Impact of Tesamorelin, a Growth Hormone-Releasing Factor (GRF) Analogue, on the Pharmacokinetics of Simvastatin and Ritonavir in Healthy Volunteers

2013 ◽  
Vol 2 (3) ◽  
pp. 237-245 ◽  
Author(s):  
Shirley Teng ◽  
Diane Potvin ◽  
Jean-Claude Mamputu ◽  
Geneviève Vincent ◽  
Monika Zoltowska ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Healthy Volunteers ◽  
Growth Hormone Releasing Factor

Growth hormone releasing factor induces prolactin secretion in acromegalic patients but not in normal subjects

1985 ◽  
Vol 109 (4) ◽  
pp. 467-473 ◽  
Author(s):  
Marco Losa ◽  
Jochen Schopohl ◽  
O. Albrecht Müller ◽  
Klaus von Werder
Keyword(s):  
Growth Hormone ◽  
Healthy Volunteers ◽  
Normal Subjects ◽  
Prolactin Secretion ◽  
Placebo Control ◽  
Growth Hormone Releasing Factor ◽  
Previous Therapy ◽  
Active Acromegaly ◽  
Clear Increase

Abstract. The effect of an iv injection of growth hormone releasing factor (GRF) on Prl secretion in healthy volunteers and patients with active acromegaly was investigated. Thirteen normal subjects received 100 μg GRF 1-44, and 19 acromegalics received 100 μg GRF 1-44. Nine normals and 9 patients were given the diluent only and served as placebo control. In healthy volunteers GRF did not affect Prl secretion significantly when compared to placebo, whereas in acromegalics Prl levels after GRF were higher than after placebo. We have divided acromegalics in Prl-responders to GRF (n = 11) and Prl-non-responders (n = 8) using the criterion of strict parallelism between GH and Prl secretion after GRF. In cases with no GH response to GRF a clear increase of Prl levels with the maximum 15–30 min after GRF was also regarded as a Prl response. Acromegalic Prl-responders and Prl-non-responders did not significantly differ in age, sex, previous therapy, and basal GH and Prl levels. However, Prl-non-responders had a significantly reduced response of both GH and Prl to TRH (GH: 147.3 ± 16.0 vs 590.1 ± 127.8%; mean ± se; Prl: 159.4 ± 32.6 vs 504.9 ± 109.3%). It is concluded that 50 or 100 μg GRF does not affect Prl secretion in normal subjects. In contrast, in acromegaly GRF leads to Prl secretion in more than half of all patients.

Growth hormone releasing factor (GRF) infusion in patients with active acromegaly

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S144-S145
Author(s):  
M. LOSA ◽  
J. SCHOPOHL ◽  
P. G. CHIODINI ◽  
A. LIUZZI ◽  
K. VON WERDER
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Releasing Factor ◽  
Active Acromegaly

Synthetic pancreatic growth hormone-releasing factor (GRF-40) stimulates the secretion of the endocrine pancreas

Diabetes ◽  
1986 ◽  
Vol 35 (1) ◽  
pp. 119-123 ◽  
Author(s):  
K. Hermansen ◽  
A. M. Kappelgaard ◽  
J. Esmann ◽  
H. Orskov
Keyword(s):  
Growth Hormone ◽  
Endocrine Pancreas ◽  
Growth Hormone Releasing Factor ◽  
Pancreatic Growth

Effects on Feeding Behavior of Rats of a Cryptic Peptide from the C-Terminal End of Prepro-Growth Hormone-Releasing Factor*

Endocrinology ◽  
1987 ◽  
Vol 121 (6) ◽  
pp. 1960-1965 ◽  
Author(s):  
K. ARASE ◽  
T. SAKAGUCHI ◽  
M. TAKAHASHI ◽  
G. A. BRAY ◽  
N. LING
Keyword(s):  
Growth Hormone ◽  
Feeding Behavior ◽  
Growth Hormone Releasing Factor ◽  
Cryptic Peptide ◽  
Behavior Of Rats

scholarly journals Studies on peptides. CXXXVII Conventional solution synthesis of porcine hypothalamic growth hormone releasing factor (pGRF).

1986 ◽  
Vol 34 (4) ◽  
pp. 1814-1820 ◽  
Author(s):  
MASANORI SHIMOKURA ◽  
YOSHIAKI KISO ◽  
AKIHIKO NAGATA ◽  
MASABUMI TSUDA ◽  
HITOSHI SEKI ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Solution Synthesis ◽  
Growth Hormone Releasing Factor ◽  
Conventional Solution

Effect of Growth Hormone-Releasing Factor on Plasma Growth Hormone, Prolactin and Somatomedin C in Hypopituitary and Short Normal Children

1985 ◽  
Vol 22 (1-2) ◽  
pp. 32-45 ◽  
Author(s):  
Guy Van Vliet ◽  
Danièle Bosson ◽  
Claude Robyn ◽  
Margareta Craen ◽  
Paul Malvaux ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Normal Children ◽  
Somatomedin C ◽  
Growth Hormone Releasing Factor
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