scholarly journals The RNA ‐binding protein La/ SSB associates with radiation‐induced DNA double‐strand breaks in lung cancer cell lines

2021 ◽  
Author(s):  
Alexander H. Staudacher ◽  
Yanrui Li ◽  
Vasilios Liapis ◽  
Michael P. Brown
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Lung Cancer Cell ◽  
Strand Breaks ◽  
Radiation Induced

scholarly journals The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1

2017 ◽  
Vol 45 (11) ◽  
pp. 6530-6545 ◽  
Author(s):  
Chiara Vittoria Colombo ◽  
Camilla Trovesi ◽  
Luca Menin ◽  
Maria Pia Longhese ◽  
Michela Clerici
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks

scholarly journals PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks

2012 ◽  
Vol 40 (20) ◽  
pp. 10287-10301 ◽  
Author(s):  
Jana Krietsch ◽  
Marie-Christine Caron ◽  
Jean-Philippe Gagné ◽  
Chantal Ethier ◽  
Julien Vignard ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Parp Activation ◽  
Strand Breaks ◽  
Damage Response

scholarly journals DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29012 ◽  
Author(s):  
Yukihiro Furusawa ◽  
Yoshisada Fujiwara ◽  
Paul Campbell ◽  
Qing-Li Zhao ◽  
Ryohei Ogawa ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Mechanical Effects

Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance

2021 ◽  
Author(s):  
Guangxian Mao ◽  
Zhimin Mu ◽  
Da Wu
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cancer Progression ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
A549 Cells ◽  
Akt Pathway ◽  
Lung Cancer Cell

Abstract Long non-coding RNA (lncRNA) FOXD3-AS1 expression is upregulated in lung cancer; however, its effect and mechanism on 5-fluorouracil (5-FU) resistance remain unclear. In this study, we determined the effects of FOXD3-AS1-enriched exosomes derived from lung cancer cells on the proliferation, invasion, and 5-FU resistance of lung cancer cells. Online bioinformatics database analysis showed that FOXD3-AS1 was upregulated in lung cancer progression. Real-time quantitative PCR results confirmed that FOXD3-AS1 expression was upregulated in lung cancer tissues and cell lines, and FOXD3-AS1 was greatly enriched in lung cancer cell-derived exosomes. ELAV-like RNA-binding protein 1 (ELAVL1) was identified as an RNA-binding protein of FOXD3-AS1. The lung cancer cell-derived exosomes promoted A549 cell proliferation and invasion and inhibited apoptosis caused by 5-FU, and transfection of si-FOXD3-AS1 or si-ELAVL1 in exosome-incubated A549 cells reversed these effects. Moreover, exosome-incubated A549 cells were co-transfected with si-FOXD3-AS1 and pcDNA-ELAVL1, showing the same cell proliferation, invasion, and 5-FU resistance as those of A549 cells treated with lung cancer cell-derived exosomes alone. Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes. In conclusion, our study revealed that lung cancer cell-derived exosomal FOXD3-AS1 upregulated ELAVL1 expression and activated the PI3K/Akt pathway to promote lung cancer progression. Our findings provide a new strategy for lung cancer treatment.

scholarly journals Expression profiling of lung cancer cell lines

10.1038/87074 ◽  
2001 ◽  
Vol 27 (S4) ◽  
pp. 53-53
Author(s):  
Priya Dayananth ◽  
Terri McClanahan ◽  
Ferdous Gheyas ◽  
Marco Hernandez ◽  
Wei Ding ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Expression Profiling ◽  
Cancer Cell Lines ◽  
Lung Cancer Cell
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