scholarly journals Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers

2021 ◽  
Author(s):  
Xiaoshu Dai ◽  
Michael D. Karol ◽  
Matthew Hitron ◽  
Marjie L. Hard ◽  
Matthew T. Goulet ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Interaction Potential ◽  
Healthy Adult ◽  
Oral Dosing ◽  
Potential Safety ◽  
Drug Drug Interaction ◽  
Adult Volunteers

scholarly journals Comparison of the Drug-Drug Interaction Potential of Daptomycin in Combination with Rifampin in Healthy Adult Volunteers

2018 ◽  
Vol 62 (12) ◽  
Author(s):  
Russell J. Benefield ◽  
E. Susan Slechta ◽  
Christopher M. Gast ◽  
Emily S. Spivak ◽  
Kimberly E. Hanson ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Single Nucleotide Polymorphisms ◽  
Interaction Potential ◽  
Half Life ◽  
Healthy Adult ◽  
Volume Of Distribution ◽  
Healthy Adults ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Adult Volunteers

ABSTRACT We evaluated the effects of rifampin coadministration and MDR1 single nucleotide polymorphisms on the disposition of daptomycin in twelve healthy adults. There were no significant changes from baseline in the clearance (0.53 versus 0.55 liters/h, P = 1.00), volume of distribution (7.0 versus 7.2 liter, P = 0.62), or half-life (9.7 versus 9.6 h, P = 0.89) of daptomycin after exposure to rifampin. The tested MDR1 polymorphisms were not associated with significant differences in daptomycin disposition.

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