The Diversity of Linear Conjugated Polyenes and Colours in Nature: Raman Spectroscopy as a Diagnostic Tool

ChemPhysChem ◽  
2020 ◽  
Author(s):  
Lenize F. Maia ◽  
Vanessa E. De Oliveira ◽  
Howell G. M. Edwards ◽  
Luiz Fernando C. De Oliveira
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool ◽  
Conjugated Polyenes

Rapid diagnostics of liver steatosis by Raman spectroscopyviafiber optic probe: a pilot study

The Analyst ◽  
2018 ◽  
Vol 143 (19) ◽  
pp. 4723-4731 ◽  
Author(s):  
Marta Z. Pacia ◽  
Krzysztof Czamara ◽  
Magdalena Zebala ◽  
Edyta Kus ◽  
Stefan Chlopicki ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Pilot Study ◽  
Diagnostic Tool ◽  
Fiber Optic ◽  
Liver Steatosis ◽  
Rapid Diagnostics ◽  
Fiber Optic Probes ◽  
Optic Probe ◽  
Rapid Quantification

Raman spectroscopyviafiber optic probes enables assessment of the liver condition and rapid quantification of liver steatosis, thus, this technique has the potential as a diagnostic tool.

Raman spectroscopy as a diagnostic tool for monitoring acute nephritis

2015 ◽  
Vol 9 (3) ◽  
pp. 260-269 ◽  
Author(s):  
Jingting Li ◽  
Yong Du ◽  
Ji Qi ◽  
Ravikumar Sneha ◽  
Anthony Chang ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool

O78. Parameters defining the potential applicability of raman spectroscopy as a diagnostic tool for oral disease

2009 ◽  
Vol 3 (1) ◽  
pp. 82
Author(s):  
K. Guze ◽  
M. Short ◽  
S. Sonis ◽  
N. Karimbux ◽  
J. Chan ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool ◽  
Oral Disease ◽  
Potential Applicability

Raman Spectroscopy Applied to Parathyroid Tissues: A New Diagnostic Tool to Discriminate Normal Tissue from Adenoma

2017 ◽  
Vol 90 (1) ◽  
pp. 847-854 ◽  
Author(s):  
Andrea Palermo ◽  
Marco Fosca ◽  
Gaia Tabacco ◽  
Federico Marini ◽  
Valerio Graziani ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool ◽  
Normal Tissue

Raman spectroscopy as a tool in differentiating conjugated polyenes from synthetic and natural sources

2015 ◽  
Vol 134 ◽  
pp. 434-441 ◽  
Author(s):  
Rafaella F. Fernandes ◽  
Lenize F. Maia ◽  
Mara R.C. Couri ◽  
Luiz Antonio S. Costa ◽  
Luiz Fernando C. de Oliveira
Keyword(s):  
Raman Spectroscopy ◽  
Natural Sources ◽  
Conjugated Polyenes

scholarly journals Raman Spectroscopy Provides a Powerful Diagnostic Tool for Accurate Determination of Albumin Glycation

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32406 ◽  
Author(s):  
Narahara Chari Dingari ◽  
Gary L. Horowitz ◽  
Jeon Woong Kang ◽  
Ramachandra R. Dasari ◽  
Ishan Barman
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool ◽  
Accurate Determination ◽  
Powerful Diagnostic Tool

Raman spectroscopy: a diagnostic tool for detection of early malignant changes in the larynx

2000 ◽  
Author(s):  
Nicholas Stone ◽  
Pelagia Stavroulaki ◽  
Catherine A. Kendall ◽  
Martin Birchall ◽  
Hugh Barr
Keyword(s):  
Raman Spectroscopy ◽  
Diagnostic Tool ◽  
Malignant Changes

Raman spectroscopy as a potential diagnostic tool to analyse biochemical alterations in lung cancer

The Analyst ◽  
2020 ◽  
Vol 145 (2) ◽  
pp. 385-392 ◽  
Author(s):  
Qingfeng Zheng ◽  
Junyi Li ◽  
Lin Yang ◽  
Bo Zheng ◽  
Jiangcai Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Raman Spectroscopy ◽  
Cancer Progression ◽  
Diagnostic Tool ◽  
Molecular Level ◽  
Rapid Diagnosis ◽  
Clinical Practices ◽  
Biochemical Alterations ◽  
Diagnosis Tool

Raman spectroscopy can be used as a rapid diagnosis tool in lung cancer to help us understand cancer progression at molecular level and improve clinical practices.

scholarly journals Raman spectroscopy of monosodium urate crystals: A novel tool for non-invasive gout diagnosis

2021 ◽  
Author(s):  
Faizan Bilwani
Keyword(s):  
Raman Spectroscopy ◽  
Sensitivity And Specificity ◽  
Diagnostic Tool ◽  
False Positives ◽  
Monosodium Urate ◽  
Monosodium Urate Crystals ◽  
Detection Techniques ◽  
Non Invasive ◽  
Msu Crystals ◽  
Urate Crystals

Gout is the most common form of inflammatory arthritis. It results in the deposition of monosodium urate crystals (MSU) at the surface of a joint or the articular cartilage. The gold standard for gout diagnosis is synovial fluid (SF) analysis which requires aspiration of the fluid and subsequent analysis by polarized light microscopy (PLM). This has poor reproducibility, is invasive and requires trained personal to perform the analysis. Raman spectroscopy (RS) has the potential to be a non-invasive diagnostic tool that can detect the presence of MSU crystals. The purpose of the research was to determine whether Raman spectroscopy applied onto the surface of a joint could detect MSU crystals through the skin. Two clinical studies were conducted, entitled the Pilot study (Pilot) and the sons of gout study (SOG). Pilot (n=20) considered ten clinically diagnosed gout sufferers and ten clinically diagnosed Osteoarthritis (OA) patients that acted as control. SOG (n=25) considered nine asymptomatic patients where gout was confirmed by clinicians at time of experiment by ultrasound, and 16 Non-Gouty patients, which did not show any signs of gout. An algorithm was implemented in Matlab® 2016 that removed background florescence, performed denoising and identified the presence or absence of MSU peaks. The comparisons were made against Raman peaks that are known to relate to MSU according to the literature. Three peak combinations, entitled C1, C2 and C3 were evaluated based on their resulting sensitivities and specificities for both studies. C1 was chosen as it provided the highest sensitivity for both studies. Pilot was found to have a sensitivity and specificity of 0.8 and 0.7, respectively. SOG had a sensitivity and specificity of 1 and 0.5, respectively. The results indicated that RS diagnosis is able to achieve good to high sensitivity comparable to other gout detection techniques but a moderate to good specificity. The results also show that RS is fully capable of detecting MSU crystals in-vivo, but results in a high number of false positives, 2 for Pilot and 7 for SOG. However, the false positives in Pilot may be attributed to the control subjects suffering from osteoarthritis, which can be a precursor of gout, and the false positives in the SOG study may be a result of ultrasound (US) being used as the confirmatory diagnostic technique that RS is being compared to. US is known to have sensitivity as low as 0.22 and is operator-dependent. Larger population studies are needed to confirm the ability of RS as a diagnostic tool for detecting gout.

Sign in / Sign up

Export Citation Format

Share Document