimicking ischemic penumbra), the hyperemic response to CSD becomes attenuated resembling the blood flow response during PIDs.

Regional heterogeneity of cerebral blood flow response to graded volume-controlled hemorrhage

1996 ◽  
Vol 22 (10) ◽  
pp. 1026-1033 ◽  
Author(s):  
K. F. Waschke ◽  
M. Riedel ◽  
D. M. Albrecht ◽  
K. van Ackern ◽  
W. Kuschinsky
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Heterogeneity ◽  
Blood Flow Response ◽  
Flow Response ◽  
Volume Controlled

scholarly journals Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke

2019 ◽  
Vol 266 (4) ◽  
pp. 990-997 ◽  
Author(s):  
Clara Gregori-Pla ◽  
Igor Blanco ◽  
Pol Camps-Renom ◽  
Peyman Zirak ◽  
Isabel Serra ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Blood Flow Response ◽  
Bed Elevation ◽  
Flow Response ◽  
Head Of Bed Elevation

P3-311: Baseline lipid levels predict cerebral blood flow response to statin therapy in middle-aged adults at risk for Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P671-P672
Author(s):  
Cynthia Carlsson ◽  
Benjamin Austin ◽  
Barbara Bendlin ◽  
Hanna Blazel ◽  
Jodi Barnet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
At Risk ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Statin Therapy ◽  
Lipid Levels ◽  
Middle Aged ◽  
Blood Flow Response ◽  
Flow Response ◽  
Middle Aged Adults

Diminished regional cerebral blood flow response to vibration in patients with blepharospasm

Neurology ◽  
1999 ◽  
Vol 52 (2) ◽  
pp. 291-291 ◽  
Author(s):  
R. J. Feiwell ◽  
K. J. Black ◽  
L. A. McGee-Minnich ◽  
A. Z. Snyder ◽  
A.-M. MacLeod ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Blood Flow Response ◽  
Flow Response
Sign in / Sign up

Export Citation Format

Share Document