scholarly journals SCR7 , a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining

2021 ◽  
Author(s):  
Meghana Manjunath ◽  
Bibha Choudhary ◽  
Sathees C. Raghavan
Keyword(s):  
Therapeutic Agent ◽  
End Joining ◽  
Nonhomologous Dna End Joining

scholarly journals Nonhomologous DNA end joining of synthetic hairpin substrates inXenopus laevisegg extracts

1994 ◽  
Vol 22 (9) ◽  
pp. 1643-1650 ◽  
Author(s):  
Nicole Beyert ◽  
Susanne Reichenberger ◽  
Michael Peters ◽  
Markus Hartung ◽  
Bernd Göttlich ◽  
...  
Keyword(s):  
End Joining ◽  
Nonhomologous Dna End Joining

Dramatic Changes in the Ratio of Homologous Recombination to Nonhomologous DNA-End Joining in Oocytes and Early Embryos ofXenopus laevis

1996 ◽  
Vol 377 (4) ◽  
pp. 239-250 ◽  
Author(s):  
Michael Hagmann ◽  
Katrin Adlkofer ◽  
Petra Pfeiffer ◽  
Rémy Bruggmann ◽  
Oleg Georgiev ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
End Joining ◽  
Early Embryos ◽  
Nonhomologous Dna End Joining

scholarly journals Aberrant V(D)J Recombination in Ataxia Telangiectasia Mutated-Deficient Lymphocytes Is Dependent on Nonhomologous DNA End Joining

2008 ◽  
Vol 181 (4) ◽  
pp. 2620-2625 ◽  
Author(s):  
Andrea L. Bredemeyer ◽  
Ching-Yu Huang ◽  
Laura M. Walker ◽  
Craig H. Bassing ◽  
Barry P. Sleckman
Keyword(s):  
Ataxia Telangiectasia ◽  
Ataxia Telangiectasia Mutated ◽  
End Joining ◽  
Nonhomologous Dna End Joining

scholarly journals Nonhomologous DNA end-joining for repair of DNA double-strand breaks

2017 ◽  
Vol 293 (27) ◽  
pp. 10512-10523 ◽  
Author(s):  
Nicholas R. Pannunzio ◽  
Go Watanabe ◽  
Michael R. Lieber
Keyword(s):  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Strand Breaks ◽  
Nonhomologous Dna End Joining

Pluronic copolymer encapsulated SCR7 as a potential anticancer agent

2015 ◽  
Vol 177 ◽  
pp. 155-161 ◽  
Author(s):  
Franklin John ◽  
Jinu George ◽  
Mrinal Srivastava ◽  
P. A. Hassan ◽  
V. K. Aswal ◽  
...  
Keyword(s):  
Therapeutic Agent ◽  
Analytical Techniques ◽  
Double Strand Breaks ◽  
Nonhomologous End Joining ◽  
Physical Interaction ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Strand Breaks ◽  
Anticancer Properties

Nonhomologous end joining (NHEJ) of DNA double strand breaks (DSBs) inside cells can be selectively inhibited by 5,6-bis-(benzylideneamino)-2-mercaptopyrimidin-4-ol (SCR7) which possesses anticancer properties. The hydrophobicity of SCR7 decreases its bioavailability which is a major setback in the utilization of this compound as a therapeutic agent. In order to circumvent the drawback of SCR7, we prepared a polymer encapsulated form of SCR7. The physical interaction of SCR7 and Pluronic® copolymer is evident from different analytical techniques. The in vitro cytotoxicity of the drug formulations is established using the MTT assay.

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