β‐Cyclodextrin‐Decorated Carbon Dots Serve as Nanocarriers for Targeted Drug Delivery and Controlled Release

ChemNanoMat ◽  
2019 ◽  
Vol 5 (4) ◽  
pp. 479-487 ◽  
Author(s):  
Ting Yang ◽  
Jing‐Li Huang ◽  
Yi‐Ting Wang ◽  
An‐Qi Zheng ◽  
Yang Shu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Carbon Dots ◽  
Targeted Drug

Rational design of hollow mesoporous titania nanoparticles loaded with curcumin for UV-controlled release and targeted drug delivery

2021 ◽  
Vol 32 (20) ◽  
pp. 205604
Author(s):  
Zhuoxian Mai ◽  
Jiali Chen ◽  
Qingyun Cao ◽  
Yang Hu ◽  
Xianming Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Rational Design ◽  
Titania Nanoparticles ◽  
Mesoporous Titania ◽  
Targeted Drug

scholarly journals Oral Controlled Delivery of Natural Compounds Using Food-Grade Polymer Microparticles

2020 ◽  
Vol 01 ◽  
Author(s):  
Claudia Curcio ◽  
Angela Bonaccorso ◽  
Teresa Musumeci ◽  
Rosario Pignatello
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Polymeric Materials ◽  
Herbal Remedies ◽  
Ph Change ◽  
Coating Materials ◽  
Food Grade ◽  
Targeted Drug

Background:: targeted drug delivery to colon is a strategical approach for the local cure of inflammation bowel diseases (IBD) and other syndromes like colon cancer. Research is actively focusing on possible alternative and safer therapies to conventional drugs, based on herbal remedies and other natural products. In particular, colon-targeted drug delivery systems (CDDS) offer the opportunity to protect the active compound along the way to the colon. Drug release and absorption, and even degradation should not occur in the stomach and small bowel, but a selective release should star once the system moves to the colonic area. Objective:: this work aims at evaluating the gastro-resistant properties of new food-grade methacrylic resins (Eudraguard®), used not as coating materials, but after the formation of microparticles, to achieve a delayed and targeted release of a model drug, resveratrol (RVT), to the ileo-colonic area. Methods:: microparticles were produced by an emulsion-solvent evaporation technique (ESE) and characterized by solid-state analytical methods. RVT release profiles were assessed in vitro using a pH-change procedure, able to simulate the transit of the carrier along the gastro-intestinal tract. Results:: Eudraguard® Biotic can form microparticles with a very high encapsulation efficiency for RVT; the polymeric matrix is able to limit the diffusion of the drug at gastric and gut pH conditions, while a higher release was achieved at pH 7.4. Conversely, using the Eudraguard® Control resin, alone or blended with the former polymer, did not allow to achieve a controlled release of RVT at the various pH values. Conclusion:: food-grade Eudraguard® matrices can be proposed, and would deserve further investigations, as polymeric materials for the preparation of micrometric matrices or pellets for the oral controlled release of natural active ingredients to the ileo-colonic area.

scholarly journals Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 581 ◽  
Author(s):  
Lixin Wang ◽  
Yunmei Song ◽  
Ankit Parikh ◽  
Paul Joyce ◽  
Rosa Chung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Flow Cytometric Analysis ◽  
Laser Scanning Microscopy ◽  
Covalent Attachment ◽  
Confocal Laser ◽  
Anti Cancer ◽  
Targeted Drug

Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use as a targeted drug delivery vehicle. MPI is readily endocytosed by monocytes, macrophages, and dendritic cells and in this study, we sought to utilize this property to develop a system to target anti-cancer drugs to lymphoid organs. We investigated, therefore, whether MPI could be used as a vehicle to deliver doxorubicin selectively, thereby reducing the toxicity of this antibiotic anthracycline drug. Doxorubicin was covalently attached to the surface of MPI using an acid–labile linkage to enable pH-controlled release. The MPI-doxorubicin conjugate was characterized using FTIR and SEM, confirming covalent attachment and indicating doxorubicin coupling had no obvious impact on the physical nanostructure, integrity, and cellular uptake of the MPI particles. To simulate the stability of the MPI-doxorubicin in vivo, it was stored in artificial lysosomal fluid (ALF, pH 4.5). Although the MPI-doxorubicin particles were still visible after 165 days in ALF, 53% of glycosidic bonds in the inulin particles were hydrolyzed within 12 days in ALF, reflected by the release of free glucose into solution. By contrast, the fructosidic bonds were much more stable. Drug release studies of the MPI-doxorubicin in vitro, demonstrated a successful pH-dependent controlled release effect. Confocal laser scanning microscopy studies and flow cytometric analysis confirmed that when incubated with live cells, MPI-doxorubicin was efficiently internalized by immune cells. An assay of cell metabolic activity demonstrated that the MPI carrier alone had no toxic effects on RAW 264.7 murine monocyte/macrophage-like cells, but exhibited anti-cancer effects against HCT116 human colon cancer cells. MPI-doxorubicin had a greater anti-cancer cell effect than free doxorubicin, particularly when at lower concentrations, suggesting a drug-sparing effect. This study establishes that MPI can be successfully modified with doxorubicin for chemotherapeutic drug delivery.

Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery

2015 ◽  
Vol 3 (10) ◽  
pp. 1386-1394 ◽  
Author(s):  
Yanan Luo ◽  
Xuenv Wang ◽  
Dan Du ◽  
Yuehe Lin
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Controlled Release ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Protein Cage ◽  
Targeted Drug

In this paper, we proposed a naturally derived protein cage based pH-responsive delivery system for intracellular prodrug controlled release.

scholarly journals Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates

2016 ◽  
Vol 52 (68) ◽  
pp. 10357-10360 ◽  
Author(s):  
Pamela T. Wong ◽  
Shengzhuang Tang ◽  
Jhindan Mukherjee ◽  
Kenny Tang ◽  
Kristina Gam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Release Mechanism ◽  
Targeted Drug ◽  
Active Release ◽  
Dendrimer Conjugates

We report a light-controlled release mechanism for photocaged ciprofloxacin nanoconjugate. Validation of this bacteria-targeted strategy adds a novel modality to light-based therapies for wound treatments.

Carbon Dots as Nanotherapeutics for Biomedical Application

2020 ◽  
Vol 26 (19) ◽  
pp. 2207-2221 ◽  
Author(s):  
Eemaan N. Cohen ◽  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Lisa C. du Toit ◽  
Viness Pillay
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Carbon Dots ◽  
Water Solubility ◽  
Biomedical Application ◽  
Drug Efficacy ◽  
Cost Effective ◽  
Carbon Nanodots ◽  
Targeted Drug

Carbon nanodots are zero-dimensional spherical allotropes of carbon and are less than 10nm in size (ranging from 2-8nm). Based on their biocompatibility, remarkable water solubility, eco- friendliness, conductivity, desirable optical properties and low toxicity, carbon dots have revolutionized the biomedical field. In addition, they have intrinsic photo-luminesce to facilitate bio-imaging, bio-sensing and theranostics. Carbon dots are also ideal for targeted drug delivery. Through functionalization of their surfaces for attachment of receptor-specific ligands, they ultimately result in improved drug efficacy and a decrease in side-effects. This feature may be ideal for effective chemo-, gene- and antibiotic-therapy. Carbon dots also comply with green chemistry principles with regard to their safe, rapid and eco-friendly synthesis. Carbon dots thus, have significantly enhanced drug delivery and exhibit much promise for future biomedical applications. The purpose of this review is to elucidate the various applications of carbon dots in biomedical fields. In doing so, this review highlights the synthesis, surface functionalization and applicability of biodegradable polymers for the synthesis of carbon dots. It further highlights a myriad of biodegradable, biocompatible and cost-effective polymers that can be utilized for the fabrication of carbon dots. The limitations of these polymers are illustrated as well. Additionally, this review discusses the application of carbon dots in theranostics, chemo-sensing and targeted drug delivery systems. This review also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life.

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