Rivaroxaban crushed tablet suspension characteristics and relative bioavailability in healthy adults when administered orally or via nasogastric tube

2014 ◽  
Vol 3 (4) ◽  
pp. 321-327 ◽  
Author(s):  
Kenneth T. Moore ◽  
Mark A. Krook ◽  
Seema Vaidyanathan ◽  
Troy C. Sarich ◽  
C. V. Damaraju ◽  
...  
Keyword(s):  
Nasogastric Tube ◽  
Relative Bioavailability ◽  
Healthy Adults ◽  
Crushed Tablet

scholarly journals Relative Bioavailability of Apixaban Solution or Crushed Tablet Formulations Administered by Mouth or Nasogastric Tube in Healthy Subjects

2015 ◽  
Vol 37 (8) ◽  
pp. 1703-1712 ◽  
Author(s):  
Yan Song ◽  
Xiaoli Wang ◽  
Itay Perlstein ◽  
Jessie Wang ◽  
Sherif Badawy ◽  
...  
Keyword(s):  
Nasogastric Tube ◽  
Healthy Subjects ◽  
Relative Bioavailability ◽  
Crushed Tablet ◽  
Tablet Formulations

scholarly journals Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults

2015 ◽  
Vol 37 (7) ◽  
pp. 1555-1563 ◽  
Author(s):  
Peter E. Haroldsen ◽  
Donald G. Musson ◽  
Boyd Hanson ◽  
Adrian Quartel ◽  
Charles A. O’Neill
Keyword(s):  
Food Intake ◽  
Relative Bioavailability ◽  
Healthy Adults

The Relative Bioavailability of Temafloxacin Administered through a Nasogastric Tube With and Without Enteral Feeding

1992 ◽  
Vol 22 (Supplement 1) ◽  
pp. 43-47 ◽  
Author(s):  
T.J. Lubowski ◽  
C.H. Nightingale ◽  
K. Sweeney ◽  
R. Quintiliani
Keyword(s):  
Enteral Feeding ◽  
Nasogastric Tube ◽  
Relative Bioavailability

scholarly journals Relative bioavailability in healthy volunteers of ciprofloxacin administered through a nasogastric tube with and without enteral feeding.

1989 ◽  
Vol 33 (7) ◽  
pp. 1118-1120 ◽  
Author(s):  
J H Yuk ◽  
C H Nightingale ◽  
K R Sweeney ◽  
R Quintiliani ◽  
J T Lettieri ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Enteral Feeding ◽  
Nasogastric Tube ◽  
Relative Bioavailability

scholarly journals Injectable Dexamethasone Sodium Phosphate Administered Orally? A Pharmacokinetic Analysis of a Common Emergency Department Practice

2015 ◽  
Vol 20 (2) ◽  
pp. 105-111
Author(s):  
Alexander Toledo ◽  
Christopher S. Amato ◽  
Nigel Clarke ◽  
Richard E. Reitz ◽  
David Salo
Keyword(s):  
Sodium Phosphate ◽  
Area Under The Curve ◽  
Relative Bioavailability ◽  
Healthy Adults ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Analysis ◽  
Pharmacokinetic Data ◽  
Open Label ◽  
Dexamethasone Sodium Phosphate ◽  
The Mean

BACKGROUND: The injectable formulation of dexamethasone has been administered orally, for the treatment of pediatric asthma and croup. The practice is followed in emergency departments around the country, but pharmacokinetic data supporting this practice are lacking. OBJECTIVES: This study evaluated the relative bioavailability and pharmacokinetics of dexamethasone sodium phosphate for injection (DSPI) administered orally compared to dexamethasone oral concentrate (DOC) in healthy adults. METHODS: This was an open label, crossover study of 11 healthy adults 18 to 45 years of age. All subjects received 8 mg of dexamethasone oral concentrate initially. After a 1-week wash-out period, subjects received 8 mg of DSPI administered orally. Dexamethasone levels were measured by liquid chromatography in tandem mass spectrometry. Cmax and area under the curve (AUC (0-t) and AUC (0-∞)) were calculated and compared between groups using the paired t test. RESULTS: The mean ± SD AUC(0-t) for dexamethasone oral concentrate and DSPI were 5497.23 ± 1649 and 4807.82 ± 1971) ng/dL/hr, respectively; 90% confidence interval (CI) was 78.8%–96.9%. The mean ± SD AUC(0-∞) for dexamethasone oral concentrate and DSPI were 6136.43 ± 2577 and 5591.48 ± 3075 ng/dL/hr, respectively; 90% CI was 79.0% –105.2%. Mean Cmax ± SD for DOC and DSPI were 942.94 ± 151 and 790.92 ± 229 ng/dL, respectively; 90% CI 76.8%–91.7%. The relative bioavailability of DSPI administered orally was 87.4% when using AUC(0-t) and 91.1% when using AUC(0-∞). The calculated absolute bioavailability was 75.9%. CONCLUSIONS: DSPI is not bioequivalent to dexamethasone oral concentrate when administered orally. The existing literature supports the efficacy of DSPI despite this. Dosing adjustments may be considered.

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