scholarly journals Native Chemical Ligation of Peptides and Proteins

2019 ◽  
Vol 11 (1) ◽  
pp. e61 ◽  
Author(s):  
Philip A. Cistrone ◽  
Michael J. Bird ◽  
Dillon T. Flood ◽  
Anthony P. Silvestri ◽  
Jordi C. J. Hintzen ◽  
...  
Keyword(s):  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Ligation Of Peptides

Ionic liquid 1-ethyl-3-methylimidazolium acetate: an attractive solvent for native chemical ligation of peptides

2014 ◽  
Vol 55 (27) ◽  
pp. 3658-3662 ◽  
Author(s):  
Toni Kühl ◽  
Ming Chen ◽  
Kathleen Teichmann ◽  
Annegret Stark ◽  
Diana Imhof
Keyword(s):  
Ionic Liquid ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Ligation Of Peptides

scholarly journals A PEGylated Photocleavable Auxiliary Mediates the Sequential Enzymatic Glycosylation and Native Chemical Ligation of Peptides

2015 ◽  
Vol 54 (26) ◽  
pp. 7711-7715 ◽  
Author(s):  
Claudia Bello ◽  
Shuo Wang ◽  
Lu Meng ◽  
Kelley W. Moremen ◽  
Christian F. W. Becker
Keyword(s):  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Enzymatic Glycosylation ◽  
Ligation Of Peptides

Direct Characterization of Native Chemical Ligation of Peptides on Silicon Nanowires

Langmuir ◽  
2012 ◽  
Vol 28 (37) ◽  
pp. 13336-13344 ◽  
Author(s):  
Nabil Dendane ◽  
Oleg Melnyk ◽  
Tao Xu ◽  
Bruno Grandidier ◽  
Rabah Boukherroub ◽  
...  
Keyword(s):  
Silicon Nanowires ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Ligation Of Peptides

scholarly journals Autocatalytic and oscillatory reaction networks that form guanidines and products of their cyclization

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Alexander I. Novichkov ◽  
Anton I. Hanopolskyi ◽  
Xiaoming Miao ◽  
Linda J. W. Shimon ◽  
Yael Diskin-Posner ◽  
...  
Keyword(s):  
Chemical Cues ◽  
Native Chemical Ligation ◽  
Reaction Networks ◽  
Oscillatory Reaction ◽  
Experimental Conditions ◽  
Chemical Ligation ◽  
Chemical Systems ◽  
Life On Earth ◽  
Emergence Of Life ◽  
Equilibrium Chemical

AbstractAutocatalytic and oscillatory networks of organic reactions are important for designing life-inspired materials and for better understanding the emergence of life on Earth; however, the diversity of the chemistries of these reactions is limited. In this work, we present the thiol-assisted formation of guanidines, which has a mechanism analogous to that of native chemical ligation. Using this reaction, we designed autocatalytic and oscillatory reaction networks that form substituted guanidines from thiouronium salts. The thiouronium salt-based oscillator show good stability of oscillations within a broad range of experimental conditions. By using nitrile-containing starting materials, we constructed an oscillator where the concentration of a bicyclic derivative of dihydropyrimidine oscillates. Moreover, the mixed thioester and thiouronium salt-based oscillator show unique responsiveness to chemical cues. The reactions developed in this work expand our toolbox for designing out-of-equilibrium chemical systems and link autocatalytic and oscillatory chemistry to the synthesis of guanidinium derivatives and the products of their transformations including analogs of nucleobases.

scholarly journals Oxo-ester Mediated Native Chemical Ligation: Concept and Applications

2008 ◽  
Vol 130 (47) ◽  
pp. 15814-15816 ◽  
Author(s):  
Qian Wan ◽  
Jin Chen ◽  
Yu Yuan ◽  
Samuel J. Danishefsky
Keyword(s):  
Native Chemical Ligation ◽  
Chemical Ligation
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