A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX‐02 in Healthy Subjects

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.914 ◽

2021 ◽

Author(s):

Andi Leubitz ◽

Frederic Vanhoutte ◽

Ming‐yi Hu ◽

Kaela Porter ◽

Efrat Gordon ◽

...

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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Erratum: A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

Molecular Psychiatry ◽

10.1038/mp.2016.140 ◽

2016 ◽

Vol 21 (10) ◽

pp. 1483-1484 ◽

Cited By ~ 5

Author(s):

M Fava ◽

K Johe ◽

L Ereshefsky ◽

L G Gertsik ◽

B A English ◽

...

Keyword(s):

Dose Escalation ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Depressed Patients ◽

Phase 1B

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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly selective Na v 1.8 inhibitor, in healthy adults

Clinical and Translational Science ◽

10.1111/cts.13215 ◽

2021 ◽

Author(s):

Hemme J. Hijma ◽

Emilie M. J. Brummelen ◽

Pieter S. Siebenga ◽

Geert Jan Groeneveld

Keyword(s):

Phase I ◽

Dose Escalation ◽

Multiple Dose ◽

Healthy Adults ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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A randomized, double-blind, multiple-dose, placebo-controlled, dose escalation study with a 3-cohort parallel group design to investigate the tolerability and pharmacokinetics of albaconazole in healthy subjects

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.72 ◽

2013 ◽

Vol 3 (1) ◽

pp. 25-33 ◽

Cited By ~ 3

Author(s):

Albert J. Dietz ◽

Joanna C. Barnard ◽

Koen van Rossem

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Group Design ◽

Parallel Group Design ◽

Parallel Group

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Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cpp46273 ◽

2008 ◽

Vol 46 (06) ◽

pp. 273-279 ◽

Cited By ~ 25

Author(s):

S. Irie ◽

Y. Matsumura ◽

M. Zdravkovic ◽

L.V. Jacobsen ◽

S. Kageyama

Keyword(s):

Dose Escalation ◽

Healthy Subjects ◽

Pharmacokinetics And Pharmacodynamics ◽

Dose Escalation Study ◽

Double Blind ◽

Once Daily ◽

Double Blind Placebo

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Pharmacokinetics and Safety Profile of Bleselumab (ASKP1240) in Patients With Moderate-To-Severe Plaque Psoriasis: Results from a Phase 2A, Randomized, Double-Blind, Placebo-Controlled, Sequential, Multiple-Dose Escalation Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2017.05.208 ◽

2017 ◽

Vol 39 (8) ◽

pp. e68 ◽

Cited By ~ 1

Author(s):

M.S.A. Kumar ◽

R. Tainaka ◽

T. Zhu ◽

X. Wang ◽

J. Montgomery ◽

...

Keyword(s):

Dose Escalation ◽

Plaque Psoriasis ◽

Safety Profile ◽

Multiple Dose ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Severe Plaque Psoriasis

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Faculty Opinions recommendation of A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13409136.14780164 ◽

2011 ◽

Author(s):

John Laffey ◽

Mairead Hayes

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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Relationship Between Absolute Neutrophil Count Profiles and Pharmacokinetics of DA-3031, a Pegylated Granulocyte Colony-Stimulating Factor (Pegylated-G-CSF): A Dose Block-Randomized, Double-Blind, Dose-Escalation Study in Healthy Subjects

Clinical Drug Investigation ◽

10.1007/s40261-013-0130-9 ◽

2013 ◽

Vol 33 (11) ◽

pp. 817-824 ◽

Cited By ~ 5

Author(s):

Li Young Ahn ◽

Kwang-Hee Shin ◽

Kyoung Soo Lim ◽

Tae-Eun Kim ◽

Hyewon Jeon ◽

...

Keyword(s):

Absolute Neutrophil Count ◽

Neutrophil Count ◽

Dose Escalation ◽

Healthy Subjects ◽

Granulocyte Colony Stimulating Factor ◽

Colony Stimulating Factor ◽

Dose Escalation Study ◽

Double Blind ◽

Stimulating Factor

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Pharmacokinetics, Safety, and Tolerability of Intravenous Felbinac Trometamol in Healthy Chinese Volunteers: A First-in-Human Single- and Multiple-Dose Escalation Phase I Study with a Randomized, Double-Blind, Placebo-Controlled Design

CNS Drugs ◽

10.1007/s40263-020-00739-z ◽

2020 ◽

Vol 34 (8) ◽

pp. 867-877

Author(s):

Min Wu ◽

Cuiyun Li ◽

Hong Zhang ◽

Jixuan Sun ◽

Xiaoxue Zhu ◽

...

Keyword(s):

Phase I ◽

Dose Escalation ◽

Phase I Study ◽

Multiple Dose ◽

Double Blind ◽

Double Blind Placebo ◽

Healthy Chinese

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A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction

Yearbook of Cardiology ◽

10.1016/s0145-4145(10)79814-2 ◽

2010 ◽

Vol 2010 ◽

pp. 389-391 ◽

Cited By ~ 3

Author(s):

B.J. Gersh

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Stem Cells ◽

Mesenchymal Stem Cells ◽

Dose Escalation ◽

Human Mesenchymal Stem Cells ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo ◽

Adult Human

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First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica

PLoS ONE ◽

10.1371/journal.pone.0125034 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125034 ◽

Cited By ~ 16

Author(s):

Paul E. Rolan ◽

Gilmore O’Neill ◽

Eve Versage ◽

Jitesh Rana ◽

Yongqiang Tang ◽

...

Keyword(s):

Family Member ◽

Cell Line ◽

Glial Cell ◽

Dose Escalation ◽

Neurotrophic Factor ◽

Dose Escalation Study ◽

Double Blind ◽

Double Blind Placebo

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