Novel approaches on bulk‐loading of large scale spatial datasets

2021 ◽  
Author(s):  
Mustafa Utku Kalay
Keyword(s):  
Large Scale ◽  
Bulk Loading ◽  
Spatial Datasets ◽  
Novel Approaches

scholarly journals Novel Approaches for BAV Aortopathy Prediction—Is There a Need for Cohort Studies and Biomarkers?

Biomolecules ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 58 ◽  
Author(s):  
Evaldas Girdauskas ◽  
Johannes Petersen ◽  
Niklas Neumann ◽  
Shiho Naito ◽  
Tatiana Gross ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Large Scale ◽  
Point Of View ◽  
Rna Molecules ◽  
Improve Risk Stratification ◽  
Non Coding Rna ◽  
Life Threatening ◽  
Novel Biomarkers ◽  
Novel Approaches ◽  
Biomarker Research

Bicuspid aortic valve (BAV) disease is the most common congenital malformation of the human heart with a prevalence of 1–2% in the general population. More than half of patients with a BAV present with a dilated proximal aorta (so-called bicuspid aortopathy) which is associated with an enhanced risk of life-threatening aortic complications. Up to now, the pathogenesis of bicuspid aortopathy as well as the risk stratification of aortic complications has not yet been sufficiently clarified. Recent findings have shown that bicuspid aortopathy features phenotypic heterogeneity. Two distinct valvulo-aortic phenotypes, the so-called root phenotype, as well as a dilation of the tubular ascending aorta, coincide with a significantly different risk for aortal complications. However, the phenotype-based classification that is only based on these two clinical forms is not sufficient to estimate the risk of aortal complications in a prognostically relevant way. Therefore, there is growing clinical interest to assess novel approaches in BAV research and to introduce circulating biomarkers as an elegant diagnostic tool to improve risk stratification in BAV aortopathy. A large scale epidemiological cohort study, ranking from apparently healthy individuals to disease patients, and comprehensive biobanks provide the opportunity to study BAV disease and its complications and to identify novel biomarkers for BAV aortopathy surveillance and prognosis. Firstly, the data indicate that several protein-based biomarkers and non-coding RNA molecules, in particular circulating microRNAs, can serve as relevant molecular biomarkers to predict the course of BAV-associated aortopathy. Here, we review the current literature and knowledge about BAV from a clinical point of view, and report about novel approaches in BAV biomarker research.

scholarly journals Sudden Cardiac Death and Arrhythmias

2018 ◽  
Vol 7 (2) ◽  
pp. 111 ◽  
Author(s):  
Neil T Srinivasan ◽  
Richard J Schilling ◽  
◽  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Large Scale ◽  
Public Health Problem ◽  
Screening Tools ◽  
Poor Survival ◽  
Novel Approaches ◽  
Traditional Risk Factors ◽  
Artery Disease ◽  
Large Scale Screening

Sudden cardiac death (SCD) and arrhythmia represent a major worldwide public health problem, accounting for 15–20 % of all deaths. Early resuscitation and defibrillation remains the key to survival, yet its implementation and the access to public defibrillators remains poor, resulting in overall poor survival to patients discharged from hospital. Novel approaches employing smart technology may provide the solution to this dilemma. Though the majority of cases are attributable to coronary artery disease, a thorough search for an underlying cause in cases where the diagnosis is unclear is necessary. This enables better management of arrhythmia recurrence and screening of family members. The majority of cases of SCD occur in patients who do not have traditional risk factors for arrhythmia. New and improved large scale screening tools are required to better predict risk in the wider population who represent the majority of cases of SCD.

Molecular tools for studies on the transmission biology ofEchinococcus multilocularis

Parasitology ◽  
2003 ◽  
Vol 127 (S1) ◽  
pp. S53-S61 ◽  
Author(s):  
P. DEPLAZES ◽  
A. DINKEL ◽  
A. MATHIS
Keyword(s):  
Environmental Samples ◽  
Large Scale ◽  
Diagnostic Method ◽  
Epidemiological Studies ◽  
Liver Lesions ◽  
Molecular Tools ◽  
Faecal Samples ◽  
Novel Approaches ◽  
Transmission Biology

Two novel approaches for diagnosis of intestinalEchinococcus multilocularisinfection, the detection ofE. multilocularis-specific coproantigens in ELISA and of copro-DNA by PCR, have been successfully implemented. These methods have proven their value for thepost mortemand theintra vitamdiagnosis ofE. multilocularisin definitive hosts. They have also made novel approaches possible to study the transmission biology of the parasite as they allow detection of the infection in faecal samples collected in the environment. Coproantigen detection is the diagnostic method of choice as it is sensitive, fast and cheap. Studies on faecal samples collected in the field revealed that coproantigen detection did reflect the different prevalences in fox populations as assessed from foxes at necropsy and also the effect of deworming efforts in foxes as achieved by long-term distribution of praziquantel-containing baits. The use of PCR for routine diagnostic or large-scale purposes is hampered by the fact that DNA extraction from faecal material is a very laborious task. Therefore, PCR is rationally used for confirmatory purposes of copro-antigen-positive samples. As taeniid eggs cannot further be differentiated morphologically, PCR is the method of choice to identifyE. multilocularisinfections in faecal or environmental samples containing taeniid eggs. In intermediate rodent hosts, PCR is routinely used in epidemiological studies for identifyingE. multilocularisfrom liver lesions which are often very small, atypical or calcified.

scholarly journals COVID-19 and cardiovascular comorbidity: novel approaches to reduce mortality

2021 ◽  
Vol 20 (4) ◽  
pp. 2953
Author(s):  
S. S. Bunova ◽  
P. I. Okhotnikova ◽  
Yu. P. Skirdenko ◽  
N. A. Nikolaev ◽  
O. A. Osipova ◽  
...  
Keyword(s):  
Large Scale ◽  
Mutual Influence ◽  
Inpatient Mortality ◽  
Long Term Effects ◽  
Cardiovascular Comorbidity ◽  
Novel Approaches ◽  
The Impact ◽  
Cvd Mortality

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and significantly affect patient quality of life and socioeconomic status. Numerous reports consistently demonstrate that CVDs are a major risk factor for severe course of coronavirus disease 2019 (COVID-19), including higher risks of hospitalizations and inpatient mortality. In the context of the current pandemic, managing patients with CVDs requires special attention from doctors. There are now more and more reports of the long-term effects of COVID-19. The long-term effects on cardiovascular system of millions of COVID-19 survivors are currently unknown. The aim of the review was to systematize the accumulated knowledge about the mutual influence of COVID-19 and CVDs. The features of CVD impact on the course and outcomes of COVID-19, as well as the reasons for the worsening of CVD course in patients with COVID-19 are considered. The impact of redistribution of health care resources and large-scale isolation measures on the management of patients with CVDs is discussed. The review also presents the most relevant data on long COVID. Predictors of a long-term disease course were identified for risk stratification in order to timely implement preventive measures and develop an individualized treatment. The authors focused on finding novel approaches to reduce CVD mortality during a pandemic.

scholarly journals Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Le Li ◽  
Zhao Hu ◽  
Yulong Xiong ◽  
Yan Yao
Keyword(s):  
Cardiovascular Diseases ◽  
Sympathetic Nerve ◽  
Large Scale ◽  
Clinical Evidence ◽  
Ventricular Remodeling ◽  
Therapeutic Option ◽  
Vascular Endothelial ◽  
Randomized Controlled ◽  
Novel Approaches ◽  
Nerve Regulation

Sympathetic overactivation plays an important role in promoting a variety of pathophysiological processes in cardiovascular diseases (CVDs), including ventricular remodeling, vascular endothelial injury and atherosclerotic plaque progression. Device-based sympathetic nerve (SN) regulation offers a new therapeutic option for some CVDs. Renal denervation (RDN) is the most well-documented method of device-based SN regulation in clinical studies, and several large-scale randomized controlled trials have confirmed its value in patients with resistant hypertension, and some studies have also found RDN to be effective in the control of heart failure and arrhythmias. Pulmonary artery denervation (PADN) has been clinically shown to be effective in controlling pulmonary hypertension. Hepatic artery denervation (HADN) and splenic artery denervation (SADN) are relatively novel approaches that hold promise for a role in cardiovascular metabolic and inflammatory-immune related diseases, and their first-in-man studies are ongoing. In addition, baroreflex activation, spinal cord stimulation and other device-based therapies also show favorable outcomes. This review summarizes the pathophysiological rationale and the latest clinical evidence for device-based therapies for some CVDs.

Some comments about observations and image processing of comet 29P/Schwassmann-Wachmann 1

1999 ◽  
Vol 173 ◽  
pp. 243-248
Author(s):  
D. Kubáček ◽  
A. Galád ◽  
A. Pravda
Keyword(s):  
Image Processing ◽  
Large Scale ◽  
Harvard College ◽  
Oak Ridge ◽  
Large Scale Structures ◽  
Short Period Comet ◽  
Short Period ◽  
Scale Structures ◽  
Harvard College Observatory ◽  
Period Comet

AbstractUnusual short-period comet 29P/Schwassmann-Wachmann 1 inspired many observers to explain its unpredictable outbursts. In this paper large scale structures and features from the inner part of the coma in time periods around outbursts are studied. CCD images were taken at Whipple Observatory, Mt. Hopkins, in 1989 and at Astronomical Observatory, Modra, from 1995 to 1998. Photographic plates of the comet were taken at Harvard College Observatory, Oak Ridge, from 1974 to 1982. The latter were digitized at first to apply the same techniques of image processing for optimizing the visibility of features in the coma during outbursts. Outbursts and coma structures show various shapes.

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