scholarly journals L‐asparaginase doses number as a prognostic factor in childhood acute lymphoblastic leukemia: A survival analysis study

2021 ◽  
Author(s):  
Amanda Cabral Santos ◽  
Julia Maria Bispo Santos ◽  
Elisangela Lima ◽  
Marcelo Gerardin Poirot Land
Keyword(s):  
Survival Analysis ◽  
Acute Lymphoblastic Leukemia ◽  
Prognostic Factor ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Analysis Study

scholarly journals Renal size as a prognostic factor in childhood acute lymphoblastic leukemia

Cancer ◽  
1981 ◽  
Vol 48 (1) ◽  
pp. 207-209 ◽  
Author(s):  
I. M. Hann ◽  
P. D. Lees ◽  
M. K. Palmer ◽  
S. Gupta ◽  
P. H. Morris-Jones
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prognostic Factor ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Renal Size

Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia

Blood ◽  
2006 ◽  
Vol 109 (2) ◽  
pp. 471-477 ◽  
Author(s):  
Jaewon Choi ◽  
Yu Kyeong Hwang ◽  
Ki Woong Sung ◽  
Soo Hyun Lee ◽  
Keon Hee Yoo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prognostic Factor ◽  
Prognostic Marker ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Relapse Free Survival ◽  
Treatment Protocols ◽  
Childhood All ◽  
Free Survival ◽  
Favorable Prognostic Factor

Abstract Livin, a member of the inhibitor of apoptosis proteins, has been considered to be a poor prognostic marker in malignancies. However, little is known about the clinical relevance of Livin expression in childhood acute lymphoblastic leukemia (ALL). In this study, the expression of Livin was analyzed in 222 patients with childhood ALL using quantitative reverse transcriptase–polymerase chain reaction (RT-PCR) to investigate a possible association with the clinical features at diagnosis and treatment outcomes. Both Livin expression rates and expression levels were higher in patients with favorable prognostic factors. The expression rate was also higher in patients with a favorable day 7 bone marrow response to induction chemotherapy (P < .001). The Livin expression was related to the absence of relapse (P < .001). Similarly, the relapse-free survival rate (± 95% CI) was higher in patients with Livin expression than in patients without Livin expression (97.9% ± 4.0% versus 64.9% ± 11.8%, P < .001). Multivariate analysis for relapse-free survival demonstrated that Livin expression was an independent favorable prognostic factor in childhood ALL (P = .049). This study suggests that Livin expression is a novel prognostic marker in childhood ALL and thus needs to be incorporated into the patient stratification and treatment protocols.

p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia

Blood ◽  
2002 ◽  
Vol 99 (7) ◽  
pp. 2620-2623 ◽  
Author(s):  
Jean Hughes Dalle ◽  
Martine Fournier ◽  
Brigitte Nelken ◽  
Françoise Mazingue ◽  
Jean-Luc Laı̈ ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prognostic Factor ◽  
Lymphoblastic Leukemia ◽  
Independent Prognostic Factor ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Significant Prognostic Factor ◽  
Event Free Survival ◽  
Childhood All ◽  
Free Survival ◽  
First Relapse

We investigated the prognostic value of p16INK4aimmunocytochemistry (ICC) analysis in 126 cases of newly diagnosed childhood acute lymphoblastic leukemia (ALL). The incidence of negative p16INK4a ICC was 38.1% and was more frequent in T-lineage ALL. Overall survival (OS) and event-free survival (EFS) were significantly higher in patients with positive p16INK4a ICC than in patients with negative ICC (6 years OS, 90% versus 63%,P = .0014; 6 years EFS, 77.8% versus 55%,P = .0033). The p16INK4a ICC remained a significant prognostic factor within the subgroup of B-precursor ALL. Multivariate analysis showed that negative p16INK4a ICC was an independent prognostic factor for OS (relative risk [RR], 3.38;P = .02) and EFS (RR, 2.49; P = .018). Sequential study showed that p16INK4a expression remained stable during first relapse in most patients. These findings indicate that p16INK4a ICC is an independent factor of outcome in childhood ALL.

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