Evaluation of the Pharmacokinetics of Felcisetrag (TAK‐954), a 5‐HT 4 Receptor Agonist, in the Presence and Absence of Itraconazole, a Potent CYP3A4 Inhibitor

2022 ◽  
Author(s):  
Chunlin Chen ◽  
Liming Zhang ◽  
Cristina Almansa ◽  
Maria Rosario ◽  
Michael Cwik ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Cyp3a4 Inhibitor ◽  
Presence And Absence

Effects of Noise and Increased Vocal Intensity on Stuttering

1977 ◽  
Vol 20 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Sharon F. Garber ◽  
Richard R. Martin
Keyword(s):  
Normal Level ◽  
Auditory Feedback ◽  
Concomitant Increase ◽  
Vocal Intensity ◽  
Presence And Absence

The present study was designed to assess the effects of increased vocal level on stuttering in the presence and absence of noise, and to assess the effects of noise on stuttering with and without a concomitant increase in vocal level. Accordingly, eight adult stutterers spoke in quiet with normal vocal level, in quiet with increased vocal level, in noise with normal level, and in noise with increased level. All subjects reduced stuttering in noise compared with quiet conditions. However, there was no difference in stuttering when subjects spoke with normal compared with increased vocal level. In the present study, reductions in stuttering under noise could not be explained by increases in vocal level. It appears, instead, that reductions in stuttering were related to a decrease in auditory feedback. The condition which resulted in the largest decrease in auditory feedback, speaking in noise with a normal level, also resulted in the largest decrease in stuttering.

MKC-733, a selective 5-HT3 receptor agonist, stimulates fasting human antral motility

2001 ◽  
Vol 120 (5) ◽  
pp. A460-A461 ◽  
Author(s):  
N COLEMAN ◽  
J WRIGHT ◽  
M PARKER ◽  
R SPILLER
Keyword(s):  
Receptor Agonist ◽  
Antral Motility

1197: AT-Home Efficacy of an Intranasally Administered Melanocortin Receptor Agonist, PT-141, In Men with Erectile Dysfunction (ED)

2004 ◽  
Vol 171 (4S) ◽  
pp. 316-316
Author(s):  
Hunter Wessells ◽  
Harin Padma-Nathan ◽  
Jacob Rajfer ◽  
Robert Feldman ◽  
Raymond Rosen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Receptor Agonist ◽  
Melanocortin Receptor ◽  
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