Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers

2020 ◽  
Author(s):  
Kun Hu ◽  
Qian Xiang ◽  
Zhe Wang ◽  
Xiaoyan Sheng ◽  
Li'e Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cytochrome P450 ◽  
Genetic Polymorphisms ◽  
Vitamin D Receptor ◽  
Cytochrome P450 3A ◽  
P450 Oxidoreductase ◽  
Cytochrome P450 Oxidoreductase ◽  
Healthy Chinese

Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catalyzed drug metabolism

2008 ◽  
Vol 18 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Steven N. Hart ◽  
Shuang Wang ◽  
Kaori Nakamoto ◽  
Christopher Wesselman ◽  
Ye Li ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Genetic Polymorphisms ◽  
P450 Oxidoreductase ◽  
Cytochrome P450 Oxidoreductase

Genetic Polymorphisms and Haplotypes of POR, Encoding Cytochrome P450 Oxidoreductase, in a Japanese Population

2011 ◽  
Vol 26 (1) ◽  
pp. 107-116 ◽  
Author(s):  
Yoshiro Saito ◽  
Noboru Yamamoto ◽  
Noriko Katori ◽  
Keiko Maekawa ◽  
Hiromi Fukushima-Uesaka ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphisms ◽  
Japanese Population ◽  
P450 Oxidoreductase ◽  
Cytochrome P450 Oxidoreductase

scholarly journals An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Goutam Mukherjee ◽  
Prajwal P. Nandekar ◽  
Rebecca C. Wade
Keyword(s):  
Electron Transfer ◽  
Cytochrome P450 ◽  
Drug Targets ◽  
Catalytic Domain ◽  
Cytochrome P450 1A1 ◽  
P450 Oxidoreductase ◽  
Distal Side ◽  
Cytochrome P450 Oxidoreductase ◽  
Membrane Bound ◽  
Transient Interactions

AbstractCytochrome P450 (CYP) heme monooxygenases require two electrons for their catalytic cycle. For mammalian microsomal CYPs, key enzymes for xenobiotic metabolism and steroidogenesis and important drug targets and biocatalysts, the electrons are transferred by NADPH-cytochrome P450 oxidoreductase (CPR). No structure of a mammalian CYP–CPR complex has been solved experimentally, hindering understanding of the determinants of electron transfer (ET), which is often rate-limiting for CYP reactions. Here, we investigated the interactions between membrane-bound CYP 1A1, an antitumor drug target, and CPR by a multiresolution computational approach. We find that upon binding to CPR, the CYP 1A1 catalytic domain becomes less embedded in the membrane and reorients, indicating that CPR may affect ligand passage to the CYP active site. Despite the constraints imposed by membrane binding, we identify several arrangements of CPR around CYP 1A1 that are compatible with ET. In the complexes, the interactions of the CPR FMN domain with the proximal side of CYP 1A1 are supplemented by more transient interactions of the CPR NADP domain with the distal side of CYP 1A1. Computed ET rates and pathways agree well with available experimental data and suggest why the CYP–CPR ET rates are low compared to those of soluble bacterial CYPs.

Vitamin D receptor rs2228570 and rs1544410 genetic polymorphisms frequency in Iraqi thalassemia patients compared to other ethnic populations

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101131
Author(s):  
Ali Hafedh Abbas ◽  
Dunya Fareed Salloom ◽  
Khawla Ibrahim Misha'al ◽  
Estabraq Abdulhadi Taqi
Keyword(s):  
Vitamin D ◽  
Genetic Polymorphisms ◽  
Vitamin D Receptor ◽  
Ethnic Populations
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